Uranium(VI) and Copper(II) Complexes of Carboxylate, Thiocarboxylate and Dithiocarboxylate Derivatives of 1-Phenyl-3-Methyl-2-Pyrazolin-5-One

Abstract

The metal chelates formed by 4-alkylcarboxylate, 4-alkoxythiocarboxylate and 4-alkyldithiocarboxylate derivatives of l-phenyl-3-methyl-2-pyrazolin-5-one with copper(I1) and uranium(V1) have prepared. The complexes were characterized by elemental analyses, IR, UV and ' H NMR spectral studies. All the complexes have a metal : ligand ratio of 1:2.

Structure-activity relationships of pyrazole-4-carbodithioates as antibacterials against methicillin–resistant Staphylococcus aureus

“…Alternatively, metal chelation by the 4-carbodithioate and neighboring OH group may be involved. 18 While limited selectivity (maximum 16-fold) for MRSA over eukaryotic HKC-8 cells was achieved with the analogs explored here, further increases seem possible with a larger analog set. Studies to fully elucidate the anti-MRSA mechanism and identify the discrete intracellular targets using such selective analogs would undoubtedly prove insightful.…”