Uptake, translocation and distribution of three veterinary antibiotics in Zea mays L.

Zhang, Cheng; Xue, Jianming; Yao, Feng; Liu, Yuanwang; Aly, Hesham M.; Li, Zhaojun

doi:10.1016/j.envpol.2019.03.110

Cited by 46 publications

(18 citation statements)

References 46 publications

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“…Antibiotics in soil can be absorbed and enriched by vegetables and enter the human body through the food chain, thus posing a threat to human health (Chung et al 2017;Zhang et al 2019). In this study, the contents of tetracycline antibiotics (TCs) in edible parts of brassica juncea var.…”

Section: Discussionmentioning

confidence: 99%

The Residue of Tetracycline Antibiotics in Soil and Vegetable and Its Effect On The Diversity of Soil Bacterial Community

Wang

2020

Preprint

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[Background] Tetracycline antibiotics (TCs) are a broad-spectrum antibiotic, widely used in livestock and poultry breeding. The residue of tetracycline antibiotics in animal manure may cause changes of soil microbial community. [Methods] On the basis of the investigation and analysis of TCs pollution in the soil of main vegetable bases and the livestock manure of major large-scale farms in Chongqing, China, the effects of tetracycline antibiotics on the structure and diversity of soil microbial community were investigated by high-throughput sequencing. [Results] The TCs content in soil was increased by applying livestock manure. The contents of TC, OTC and CTC in the soil under pig manure treatment were 171.07-660.20 μg·kg-1, 25.38-345.78 μg·kg-1 and 170.77-707.47 μg·kg-1, respectively. The contents of TC, OTC and CTC in the soil under the treatment of chicken manure were 166.62-353.61 μg·kg-1, 122.25-251.23 μg·kg-1 and 15.12-80.91 μg·kg-1 respectively. The content of tetracycline antibiotics (TCs) in edible parts of Brassica juncea var. gemmifera was increased after livestock manure treatment, among which pig manure had the greatest influence on the increase of TCs content, and the larger the dosage of pig manure was, the more significant the increase of TCs content was. Proteobacteria, Acidobacteria, Actinobacteria, Chioroflexi and bacteroidetes under livestock manure treatment were the dominant phyla, accounting for 85.2%-92.4% of the total abundance of soil bacteria. [Conclusions] The soil OTUs under the treatment of pig manure was higher than that under the treatment of chicken manure. Biogas residue after fermentation treatment can effectively reduce the environmental and ecological risks caused by antibiotic residues.

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Section: Discussionmentioning

confidence: 99%

The Residue of Tetracycline Antibiotics in Soil and Vegetable and Its Effect On The Diversity of Soil Bacterial Community

Wang

2020

Preprint

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“… 31 Colchicine is a selective inhibitor of the macropinocytosis pathway. 32 As a metabolic inhibitor, 33 sodium azide can affect mitochondrial oxidative phosphorylation, consume ATP, and lead to energy supply disorder. BFA is a fungal metabolite, which can destroy the structure and function of Golgi apparatus.…”

Section: Discussionmentioning

confidence: 99%

Improved Anti-Triple Negative Breast Cancer Effects of Docetaxel by RGD-Modified Lipid-Core Micelles

Chen¹,

Ni²,

Chen³

et al. 2021

IJN

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Purpose A novel RGD-modified PEGylated lipid-core micelle delivery system was designed to improve the anti-cancer effect of docetaxel on triple negative breast cancer (TNBC). Methods The tumor-targeted lipid-core micelles loaded with docetaxel were prepared and characterized. Their morphology, particle size, zeta potential, entrapment efficiency, release profiles, and targeting effects were studied. The antitumor effects of the docetaxel-loaded nano-micelles were investigated in a MDA-MB-231 cell model in vitro and a MDA-MB-231 xenograft model in vivo. Results The prepared RGD-modified docetaxel-loaded lipid-core micelles were spherical with a particle size of 16.44±1.35 nm, zeta potential of −19.24±1.24 mV, and an encapsulation efficiency of 96.52±0.43%. The drug delivery system showed sustained release properties and could significantly enhance docetaxel uptake by MDA-MB-231 tumor cells in vitro, which was proved to be a caveolae pathway mediated process requiring ATP, Golgi apparatus, and acid lysosomes. The results of the pharmacokinetic study displayed that the area under the curve of the targeted micelles was 3.2-times higher than that of docetaxel commercial injections. Furthermore, in a MDA-MB-231 tumor-bearing mice model, a higher antitumor efficacy than docetaxel commercial injections was displayed, and the safety experiments showed that the micellar material did not cause major organ damage after intravenous administration in mice. Conclusion The novel RGD-modified PEGylated lipid-core micelle delivery system significantly improved the antitumor effects and reduced the side-effects of docetaxel, providing a promising therapeutics for the treatment of TNBC.

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“…The uptake and translocation of antibiotics in maize is another example of the potential use of agricultural crops for phytoremediation (Zhang et al, 2019). A recent review illustrates the efficiency of agriculture and forestry plants in metal extraction from mercury-contaminated soils and water, and also risks of accumulation in edible tissues for animal and human health (Tiodar et al, 2021).…”

Section: Phytoremediationmentioning

confidence: 99%

NBS Framework for Agricultural Landscapes

Simelton¹,

Carew-Reid²,

Coulier³

et al. 2021

Front. Environ. Sci.

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Entering the UN Decade on Ecosystem Restoration, interventions referred to as nature-based solutions (NBS) are at the forefront of the sustainability discourse. While applied in urban, natural forest or wetland ecosystems, they are underutilized in agricultural landscapes. This paper presents a technical framework to characterise NBS in agricultural systems. NBS in the agriculture sector is proposed as “the use of natural processes or elements to improve ecosystem functions of environments and landscapes affected by agricultural practices, and to enhance livelihoods and other social and cultural functions, over various temporal and spatial scales.” The framework emerges from a review of 188 peer-reviewed articles on NBS and green infrastructure published between 2015 and 2019 and three international expert consultations organized in 2019–2020. The framework establishes four essential functions for NBS in agriculture: 1) Sustainable practices — with a focus on production; 2) Green Infrastructure — mainly for engineering purposes such as water and soil, and slope stabilization; 3) Amelioration — for restoration of conditions for plants, water, soil or air and climate change mitigation; and 4) Conservation — focusing on biodiversity and ecosystem connectivity. The framework connects the conventional divide between production and conservation to add functionality, purpose and scale in project design. The review confirmed limited evidence of NBS in agricultural systems particularly in developing country contexts, although specific technologies feature under other labels. Consultations indicated that wider adoption will require a phased approach to generate evidence, while integrating NBS in national and local policies and agricultural development strategies. The paper concludes with recommended actions required to facilitate such processes.

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Uptake, translocation and distribution of three veterinary antibiotics in Zea mays L.

Cited by 46 publications

References 46 publications

The Residue of Tetracycline Antibiotics in Soil and Vegetable and Its Effect On The Diversity of Soil Bacterial Community

The Residue of Tetracycline Antibiotics in Soil and Vegetable and Its Effect On The Diversity of Soil Bacterial Community

Improved Anti-Triple Negative Breast Cancer Effects of Docetaxel by RGD-Modified Lipid-Core Micelles

NBS Framework for Agricultural Landscapes

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