Ureaplasma urealyticum Infection of the Placenta in Pregnancies That Ended Prematurely

Kundsin, Ruth B.; Leviton, Alan; Allred, Elizabeth N.; Poulin, Sharon A.

doi:10.1016/0029-7844(95)00376-2

Cited by 73 publications

(48 citation statements)

References 17 publications

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“…Robertson et al (42) found a connection between colonisation of vagina with U. urealyticum and premature labor, and Donders et al (7) found that bacterial vaginosis and presence of U. urealyticum and M. hominis in the vagina were associated with an increased risk of early miscarriage. U. urealyticum has also been found in the placenta, associated to perinatal morbidity and mortality and preterm labor (43,44). However, colonisation of the uterine cervix with U. urealyticum is quite common in women who did not experience any problem during pregnancy (45), so its possible role in induction of miscarriage is questionable.…”

Section: Discussionmentioning

confidence: 99%

Possible role of bacterial and viral infections in miscarriages

Matovina

Husnjak

Milutin

et al. 2004

Fertility and Sterility

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CapsuleWith the use of polymerase chain reaction, human papillomavirus and Chlamydia trachomatis were detected in 7.4 % and 1 % of placental samples from miscarriages, respectively. 2 Structured abstract and key wordsObjective: In order to determine the role of infections in miscarriages, chorionic villi from aborted material were subjected to cytogenetic evaluation and analysed for the presence of Chlamydia trachomatis, Ureaplasma urealyticum, Mycoplasma hominis, human cytomegalovirus (HCMV), adeno-associated virus (AAV) and human papillomaviruses (HPV).Design: Retrospective study. Setting: University hospital and academic research institution.Main Outcome Measure(s): Karyotyping and detection of bacterial and viral DNA by means of polymerase chain reaction (PCR) in placenta specimens. Result(s):In 54 (50 %) of 108 samples the karyotype was normal, in 38 (35 %) samples it was abnormal and in 16 (15 %) samples karyotype was undetermined. No U. urealyticum, M. hominis, HCMV or AAV 2 DNA was detected, while C. trachomatis DNA was detected in one (1 %) and HPV DNA in eight (7 %) samples. No significant correlation of HPV positive findings with karyotype status was established. Conclusion(s):Our findings do not support a role of C. trachomatis, U. urealyticum, M. hominis, HCMV and AAV infections in miscarriages during the first trimester of pregnancy. However, further investigation should be made to determine a possible involvement of HPVs in the development of genetic abnormalities of the fetus, and in miscarriages.

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Section: Discussionmentioning

confidence: 99%

Possible role of bacterial and viral infections in miscarriages

Matovina

Husnjak

Milutin

et al. 2004

Fertility and Sterility

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“…The bacterial pathogens that are most frequently isolated in cases of chorioamnionitis include the human Ureaplasma species (Ureaplasma parvum and Ureaplasma urealyticum), Fusobacterium spp., Streptococcus spp., and, less frequently, Gardnerella spp., Mycoplasma spp., and Bacteroides spp. (1,62,120,(122)(123)(124). Other studies have identified that the sexually transmitted pathogens Chlamydia trachomatis and Neisseria gonorrhoeae, along with the uropathogen E. coli and yeast Candida spp., are also infrequently associated with chorioamnionitis (122,(125)(126)(127)(128).…”

Section: Causative Agents Of Chorioamnionitismentioning

confidence: 99%

The Human Ureaplasma Species as Causative Agents of Chorioamnionitis

et al. 2017

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SUMMARY The human Ureaplasma species are the most frequently isolated microorganisms from the amniotic fluid and placentae of women who deliver preterm and are also associated with spontaneous abortions or miscarriages, neonatal respiratory diseases, and chorioamnionitis. Despite the fact that these microorganisms have been habitually found within placentae of pregnancies with chorioamnionitis, the role of Ureaplasma species as a causative agent has not been satisfactorily explained. There is also controversy surrounding their role in disease, particularly as not all women infected with Ureaplasma spp. develop chorioamnionitis. In this review, we provide evidence that Ureaplasma spp. are associated with diseases of pregnancy and discuss recent findings which demonstrate that Ureaplasma spp. are associated with chorioamnionitis, regardless of gestational age at the time of delivery. Here, we also discuss the proposed major virulence factors of Ureaplasma spp., with a focus on the multiple-banded antigen (MBA), which may facilitate modulation/alteration of the host immune response and potentially explain why only subpopulations of infected women experience adverse pregnancy outcomes. The information presented within this review confirms that Ureaplasma spp. are not simply “innocent bystanders” in disease and highlights that these microorganisms are an often underestimated pathogen of pregnancy.

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“…is not reliably predictive of preterm labor (42), but there is an association when it is present in the amniotic fluid or placenta (43,125,163,339,342). Two recent reviews of antibiotic trials involving treatment of pregnant women who were culture positive for ureaplasmas in their vaginas concluded that there is insufficient evidence to recommend administration of antibiotics to women with ureaplasmas in the vagina to prevent preterm birth (148,229).…”

Section: Chorioamnionitis Spontaneous Abortion and Preterm Labormentioning

confidence: 99%

Mycoplasmas and Ureaplasmas as Neonatal Pathogens

Katz²,

2005

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SUMMARY The genital mycoplasmas represent a complex and unique group of microorganisms that have been associated with a wide array of infectious diseases in adults and infants. The lack of conclusive knowledge regarding the pathogenic potential of Mycoplasma and Ureaplasma spp. in many conditions is due to a general unfamiliarity of physicians and microbiology laboratories with their fastidious growth requirements, leading to difficulty in their detection; their high prevalence in healthy persons; the poor design of research studies attempting to base association with disease on the mere presence of the organisms in the lower urogenital tract; the failure to consider multifactorial aspects of diseases; and considering these genital mycoplasmas only as a last resort. The situation is now changing because of a greater appreciation of the genital mycoplasmas as perinatal pathogens and improvements in laboratory detection, particularly with regard to the development of powerful molecular nucleic acid amplification tests. This review summarizes the epidemiology of genital mycoplasmas as causes of neonatal infections and premature birth; evidence linking ureaplasmas with bronchopulmonary dysplasia; recent changes in the taxonomy of the genus Ureaplasma; the neonatal host response to mycoplasma and ureaplasma infections; advances in laboratory detection, including molecular methods; and therapeutic considerations for treatment of systemic diseases.

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Ureaplasma urealyticum Infection of the Placenta in Pregnancies That Ended Prematurely

Abstract: Ureaplasma urealyticum infection is associated with premature onset of labor and with increasing duration of time between rupture of membranes and delivery. Eradication of ureaplasmas from the urogenital tract of women and their partners, ideally before conception, should be considered.

Cited by 73 publications

References 17 publications

Possible role of bacterial and viral infections in miscarriages

Possible role of bacterial and viral infections in miscarriages

The Human Ureaplasma Species as Causative Agents of Chorioamnionitis

Mycoplasmas and Ureaplasmas as Neonatal Pathogens

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