Urea/thiourea derivatives of quinazolinone–lysine conjugates: Synthesis and structure–activity relationships of a new series of antimicrobials

Synthesis, cytotoxicity and antimicrobial activity of thiourea derivatives incorporating 3-(trifluoromethyl)phenyl moiety

“…derivatives (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) and N-alkyl- [3-(trifluoromethyl)phenyl]thiourea derivatives (21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31) M A N U S C R I P T…”

Synthesis, characterization and antibacterial study of tripodal tris-(N-benzoylthioureido)ethylamine

“…A relatively higher antibacterial activities were displayed by the presence of oxygen atom in thiourea derivatives such as acetyl thiourea. The nucleophilic nature of the sulfur and oxygen as well as their ability to form a hydrogen bond are said to play a role to increased the activity of the compound [13]. Thiourea is also a versatile ligand to coordinate with a range of metal centre through the oxygen, sulphur and nitrogen donors [14][15][16].…”

Inhibition of Urease Enzyme Activity by Urea and Thiourea Derivatives of Dipeptides Conjugated 2, 3-Dichlorophenyl Piperazine

“…Their effects on a variety of metabolic and physiological ramifications are among the most investigated topics in biomedical sciences. In addition, taking into consideration the need of more urease inhibitors and afore mentioned biological significance of piperazine, ureas/thioureas, amino acids functions and coupled with our research focused on the development of novel potential bioactive agents [20][21][22][23]. The aim of this report was to develop some new antiurease agents with better therapeutic potential.…”

“…The literature on urease inhibitors with possible applications in medicine showed urea derivatives and heterocyclic compounds constitute the major classes of structures with such activity. These ureas/thioureas display a wide range of biological activities including antibacterial, antifungal, antitubercular, antithyroid, anthelmintic, antidiabetic, anticancer, insecticidal, herbicidal and antimalarial properties [10][11][12][13][14].…”