Upward trends in new, rifampicin-resistant and concurrent extrapulmonary tuberculosis cases in northern Guizhou Province of China

Chen, Ling; Fu, Xuefeng; Tian, Peng; Li, Qing; Lei, Dan; Peng, Zhiqing; Liu, Quanxian; Li, Nana; Zhang, Jianyong; Xu, Peng; Zhang, Hong

doi:10.1038/s41598-021-97595-8

Cited by 6 publications

(5 citation statements)

References 30 publications

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“…One study indicated that the prevalence of smear-positive TB in China decreased from 170/100 000 population in 1990 to 59 /100 000 population in 2010, a reduction of more than 50 percent[ 15 ]. Despite past success in controlling TB, the limited epidemiologic information available suggests that the incidence of EPTB may be increasing steadily worldwide, including in China[ 16 , 17 ].…”

Section: Discussionmentioning

confidence: 99%

Soft tissue tuberculosis detected by next-generation sequencing: A case report and review of literature

He¹,

Huang²,

Yi³

et al. 2023

World J Clin Cases

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BACKGROUND Soft tissue tuberculosis is rare and insidious, with most patients presenting with a localized enlarged mass or swelling, which may be factors associated with delayed diagnosis and treatment. In recent years, next-generation sequencing has rapidly evolved and has been successfully applied to numerous areas of basic and clinical research. A literature search revealed that the use of next-generation sequencing in the diagnosis of soft tissue tuberculosis has been rarely reported. CASE SUMMARY A 44-year-old man presented with recurrent swelling and ulcers on the left thigh. Magnetic resonance imaging suggested a soft tissue abscess. The lesion was surgically removed and tissue biopsy and culture were performed; however, no organism growth was detected. Finally, Mycobacterium tuberculosis was confirmed as the pathogen responsible for infection through next-generation sequencing analysis of the surgical specimen. The patient received a standardized anti-tuberculosis treatment and showed clinical improvement. We also performed a literature review on soft tissue tuberculosis using studies published in the past 10 years. CONCLUSION This case highlights the importance of next-generation sequencing for the early diagnosis of soft tissue tuberculosis, which can provide guidance for clinical treatment and improve prognosis.

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Section: Discussionmentioning

confidence: 99%

Soft tissue tuberculosis detected by next-generation sequencing: A case report and review of literature

He¹,

Huang²,

Yi³

et al. 2023

World J Clin Cases

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“…The level of economic development and health resources may also have an impact on the drug resistance rates in various regions. 4 , 21 , 22 For example, in Hangzhou and Ningbo, due to their developed economies and abundant health resources, the local population tend to be highly mobile, rich in social interactions, and complex in interpersonal activities, which may lead to rifampicin resistance rates at high levels. Even so, the rate of drug resistance in each municipality was decreasing year by year, and the province was on a steady downward trend.…”

Section: Discussionmentioning

confidence: 99%

“…The TB epidemic status crucially depends on regional geographic, socioeconomic, and cultural variations. 4 Therefore, the prevalence of tuberculosis in different regions also varies. For example, in Shandong Province in northern China, the rifampicin-resistance rate in newly diagnosed tuberculosis cases was 4.43%, while the rifampicin-resistance rate in retreated patients was 11.26%.…”

Section: Introductionmentioning

confidence: 99%

“… 6 In southern China’s Guizhou province, the rate of rifampicin resistance has shown an upward trend, from 12.8% in 2015 to 17.5% in 2018. 4 In other countries, such as Uganda, the rate of rifampicin resistance was 10.2% in newly treated patients and 23.5% in re-treated patients in 2018–2019. 7 In Ethiopia, the laboratory-detected rifampicin resistance rate was 6.3%.…”

Section: Introductionmentioning

confidence: 99%

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Trends of Rifampicin Resistance in Patients with Pulmonary Tuberculosis: A Longitudinal Analysis Based on Drug Resistance Screening in Eastern China Between 2015 and 2019

Ren

Chen

Zhao

et al. 2022

IDR

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To understand the trend of overall rifampicin resistance rates for tuberculosis in Zhejiang Province between 2015 and 2019. Methods: The basic demographic information of patients with tuberculosis who were screened for drug resistance in Zhejiang Province between January 1, 2015 and December 31, 2019 was collected through the national Tuberculosis Information Management System. The data were processed and analyzed using IBM SPSS 26.0 and GeoDa 1.14 software. Results:The total rifampicin resistance rate was 5.9% in 53,893 validated cases of drug resistance screening conducted in patients with pulmonary tuberculosis in Zhejiang Province during the study period. There was a decreasing trend in the rifampicin resistance rate in both initial and re-treated patients (P<0.001), but the rifampicin resistance rate was higher in re-treated TB patients than in TB patients receiving their initial treatment (11.4% vs 4.2%). The rate of drug resistance steadily decreased in all prefectures, and there was a significant upward trend in the use of the Xpert MTB/RIF rapid assay. An increasing trend was also identified in the rate of rifampicin and ofloxacin co-resistance (P<0.001). Conclusion:The overall rate of rifampin resistance in patients with tuberculosis in Zhejiang Province in the past five years has shown a decreasing trend, but the rate of resistance to ofloxacin was high. Resistance testing to fluoroquinolones should be carried out as early as possible in patients whose diagnosis results indicate rifampin resistance, and more effective second-line treatment plans should be developed based on the results of this testing.

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“…Demographic and clinical data of patients were collected. The data collection and procedures were described previously ( 4 ). Any information related to patient identity was filtered to ensure the data used in this study were anonymous.…”

Section: Methodsmentioning

confidence: 99%

Investigation of 3-year inpatient TB cases in Zunyi, China: Increased TB burden but improved bacteriological diagnosis

Chen

Wang

Jia

et al. 2022

Front. Public Health

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BackgroundAs one of the top three high tuberculosis (TB) burden countries, China is a country where the overall TB incidence continues to decline. However, due to its large population and area, the increased TB burden exists in regional areas.MethodsThis retrospective study analyzed local inpatient pulmonary TB cases in the Affiliated Hospital of Zunyi Medical University (AHZMU) from January 2016 to December 2018 in a high TB incidence and economically-less-developed area of China. Four methods, acid-fast bacilli stain, culture, Xpert and LAMP, were used to detect Mycobacterium tuberculosis (M.tb), while proportional method and Xpert were used to identify rifampicin-resistant TB (RR-TB). Case number, treatment history, M.tb confirmed TB and rifampicin resistant proportion were analyzed to investigate the local TB epidemic.ResultsTotal 3,910 local inpatient cases with pulmonary TB were admitted to AHZMU during this study period. The annual numbers of total TB cases increased 26.4% (from 1,173 to 1,483), while new cases increased 29.6% (from 936 to 1,213) and RR-TB cases increased 2.7 times (from 31 to 84). Meanwhile, the percentage of previously treated cases declined from 20.2 to 18.2% and the M.tb confirmed TB proportion increased from 34.7 to 49.7%.ConclusionThe elevated M.tb confirmed TB proportion and the declined percentage of previously treated cases indicated the improved TB diagnosis and treatment of AHZMU. However, the increasing number of total TB cases, new and RR-TB cases showed an upward trend and increased TB burden in a relatively underdeveloped area of China.

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Upward trends in new, rifampicin-resistant and concurrent extrapulmonary tuberculosis cases in northern Guizhou Province of China

Cited by 6 publications

References 30 publications

Soft tissue tuberculosis detected by next-generation sequencing: A case report and review of literature

Soft tissue tuberculosis detected by next-generation sequencing: A case report and review of literature

Trends of Rifampicin Resistance in Patients with Pulmonary Tuberculosis: A Longitudinal Analysis Based on Drug Resistance Screening in Eastern China Between 2015 and 2019

Investigation of 3-year inpatient TB cases in Zunyi, China: Increased TB burden but improved bacteriological diagnosis

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