Uranyl Nitrate: 91-Day Exposure and Recovery Studies in the Male New Zealand White Rabbit

Gilman, Andrew P.; Moss, Michael A.; Villeneuve, D. C.; Secours, V. E.; Yagminas, Al; Tracy, B.L.; Quinn, J.M.; Long, George Washington De; Valli, V. E.

doi:10.1006/toxs.1997.2369

Cited by 19 publications

(21 citation statements)

References 6 publications

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“…For a large mammal of 1000 kg (e.g., moose), the corresponding values are 11 mg U d ÿ1 or 0.01 mg U kg ÿ1 d ÿ1 . Gilman et al (1998c) reported the LOEC was 1.36 mg U kg ÿ1 body mass d ÿ1 . The next series of papers use rats and mice Paternain et al, 1989;Domingo et al, 1989a).…”

Section: Dosage By Ingestion (Mg U Kg ÿ1 Body Mass D ÿ1 )mentioning

confidence: 98%

“…Gilman et al (1998b,c) reported low concentrations in kidney (0.18 and 0.2 mg U kg ÿ1 kidney) that were associated with LOEC for renal damage. Gilman et al (1998c) showed the kidney concentration of 0.18 mg U kg ÿ1 kidney in rabbits was associated with a measured intake rate of 1.36 mg U kg ÿ1 body mass d ÿ1 . The implied transfer ratio from intake rate to kidney tissue concentration is 0.13 d. Gilman et al (1998b) used rats, where the kidney concentration of about 0.2 mg U kg ÿ1 kidney was associated with a measured intake rate of 0.06 mg U kg ÿ1 body mass d ÿ1 .…”

Section: Toxicity Based On Kidney Tissue Concentrations (Mg U Kg ÿ1 Kmentioning

confidence: 98%

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Derivation of ecotoxicity thresholds for uranium

Sheppard¹,

Sheppard²,

Gallerand

et al. 2005

Journal of Environmental Radioactivity

209

105

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Section: Dosage By Ingestion (Mg U Kg ÿ1 Body Mass D ÿ1 )mentioning

confidence: 98%

Section: Toxicity Based On Kidney Tissue Concentrations (Mg U Kg ÿ1 Kmentioning

confidence: 98%

Derivation of ecotoxicity thresholds for uranium

Sheppard¹,

Sheppard²,

Gallerand

et al. 2005

Journal of Environmental Radioactivity

209

105

View full text Add to dashboard Cite

“…The most serious health hazard associated with the uranium is lung cancer, due to the inhalation of uranium decay product; radon, for example, is more radioactive than the elemental uranium by a factor of 10000 (Shawky et al, 2002;Kathern and Moore, 1986;Kathern et al, 1989). Although the kidney is considered to be the primary target in both acute and chronic situations (Gilman et al, 1998;Legget, 1989), experimental evidence suggests that the respiratory and reproductive system are also affected by exposure (UNSCEAR, 2000).…”

Section: Introductionmentioning

confidence: 97%

Trace Level Determination of U, Zn, Cd, Pb and Cu in Drinking Water Samples

Kumar

Singh

Mahajan

2006

Environ Monit Assess

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The concentration of uranium has been assessed in drinking water samples collected from different locations in Bathinda district, Punjab, India. The water samples are taken from hand pumps and tube wells. Uranium is determined using fission track technique. Uranium concentration in the water samples varies from 2.23+/- 0.05 to 87.05+/- 0.29 microg/L. These values are compared with safe limit values recommended for drinking water. The uranium concentration in almost all drinking water samples is found to be more than the safe limit. Analysis of some heavy metals viz. Zn, Cd, Pb and Cu in water is made. The concentration of sodium, potassium, calcium, magnesium, chlorine and total hardness along with the pH value and conductivity of the water samples are measured. Some of the samples show stunningly high values of these parameters.

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“…The absorbed uranium fraction rapidly enters the bloodstream and is distributed to the kidney and bones, where it tends to accumulate. The kidney is recognized as the primary target organ for uranium chemical toxicity in both experimental animals and human studies (Domingo et al 1989;Gilman et al 1998;Zamora et al 1998). Taking into account the common safety factors, the World Health Organization (WHO) established a Tolerable Daily Intake (TDI) of 0.6 lg/kg of body weight per day for soluble uranium (WHO 2005) based on oral ingestion.…”

Section: Introductionmentioning

confidence: 99%

Uranium in vegetable foodstuffs: should residents near the Cunha Baixa uranium mine site (Central Northern Portugal) be concerned?

Neves¹,

Abreu²,

Figueirêdo

2011

Environ Geochem Health

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Large uranium accumulations in vegetable foodstuffs may present risks of human health if they are consumed. The objective of this study was to evaluate the uranium concentrations in different vegetable foodstuffs and grown in agricultural soils, which are then consumed by the residents of the village of Cunha Baixa (Portugal),--located in an former uranium mining area. This study was conducted to address concerns expressed by the local farmers as well as to provide data for uranium-related health risk assessments for the area. Soils, irrigation water and edible tissues of lettuce, potato, green bean, carrot, cabbage, apple and maize (Latuca sativa L., Solanum tuberosum L., Phaseolus vulgaris L., Daucus carota L., Brassica oleracea L., Malus domestica Borkh, Zea mays L., respectively) were sampled and uranium determined. High uranium concentrations were found in some soils (U(total) > 50 mg/kg), in irrigation waters (218 to 1,035 μg/l) and in some vegetable foodstuffs (up to 234, 110, 30, 26, 22, 16 and 1.6 μg/kg fresh weight for lettuce, potato with peel, green bean pods, cabbage, corn, carrot and apple, respectively). However, the results of the toxicity hazard analysis were reassuring the estimated level of uranium exposure through the ingestion of these vegetable foodstuffs was low, suggesting no chemical health risk (hazard quotient <1) to this uranium exposure pathway for a local residents during their lifetime, even for the most sensitive part of the population (child).

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Uranyl Nitrate: 91-Day Exposure and Recovery Studies in the Male New Zealand White Rabbit

Cited by 19 publications

References 6 publications

Derivation of ecotoxicity thresholds for uranium

Derivation of ecotoxicity thresholds for uranium

Trace Level Determination of U, Zn, Cd, Pb and Cu in Drinking Water Samples

Uranium in vegetable foodstuffs: should residents near the Cunha Baixa uranium mine site (Central Northern Portugal) be concerned?

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