Urban-Rural estimation of hepatitis c virus infection sero-prevalence in North Central Nigeria

Forbi, J C; Pietzsch, John; Olaleye, VO; Forbi, TD; Gr, Pennap; Esona,; Adoga, MP; Agwale, SM

doi:10.4314/eajph.v7i4.64770

Cited by 6 publications

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“…The very high prevalence among children may suggest vertical as well horizontal transmission especially as the virus is not vaccine preventable. Similar to our observation, some researchers have reported highest infection rates among those aged 21 -40 years [15,20,21] and 26 -35 years [10]. The high prevalence rates found among young adults maybe partly be a reflection of cumulative risk exposure to the virus with age.…”

Section: Discussionsupporting

confidence: 90%

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2016

The Asia Journal of Applied Microbiology

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Hepatitis C virus (HCV) is an emerging public health problem inKeywords: HCV, Anti-HCV, Prevalence, Masaka, Nigeria. Contribution/ OriginalityThis study has contributed in documenting the prevalence of the infectin in Masaka, Nigeria using chromatographic rapid test kit and has used the Chi square statistical test. The study is one of the very few studies which have investigated the prevalence of HCV infection in North Central, Nigeria. This paper has contributed in logical analysis and in estimating the prevalence and risk factors of the infection in Masaka. The study documented a relatively high overall prevalence of the infection. It is associated with educational level and not associated with age, gender, occupation and marital status.

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Section: Discussionsupporting

confidence: 90%

“…Some researchers have noted that infection with HCV is higher in rural than urban areas [3,15]. Poverty has also been linked to the spread of common diseases [25].…”

Section: Discussionmentioning

confidence: 99%

Untitled

2016

The Asia Journal of Applied Microbiology

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“…The differences in prevalence across the studies may be due to differences in demographics, socioeconomic status, risk behaviour, and the method of testing employed. The low prevalence in this study may also be due to the fact that the subjects live in Lagos which is an urban area, because the prevalence of HCV has been reported to be higher in rural versus urban areas (17).…”

Section: Discussionmentioning

confidence: 74%

Prevalence of Hepatitis C virus and HIV among adults presenting for health screening in Lagos

Oshun¹,

Odeghe²

2019

Af J Clin Exp Micro

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Background: Hepatitis C virus is an important cause of chronic liver disease with 71 million people worldwide living with chronic HCV infection as at 2015. Nigeria has the second largest burden of HIV in Africa, with 3.2 million Nigerians living with HIV/AIDS in 2016. Most people infected with the hepatitis C virus are asymptomatic and often unaware of their infection. This study was conducted to determine the prevalence of and risk factors for HCV and HIV infections among apparently healthy individuals in Lagos. Materials and methods: This was a retrospective study in which the prevalence of hepatitis C virus antibodies and HIV was determined among apparently healthy individuals who presented for health screening at a private laboratory facility in Lagos from May 2014 to June 2016. The health records of those who met the inclusion criteria were systematically reviewed to extract demographic and clinical information including age, sex, history of blood transfusion, alcohol use, surgery and results of serological tests for antibodies to hepatitis C virus and HIV. Results: Out of 1379 apparently healthy individuals included in the study, 60.1% were male. The prevalence rate of hepatitis C virus (HCV antibody) and HIV were 0.7% and 2% respectively. Hepatitis C virus infection was not significantly associated with history of blood transfusion, alcohol use, prior surgery and age. HIV infection was significantly associated with only prior history of surgery (OR 4.72, p=0.02). Conclusion: In this study of apparently healthy Nigerians, the prevalence rates of HCV and HIV were low, no documented HCV-HIV co-infection and surgery was a risk factor for HIV infection. Screening of healthy individuals for HIV and HCV infection is very important to determine those who are infected and need to access treatment.

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“…The same finding was found in a near country. 47 This may be explained by the low level of education in rural settings compared with urban settings; this low level of education may be related to low awareness of the risk of HCV transmission. This underlines the need for specific interventions for rural settings in Cameroon.…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of hepatitis C virus infection in Cameroon: a systematic review and meta-analysis

et al. 2017

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ObjectiveBetter knowledge of hepatitis C virus (HCV) seroprevalence at the national level can help to implement pertinent strategies to address the HCV-related burden. The aim of this paper was to estimate the seroprevalence of HCV infection in Cameroon.DesignSystematic review and meta-analysis.ParticipantsPeople residing in Cameroon.Data sourcesElectronic databases including PubMed/MEDLINE, AJOL, WHO-Afro Library, Africa Index Medicus, National Institute of Statistics and National AIDS Control Committee, Cameroon from 1 January 2000 to 15 December 2016 were searched. English and French languages papers were considered. Two independent investigators selected studies. The methodological quality of the studies was assessed using the Newcastle–Ottawa scale.Results31 studies including 36 407 individuals were finally considered. There was no national representative study. The overall pooled prevalence was 6.5% (95% CI 4.5% to 8.8%; I²=98.3%). A sensitivity analysis of individuals at low risk of HCV infection showed a pooled prevalence of 3.6% (95% CI 2.3% to 5.2%, I²=97.7%, 18 studies) among 22 860 individuals (general population, blood donors and pregnant women), which was higher than for a high-risk population (healthcare workers and people with other identified comorbidities), 12.2% (95% CI 4.9% to 22.2%; I²=98.3%, 13 studies); p=0.018. The prevalence was higher in the East region, in rural settings, and when using an enzyme immunoassay technique for detecting HCV antibodies. Sex, sites, study period, sample size, timing of data collection and methodological quality of studies were not sources of heterogeneity.LimitationOne-third of studies (29.0%) had a low risk bias in their methodology and most were facility-based (87.1%).ConclusionThe seroprevalence of HCV infection in Cameroon indicates the need for comprehensive and effective strategies to interrupt HCV transmission in the Cameroonian population. Specific attention is needed for the East region of the country, rural settings and high-risk populations. A national representative study is needed to provide better estimates.

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Urban-Rural estimation of hepatitis c virus infection sero-prevalence in North Central Nigeria

Cited by 6 publications

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Prevalence of Hepatitis C virus and HIV among adults presenting for health screening in Lagos

Seroprevalence of hepatitis C virus infection in Cameroon: a systematic review and meta-analysis

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