Uptake of osteotropic radionuclides in the breast

Burnett, K.; Lyons, Kenneth P.; Brown, W. Theron

doi:10.1016/s0001-2998(84)80056-2

Cited by 16 publications

(4 citation statements)

References 5 publications

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“…The actual mechanism of uptake in the malignant lesion is not known. The postulated causes of 99m Tc-MDP uptake in extraosseous neoplasms are numerous and include tumor vascularity, inflammation, local pH factors, altered calcium metabolism, hormonal influences and cell wall damage [4,5]. Our case shows that TCC of the bladder was incidentally diagnosed due to MDP uptake in multiple bladder polyps detected on a bone scan done for low backache in an 80-year-old man.…”

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confidence: 85%

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Incidental Diagnosis of Carcinoma of the Bladder Due to Uptake of 99mTc-MDP

Damle

Mishra

Subbarao

et al. 2012

Nucl Med Mol Imaging

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An 80-year-old male patient presented to the orthopaedist for evaluation of low backache. A bone scan was performed using 740 MBq (20 mCi) 99m Tc-MDP. Wholebody planar images were acquired 3 h after injection (Fig. 1). The scan revealed normal physiological tracer uptake in skeletal system but irregular and heterogenous accumulation of tracer in the bladder (Fig. 2). To evaluate this abnormal accumulation further, the patient was given a dose of 40 mg furosemide and asked to drink plenty of water. He was instructed to void three to four times within 2-3 h. After 3 h, the urine became less radioactive. An SPECT-CT image of pelvis was acquired, and the images revealed intense multifocal uptake in multiple bladder polyps (Figs. 3, 4). Urine cytology was done, which subsequently revealed malignant cells. Further evaluation with cystoscopic biopsy confirmed transitional cell carcinoma (TCC) of the bladder. Intraoperatively multiple broad based polyps were seen in the dome of the bladder. Transurethral resection of the

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confidence: 85%

“…Soft tissue uptake of 99m Tc-MDP is described in various benign and malignant conditions [1][2][3][4]. It is known to accumulate in adenocarcinoma of lung, primary breast cancer, and colonic carcinoma among others.…”

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confidence: 99%

Incidental Diagnosis of Carcinoma of the Bladder Due to Uptake of 99mTc-MDP

Damle

Mishra

Subbarao

et al. 2012

Nucl Med Mol Imaging

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Section: Planar and Spect Scintigraphymentioning

confidence: 99%

“…Benign processes such as fibroadenomas, fibrocystic disease, lactational change, gynecomastia, breast implants, hematomas, and fat necrosis have also been reported to demonstrate increased uptake on bone scan (9). These are rare causes of MDP accumulation and may be related to local metabolic conditions, inflammation, collagen deposition, and/or increased blood flow (9). One study found that following injection of 99m Tc-MDP, background breast parenchymal uptake remained constant; however, uptake in breast cancers peaked at 10-20 minutes following injection, with a mean tumor-to-background ratio of 3.8 (10).…”

Section: Planar and Spect Scintigraphymentioning

confidence: 99%

Management of Incidental Breast Lesions Detected at Nuclear Medicine Examinations

Rahman

Neal

Nees

et al. 2020

Radiology: Imaging Cancer

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N uclear medicine studies such as bone scan, lymphoscintigraphy, and fluorine 18 ( 18 F) fluorodeoxyglucose (FDG) PET/CT may be performed in patients with breast cancer for staging and treatment planning. Focal or diffuse radiotracer uptake can also be incidentally found within the breast in patients without breast cancer. These findings may be clinically relevant and could correlate with mammogram or breast US to help confirm a suspected diagnosis, which may save the patient additional workup and anxiety. Certain lesions may demonstrate avid uptake of one radiotracer but fail to have any uptake of another. Familiarity with the expected level of radiotracer uptake of specific breast lesions may also aid in making the correct diagnosis. There are PET radiotracers including gallium 68 ( 68 Ga) tetraazacyclododecane tetraacetic acid octreotate (DOTATATE), 18 F-fluciclovine, and 68 Ga-prostate-specific membrane antigen (PSMA) that may also demonstrate incidental breast uptake. Reviewing pathologic correlation of these incidental lesions can be helpful in future imaging interpretation.The goals of this review are to demonstrate the spectrum of breast lesions that can be detected on various molecular imaging studies, present relevant features on correlative anatomic imaging, and help the reader obtain additional imaging when warranted. This institutional review boardapproved, Health Insurance Portability and Accountability Act-compliant pictorial essay will provide an overview of various planar, SPECT, and PET nuclear medicine studies and the breast lesions that can be detected at each.

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Soft Tissue Uptake of Bone Agents

Gray¹

1987

Bone Scanning in Clinical Practice

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Uptake of osteotropic radionuclides in the breast

Cited by 16 publications

References 5 publications

Incidental Diagnosis of Carcinoma of the Bladder Due to Uptake of 99mTc-MDP

Incidental Diagnosis of Carcinoma of the Bladder Due to Uptake of 99mTc-MDP

Management of Incidental Breast Lesions Detected at Nuclear Medicine Examinations

Soft Tissue Uptake of Bone Agents

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