Ureaplasma spp. in male infertility and its relationship with semen quality and seminal plasma components

Zhou, Yun Heng; Hong, Xia; Shi, Xiao Xing; Liu, Yang

doi:10.1016/j.jmii.2016.09.004

Cited by 43 publications

(33 citation statements)

References 28 publications

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“…Thirty‐five studies used PCR or culture to isolate specific bacteria, namely Chlamydia trachomatis , Ureaplasma spp. and Mycoplasma spp 9,19,51,52,55,60‐89 . The PCR technique identified C trachomatis in 15 studies with reported prevalence of between 0.3% and 43.3% in infertile men, which is in contrast to the culture technique where this species was not identified in any of the studies (0/20).…”

Section: Evidence Synthesismentioning

confidence: 88%

The semen microbiome and its impact on sperm function and male fertility: A systematic review and meta‐analysis

et al. 2020

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Background Male factor is attributable in up to 50% of cases of infertility. In vitro studies demonstrate that bacteria can negatively impact sperm function. The use of next‐generation sequencing techniques has provided a better understanding of the human microbiome, and dysbiosis has been reported to impact health. Evidence regarding the impact of the semen microbiome on sperm function and fertility remains conflicting. Materials and methods A systematic search was conducted in accordance with the Preferred Reporting Items for Reviews and Meta‐analysis (PRISMA) statement. The databases MEDLINE, OVID and PubMed were searched to identify English language studies related to the identification of bacteria in the semen of infertile and fertile men, between 1992 and 2019. Fifty‐five observational studies were included, with 51 299 subjects. We included studies identifying bacteria using next‐generation sequencing, culture or polymerase chain reaction. Results The semen microbiome was rich and diverse in both fertile and infertile men. Three NGS studies reported clustering of the seminal microbiome with a predominant species. Lactobacillus and Prevotella were dominant in respective clusters. Lactobacillus was associated with improvements in semen parameters. Prevotella appeared to exert a negative effect on sperm quality. Bacteriospermia negatively impacted sperm concentration and progressive motility, and DNA fragmentation index (DFI; MD: 3.518, 95% CI: 0.907 to 6.129, P = .008). There was an increased prevalence of ureaplasma urealyticum in infertile men (OR: 2.25, 95% CI: 1.47‐3.46). Ureaplasma urealyticum negatively impacted concentration and morphology. There was no difference in the prevalence of chlamydia trachomatis between fertile and infertile men and no significant impact on semen parameters. Enterococcus faecalis negatively impacted total motility, and Mycoplasma hominis negatively impacted concentration, PM and morphology. Discussion and conclusions Ureaplasma urealyticum, Enterococcus faecalis, Mycoplasma hominis and Prevotella negatively impact semen parameters, whereas Lactobacillus appears to protect sperm quality. These findings may facilitate the development of novel therapies (eg probiotics), although the evidence regarding the impact of the seminal microbiome on fertility is inconclusive and further studies are needed to investigate this association.

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Section: Evidence Synthesismentioning

confidence: 88%

The semen microbiome and its impact on sperm function and male fertility: A systematic review and meta‐analysis

et al. 2020

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“…It appears that in infertile men, U. urealyticum is more prevalent than U. parvum (Zeighami, Peerayeh, Yazdi, & Sorouri, 2009;Zhang et al, 2014;Zhou, Ma, Shi, & Liu, 2018) indicating that U. urealyticum has a clearly higher causative role in infertile men. Nevertheless, U. urealyticum is also increasingly identified to cause adverse pregnancy outcomes (Capoccia, Greub, & Baud, 2013) and both U. urealyticum and U. parvum are implicated in chorioamnionitis (Sweeney, Dando, Kallapur, & Knox, 2017).…”

Section: Ureaplasma Urealyticummentioning

confidence: 99%

The role of infections and leukocytes in male infertility

2020

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Oxidative stress is preempted by an adequate level of antioxidants, which scavenge oxidants when they are produced in excess by different sources, including leukocytes and immature spermatozoa. Enzymatic antioxidants, such as superoxide dismutase, catalase and glutathione peroxidase, and several nonenzymatic antioxidants (pro teins, vitamins and minerals), working as oxidant scavengers and cofactors of en zymatic antioxidants have been identified in seminal plasma. The total antioxidant capacity (TAC) is a diagnostic test that can be utilised in the male infertility workup. TAC measures the amount of total antioxidants in seminal plasma. Therefore, it pro vides an assessment of the reductive potential in seminal plasma. Several studies have investigated the diagnostic application of TAC in various andrology conditions. There is substantial evidence in the literature to show that infertile patients have lower seminal TAC in comparison with fertile men. Moreover, there is a positive cor relation between TAC and seminal parameters, such as sperm concentration, motility and morphology. Evaluation of TAC together with reactive oxygen species (ROS) and sperm DNA fragmentation index (DFI) may be beneficial in the diagnosis of male infertility.

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“…Chlamydia trachomatis [110] and Ureaplasma sp. [111] infections are reported to affect sperm motility. Similarly, Burrello et al [112] reported that infections caused by Candida albicans, a pathogenic yeast, decreased sperm motility significantly by reducing mitochondrial membrane potential and increasing apoptosis of human spermatozoa in vitro.…”

Section: Infections and Sperm Motilitymentioning

confidence: 99%

Current Insights and Latest Updates in Sperm Motility and Associated Applications in Assisted Reproduction

et al. 2020

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Spermatozoon is a motile cell with a special ability to travel through the woman’s reproductive tract and fertilize an oocyte. To reach and penetrate the oocyte, spermatozoa should possess progressive motility. Therefore, motility is an important parameter during both natural and assisted conception. The global trend of progressive reduction in the number and motility of healthy spermatozoa in the ejaculate is associated with increased risk of infertility. Therefore, developing approaches for maintaining or enhancing human sperm motility has been an important area of investigation. In this review we discuss the physiology of sperm, molecular pathways regulating sperm motility, risk factors affecting sperm motility, and the role of sperm motility in fertility outcomes. In addition, we discuss various pharmacological agents and biomolecules that can enhance sperm motility in vitro and in vivo conditions to improve assisted reproductive technology (ART) outcomes. This article opens dialogs to help toxicologists, clinicians, andrologists, and embryologists in understanding the mechanism of factors influencing sperm motility and various management strategies to improve treatment outcomes.

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Ureaplasma spp. in male infertility and its relationship with semen quality and seminal plasma components

Abstract: The infection of Ureaplasma spp. plays an important pathogenic role in male infertility. UPA has higher pathogenicity on the progressive motility and the secretary function of epididymis than UUR.

Cited by 43 publications

References 28 publications

The semen microbiome and its impact on sperm function and male fertility: A systematic review and meta‐analysis

The semen microbiome and its impact on sperm function and male fertility: A systematic review and meta‐analysis

The role of infections and leukocytes in male infertility

Current Insights and Latest Updates in Sperm Motility and Associated Applications in Assisted Reproduction

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