Urachal carcinoma: A case of a rare neoplasm

Moreira, Ilídia; Coelho, Sara; Rodrigues, Ângelo; Patrão, Ana Sofia; Maurício, Maria Joaquina

doi:10.1016/j.currproblcancer.2021.100711

Cited by 5 publications

(4 citation statements)

References 13 publications

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“…The urachus is a fibrous cord that connects the urinary bladder to the umbilicus. 1 The urachus is formed during fetal development and whose remnant may persist throughout life. After birth, the urachus is known as the median umbilical ligament that joins the umbilicus to the dome of the bladder.…”

Section: Introductionmentioning

confidence: 99%

“…After birth, the urachus is known as the median umbilical ligament that joins the umbilicus to the dome of the bladder. 1 This median umbilical ligament can transform into carcinoma, also referred to as urachal cancer. Urachal cancer comprises 0.3% of all invasive bladder cancers along with urachal cancer accounting for approximately 0.01% of all cancers diagnosed.…”

Section: Introductionmentioning

confidence: 99%

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A remnant never forgotten: the utility of circulating tumor DNA in treatment guidance of urachal cancer

Grant,

Benjamin,

Cramer

et al. 2024

Ther Adv Med Oncol

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Urachal cancer is a rare malignancy of the urachus that is treated with surgical resection if localized and systemic chemotherapy for metastatic disease. Circulating tumor DNA (ctDNA) is a single-stranded or double-stranded DNA released by tumor cells into the blood and harbored the mutations of the original tumor, shedding new light on molecular diagnosis and monitoring of cancer. We report a case of resected localized urachal cancer with clear surgical margins and negative lymph node dissection but elevated ctDNA that progressed to metastatic disease. We also highlight the possibility of using ctDNA levels to assist in adjuvant therapy.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A remnant never forgotten: the utility of circulating tumor DNA in treatment guidance of urachal cancer

Grant,

Benjamin,

Cramer

et al. 2024

Ther Adv Med Oncol

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“…Urachal carcinoma is an infrequent neoplasm that originates from the urachal ligament, with an approximate prevalence between 0.01% to 0.02% of all cancers in adults worldwide, more frequent between the 5th and 6th decades, with a male-to-female ratio of 1.4-1.6:1 [ 1 - 2 ]. It was first described by Hue and Jacquin in 1863 [ 3 ] and incorporated into the World Health Organization in the classification of urinary tract tumors in 2004.…”

Section: Introductionmentioning

confidence: 99%

“…It is worth mentioning that neoplasms can arise in any of these portions [ 4 ]. The most recurrent histological type reported is adenocarcinoma [ 1 ]. This unusual hidden location is the reason why symptoms such as hematuria and pain come into sight in advanced stages, resulting in about a third of patients having metastases at the time of diagnosis, which is associated, as expected, with a poor prognosis even in the short term [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Acute Glomerulonephritis as a Paraneoplastic Syndrome Secondary to Urachal Adenocarcinoma: An Unknown Entity

Bermúdez Barrientos,

Ramos Portales,

Mendoza Villalobos

et al. 2024

Cureus

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Urachal carcinoma is an uncommon malignancy with a peculiar biomolecular characterization and therefore a complex approach. It was incorporated by the World Health Organization in 2004 in the tumors of the urinary system classification. This neoplasm is generally diagnosed in advanced stages. The standard treatment is surgical, however, due to the rarity and relatively late clinical manifestation of urachal carcinomas, the survival data are mostly case reports, as well as information about medical-surgical treatment based on evidence.The data used were extracted from both the physical and electronic clinical records. Among atypical presentations reported in the literature, we report a case of urachal adenocarcinoma with simultaneous glomerulonephritis as a paraneoplastic syndrome of which there is no report to date. Surgery was carried out in our patient, unfortunately with lifetime morbidity from kidney function replacement secondary to kidney function damage by glomerulonephritis, despite previous immunosuppression treatment for rapidly progressive glomerulonephritis. It is worth mentioning that if the initial diagnosis represents a clinical challenge, treatment is even more complex, given the little information that currently exists about it.Urachal carcinoma is a diagnostic and treatment challenge. Up to now, surgery has been the treatment of choice in localized or locally advanced disease, however, with a high morbidity for the patient.

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2022

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Urachal carcinoma: A case of a rare neoplasm

Cited by 5 publications

References 13 publications

A remnant never forgotten: the utility of circulating tumor DNA in treatment guidance of urachal cancer

A remnant never forgotten: the utility of circulating tumor DNA in treatment guidance of urachal cancer

Acute Glomerulonephritis as a Paraneoplastic Syndrome Secondary to Urachal Adenocarcinoma: An Unknown Entity

Antineoplastics

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