Uptake of peroxidase from the third ventricle by ependymal cells of the median eminence

Kobayashi, Hideshi; Wada, Mitsuru; Uemura, Hirotsugu; Ueck, M.

doi:10.1007/bf00306870

Cited by 90 publications

(22 citation statements)

References 5 publications

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“…Nevertheless, induction of MT was found in ependymal cells only by direct injection of zinc ions into the third ventricle of the brain of Mongolian gerbils, supporting the hypothesis of direct uptake of zinc into the cells from the cerebrospinal fluid (Yoshimine et al, unpublished data). This observation is consistent with the findings on the uptake of peroxidase (Kobayashi et al, 1972) and luteinizing hormone-releasing hormone (Uemura et al, 1975) from the ventricles. In the pia mater, the pial cells, resting macrophages (Nabeshima et al, 1975), may defend against the undesirable foreign substances present in the cerebrospinal fluid, since the cells have the capacity to store foreign substances, such as dye, introduced by a direct injection into the subarachnoid space (Bloom and Fawcett, 1986).…”

Section: Discussionsupporting

confidence: 93%

Localization of metallothionein in the brain of rat and mouse.

Nishimura¹,

Nishimura²,

Abdel-Ghaffar³

et al. 1992

J Histochem Cytochem.

112

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Metallothionein (MT) is a low molecular mass protein inducible by heavy metals such as cadmium (Cd), zinc, and copper, and having high affiity for these metals. In the present study, we investigated the immunohistological localization of MT in the brains of rats and mice. In adult rat brain, almost no MT immunostaining was observed, whereas in adult mouse brain strong MT immunostaining was found in the ependymal cells, some glial cells, arachnoid, and pia mater. No immunostahhg was detected in neurons and endothelial cells. In younger rats (1-3 weeks old), strong MT immunostaining was observed in ependymal cells, choroid plexus epithelium, arachnoid, and pia mater. The overall MT concentration in adult mouse brain appeared higher than that of the brains of young and adult rats. When adult rats

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Section: Discussionsupporting

confidence: 93%

Localization of metallothionein in the brain of rat and mouse.

Nishimura¹,

Nishimura²,

Abdel-Ghaffar³

et al. 1992

J Histochem Cytochem.

112

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“…Extensive reviews on this sub ject are also available [Kirsche, 1967;Knowles, 1974;Sterba, 1974;Rodriguez, 1976;Leonhardt, 1977]. Tanycytes of the infundibular recess are known to have secre tory and transport functions [Ldfgren, 1959[Ldfgren, , 1960Vigh et al" 1961Vigh et al" , 1962, The mor phological contact between the tanycytic basal processes and the capillary loops of the hypothalamo-adenohypophyseal portal ves sels has been identified [Ldfgren, 1958;Dellmann, 1961;Kobayashi et al, 1972;Scoff et al, 1975;Rodriguez, 1972Rodriguez, , 1976. Thus, the tanycytes of the median eminence serve as a bridge between the cerebrospinal fluid and the portal vessels, and form a path way for neuroendocrine integration [review by Rodriguez, 1976].…”

Section: Introductionmentioning

confidence: 99%

A Golgi-Cox Study of Tanycytes in the Hypothalamic Region of the Third Ventricle in the Wild Rat, <i>Rattus rattus rattus</i>(L.)

Joy¹,

Sathyanesan²

1981

Cells Tissues Organs

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In the third ventricle of wild rat, Golgi-Cox-positive tanycytes of varied shape and size are arranged with their perikarya in the ependymal layer and basal processes extending into the core of the subependyma. The basal processes may be smooth and slender, or barbed and branching, and often take circuitous and overlapping courses. In some, the apical part of the perikaryon projects into the ventricle. In the arcuate region, groups of closely arranged tanycytes whose long basal processes end on the arcuate neurons and the portal vessels in the tubero-infundibular sulci are noticed. The tanycytic processes of the median eminence terminate on the portal vessels in the palisade layer. Some tanycytic processes of the mammillary recess even extend up to the ventral surface of the brain and have disc-like terminations.

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“…Using injections of HRP into the ventricular system it has been found that HRP was detectable in the extracellular space of the median eminence after 10 minutes (Wagner and Pilgrim, 1974). This finding was supported by another HRP study (Pelletier et al, 1975), although contradictory results have been obtained by a number of other authors who were only able to detect HRP intracellularly, and not within the extracellular spaces, following intraventricular injection (Brightman and Reese, 1969;Kobayashi et al, 1972;Weindel and Joynt, 1972;Brightman et al, 1975;Nakai and Naito, 1975;Flament-Durand and Brion, 1985). Uptake and accumulation of other agents have been reported to occur within the tanycytes of the third ventricle.…”

Section: Ependymamentioning

confidence: 74%

A scanning and transmission electron microscopic analysis of the cerebral aqueduct in the rabbit

Meller

Dennis

1993

Anat. Rec.

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An examination of the surface of the cerebral aqueduct with the scanning electron microscope revealed that the walls of the cerebral aqueduct were so heavily ciliated that most of the ependymal surface was obscured, yet certain specialized supraependymal structures could be discerned lying on (or embedded within) this matt of cilia. These structures were determined by transmission electron microscopy and Golgi analysis to be either macrophages, supraependymal neurons, dendrites from medial periaqueductal gray neurons, or axons of unknown origin. Some axons, which were found to contain vesicles, appeared to make synaptic contacts with ependymal cells. Using the transmission electron microscope, the ependymal lining was found to consist of two different cell types: normal ependymal cells and tanycytes which have a long tapering basal process that was observed to contact blood vessels or, more rarely, seemed to terminate in relation to neuronal elements. While there have been previous reports on the structure of the third and lateral ventricles in other species, there are limited reports in the rabbit. The present report is not only the first description for the rabbit, but it is the first complete scanning and transmission electron microscopic analysis of the cerebral aqueduct in any species.

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Uptake of peroxidase from the third ventricle by ependymal cells of the median eminence

Cited by 90 publications

References 5 publications

Localization of metallothionein in the brain of rat and mouse.

Localization of metallothionein in the brain of rat and mouse.

A Golgi-Cox Study of Tanycytes in the Hypothalamic Region of the Third Ventricle in the Wild Rat, <i>Rattus rattus rattus</i>(L.)

A scanning and transmission electron microscopic analysis of the cerebral aqueduct in the rabbit

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