The rapid development observed in metropolitan cities affects the spatial interaction between regions and urban cluster settlements, leading to the fiscal growth of suburbs. This study is therefore, aimed to examine and analyze the spatial integration, urban agglomeration, economic growth and formation of the social territorial structures in the Mamminasata Metropolitan suburb using a combination of qualitative and quantitative approaches. Meanwhile, data were obtained through observation, surveys and documentation studies. Furthermore, the results showed that an elevation in the pattern of urban activities elicited changes parameters assessed which lead to economic growth in the suburbs of Mamminasata Metropolitan. This finding further indicated that spatial integration an urban agglomeration and the increase of activity, led to land tenure inequality and differences in adaptation between migrants and the local community. However, changes in spatial use influenced the structure and pattern of space, therefore, causing the formation of social territorial structures in the area.