This paper aims to provide a framework for policy-makers and transportation and urban design professionals to evaluate alternative urban plans and infrastructure design, allowing them to select a set of locally relevant indicators to help assess scenarios considering sustainable development and overall system performance improvement in line with specific project goals. Using methods of systematic review, content analysis, multi-criteria analysis, and expert consultation, a three-level goal system is proposed, leading to the generation of 64 Key Performance Indicators (KPIs), both qualitative and quantitative, and an indicator set of 227 items. To allow stakeholders to apply their own set of indicators, the approaches and tools of measuring these indicators as well as the ways of using this indicator set are presented to assist decision-makers in evaluating and choosing optimal plans and designs.