Urea Hydrogen Peroxide and Ethyl Lactate, an Eco-Friendly Combo System in the Direct C(sp²)–H Bond Selenylation of Imidazo[2,1-b]thiazole and Related Structures

Abstract

Herein, we describe a urea hydrogen peroxide-mediated sustainable protocol for the synthesis of selenylated imidazo­[2,1-b]­thiazole by using half molar equivalent diorganyl diselenides in ethyl lactate as a greener solvent. The reaction features high yields, easy performance on gram scale, metal-free conditions, as well as applicability to imidazopyridine and imidazopyrimidine.

Selenium-Containing (Hetero)Aryl Hybrids as Potential Antileishmanial Drug Candidates: In Vitro Screening against L. amazonensis

“…These heterocyclic compounds have been utilized to access structurally diverse selenium-substituted (hetero)aryl hybrids MRK101-108, 111, and 113 (Figure 1) using our previously established sustainable routes. [34][35][36][37][38][39][40]. [34][35][36][37][38][39][40] used in this study.…”

“…Thus, in line with our continuous interest in discovering and developing new sustainable, efficient methodologies for biologically relevant organoselenides and their biological evaluation [17,19,[34][35][36][37][38], this article aims to thoroughly examine the synthetic approaches used to create novel chemical compounds for combating leishmaniasis. Herein, we report the in vitro investigation of the antileishmanial potential of selenium-substituted (hetero)aryl hybrids (indole, coumarin, chromone, oxadiazole, imidazo[1,2-a]pyridine, Imidazo[2,1-b]thiazole, and oxazole, among others) seeking to assess their efficacy and potential for treating this parasitic disease, with a focus on understanding the relationships between compound structures and their biological activity.…”

“…Figure1. Chemical structure of selenium-substituted (hetero)aryl hybrids[34][35][36][37][38][39][40] used in this study.…”

Selenium-Containing (Hetero)Aryl Hybrids as Potential Antileishmanial Drug Candidates: In vitro Screening Against L. amazonensis

“…These heterocyclic compounds have been utilized to access structurally diverse selenium substituted (hetero)aryl hybrids MRK101-108, 111, 113 (Figure 1) using our previously established sustainable routes. [34][35][36][37][38][39][40]. [34][35][36][37][38][39][40], used in this study.…”

“…Thus, in line with our continuous interest in discovering and developing new sustainable, efficient methodologies for biologically relevant organoselenides and their biological evaluation [17,19,[34][35][36][37][38], this article aims to thoroughly examine the synthetic approaches used to create novel chemical compounds for combating leishmaniasis. Herein we report the in vitro investigation of antileishmanial potential of selenium substituted (hetero)aryl hybrids (indole, coumarin, chromone, oxadiazole, imidazo[1,2-a]pyridine, Imidazo[2,1-b]thiazole and oxazole, among others) seeking to assess their efficacy and potential for treating this parasitic disease, with a focus on understanding the relationships between compound structures and their biological activity.…”