The contradictions that exist today between a reasonable balance of planning, communication, industrial, environmental processes and the organization of the urban planning structure of a megapolis are formed in the orbit of current challenges for Russia. The author examines new concepts aimed at creating international transport and logistics corridors and scientific and production clusters in accordance with the strategy of neo-industrialization and the draft Urban Planning Doctrine of Russia developed by the Russian Academy of Architecture and Construction Sciences. Using the example of the Volga region megapolis Greater Samara, the following are considered: the basic urban planning principles for regulating the transformation of the suburbs of the megapolis; spatial structure of multihub systems. Promising models of the supporting framework of territories with scientific and practical organization of space are proposed, considered according to the spheres of their action: architectural, urban planning, management, environmental, economic. The author relies on the scientific works of architects, urban planners, economic geographers, urban ecologists and other specialists studying urban processes.