The 2008 economic recession may have affected health‐related indicators differently depending on the living environment. We analyze health‐related indicators in Spain using data from four Spanish health surveys (2006, 2011, 2014, and 2017, 95 924 individuals aged ≥16 years). In 2006–2011, physical activity decreased among men and women, while in 2006–2017, physical activity only decreased among urban women. Daily vegetable intake, except in rural women, increased in 2006–2011 but decreased in 2006–2017 in all groups. Smoking decreased among urban women in 2006–2011 and 2006–2014 but only decreased among men, and even increased among rural women, in 2006–2017. In 2006–2017, obesity increased among men and urban women, good self‐rated health status increased in all groups and flu vaccination declined. Blood pressure and cholesterol control decreased in urban women in 2006–2011 but increased in 2006–2017 in all groups, as well as mammographic and cytological control. Our findings highlight the differential impact of the economic recession on health‐related lifestyles according to sex and place of residence, underscoring the need for targeted health policies to address evolving health disparities over time.