1978
DOI: 10.1152/ajpendo.1978.234.6.e542
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Uptake of labeled palmitate by the intact liver: role of intracellular binding sites.

Abstract: The multiple-indicator dilution technique was utilized to examine the hepatic uptake of albumin-bound labeled palmitate from the portal vein blood of the pentobarbital-anesthetized dog, in a fasted state and after infusion of a variety of compounds that were expected to bind to Z protein, the cellular cytosolic protein binding free fatty acids, and their acyl-CoA derivatives. Analysis of the data indicates that after infusion of alpha-bromopalmitate, 16-bromo-9-hexadecenoate, and sulfobromophthalein sodium (wh… Show more

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Cited by 32 publications
(28 citation statements)
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“…4, A-C) emphasizes the role of palmitate diffusion bound to L-FABP as a determinant of its extraction. Uptake and intracellular trafficking of fatty acids has been studied in hepatocyte suspensions (1,8) and perfused rat liver (17,18,26,39). In those studies, it is generally acknowledged that the transmembrane flux of long-chain fatty acids occurs by diffusion and by a transmembrane transporter (i.e., FABP).…”
Section: Discussionmentioning
confidence: 99%
“…4, A-C) emphasizes the role of palmitate diffusion bound to L-FABP as a determinant of its extraction. Uptake and intracellular trafficking of fatty acids has been studied in hepatocyte suspensions (1,8) and perfused rat liver (17,18,26,39). In those studies, it is generally acknowledged that the transmembrane flux of long-chain fatty acids occurs by diffusion and by a transmembrane transporter (i.e., FABP).…”
Section: Discussionmentioning
confidence: 99%
“…Goresky and coworkers (38) have determined the rate constants for palmitate transport in the intact dog. Their results suggest that metabolism should be relatively more important than influx in determining the rate of hepatic palmitate removal at steadystate in vivo.…”
Section: Discussionmentioning
confidence: 99%
“…If, how-efflux rates following a brief period of uptake. 37,38 ever, P m Ó· P c , then a large concentration gradient will form Membrane carriers for bile acids have been defined in both at steady-state in the presence of an effective biliary secretion the plasma and canalicular poles of the liver cell. 39 They are mechanism † (Fig.…”
Section: Permeability Of the Cytoplasmmentioning
confidence: 99%
“…78 Although convection and vesicular tate, which competes with fatty acids for binding to fatty acid transport may contribute significantly to cytoplasmic trans-binding protein, greatly reduced uptake rates by displacing port of some amphipathic molecules, 79-82 most cytoplasmic fatty acids from the FABP onto intracellular membranes 100 transport is believed to occur by diffusion of the amphipath and promoting efflux from the cell. 37 Indeed, the steady upwhile it is bound to cytoplasmic binding proteins. 78,83,84 take rate of fatty acids by liver cells correlates closely with A role for soluble binding proteins in transport has long the soluble (protein-bound) fraction in the cytoplasm (Fig.…”
Section: Binding Proteinsmentioning
confidence: 99%