Urease inhibitory activities of ZnBr2 and ZnI2 complexes of terpyridine derivatives: Systematic investigation of aryl substituents on urease inhibitory activities

Kharat, Ali Nemati; Bakhoda, Abolghasem; Brunò, Giuseppe; Rudbari, Hadi Amiri

doi:10.1016/j.poly.2012.07.035

Cited by 16 publications

(7 citation statements)

References 28 publications

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“…Complex 1 crystallizes in the C2/c space group of the monoclinic system and complex 2 crystallizes in the monoclinic I2/c space group. As per the reported ZnX 2 (X = Cl, Br, I) terpyridine complexes in literature, [19][20][21] Zn 2+ ion in complex 1 (or 2) is five coordinated by three N atoms from the terpyridine ligand and two chloride anions to form a distorted trigonal bipyramidal configuration, whereby atoms N1 and N3 occupy the axial positions and atoms N2, Cl1, and Cl2 lie in the equatorial plane. Investigation of the structures reveals that the Zn-N and Zn-Cl bond lengths in complexes 1 and 2 are comparable with each other.…”

Section: Crystal Structures Of Complexes 1 Andmentioning

confidence: 61%

“…All of the coordinate bond lengths are comparable with those reported in the literature. [19][20][21] In complex 1, the dihedral angles between the central pyridine motif and two outer pyridine rings are 3.68° and 11.15°, respectively. Due to steric hindrance effect, the bridged benzene ring (C16-C21) is not coplanar with the central pyridine ring, and the dihedral angle between them is 24.44°.…”

Section: Crystal Structures Of Complexes 1 Andmentioning

confidence: 99%

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Synthesis and characterization of novel coumarin-based terpyridine ligands and their Zn(II) complexes

Wang

Yue

Deng

2020

Journal of Chemical Research

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Two novel mononuclear Zn(II) complexes, [ZnL1Cl2] (1) (L1=( E)-3-(4-(2,2′:6′,2″-tripyridyl)-4′-styryl)-7-diethylaminocoumarin) and [ZnL2Cl2] (2) (L2=3-(4-(2,2′:6′,2″-tripyridyl)-4′-phenylimine)-7-diethylaminocoumarin), were obtained by the solvothermal method from ZnCl2 and coumarin-based terpyridine ligands. The complexes were characterized by spectroscopic methods and single-crystal X-ray diffraction. The Zn2+ in the complexes is coordinated by three nitrogen atoms of the terpyridine ligand and two chloride anions, forming a distorted trigonal bipyramidal environment. Moreover, the UV–Vis absorption and emission spectra of the ligands and complexes in diluted dichloromethane solutions were measured.

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Section: Crystal Structures Of Complexes 1 Andmentioning

confidence: 61%

Section: Crystal Structures Of Complexes 1 Andmentioning

confidence: 99%

Synthesis and characterization of novel coumarin-based terpyridine ligands and their Zn(II) complexes

Wang

Yue

Deng

2020

Journal of Chemical Research

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“…For the crystal structures of related Zn II thiocyanate complexes, see: Nie et al (2014); Kharat et al (2012); Eryazici et al (2008). 373 parameters H-atom parameters constrained Á max = 0.87 e Å À3 Á min = À0.72 e Å À3 Table 1 Selected bond lengths (Å ).…”

Section: Related Literaturementioning

confidence: 99%

Crystal structure of [2-({4-[2,6-bis(pyridin-2-yl)pyridin-4-yl]phenyl}(methyl)amino)ethanol-κ³N,N′,N′′]bis(thiocyanato-κN)zincN,N-dimethylformamide monosolvate

et al. 2014

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In the title compound, [Zn(NCS)2(C24H22N4O)]·C3H7NO, the ZnII cation is N,N′,N′′-chelated by one 2-({4-[2,6-bis(pyridin-2-yl)pyridin-4-yl]phenyl}(methyl)amino)ethanol ligand and coordinated by two thiocyanate anions in a distorted N5 trigonal–bipyramidal geometry. In the molecule, the three pyridine rings are approximately coplanar [maximum deviation = 0.026 (5) Å], and the mean plane of the three pyridine rings is twisted to the benzene ring with a small dihedral angle of 5.9 (2)°. In the crystal, complex molecules are linked by weak C—H⋯O hydrogen bonds into supramolecular chains propagated along [110]; π–π stacking is observed between adjacent chains [centroid–centroid distance = 3.678 (4) Å]. The dimethylformamide solvent molecules are linked with the complex chains via weak C—H⋯O hydrogen bonds.

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“…With the aim of discovering novel urease inhibitors, the research group of Kharat 116 synthesized six new mononuclear complexes of five‐coordinated Zn(II) bromide and iodide with terpyridine derivatives. The urease inhibitory activity of the complexes was carried out by using acetohydroxamic acid as a standard urease inhibitor.…”

Section: Classes Of Urease Inhibitorsmentioning

confidence: 99%

Structurally Diversified Heterocycles and Related Privileged Scaffolds as Potential Urease Inhibitors: A Brief Overview

Ibrar

Khan

Abbas

2013

Archiv der Pharmazie

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Ureases have emerged as significant virulence factors implicated in the pathogenesis of many clinical conditions such as pyelonephritis, hepatic coma, peptic ulceration, and the formation of injection-induced urinary stones and stomach cancer. They have also been identified as important targets in research both for human and animal health, as well as in agriculture. Strategies based on urease inhibition are the main treatment of diseases caused by urease-producing bacteria. So, in the present context, a diverse library of chemical structures is known to possess remarkable inhibitory activities against urease enzymes. The current review article summarizes and discusses endeavours towards the developments in the burgeoning field of urease inhibition in medicinal chemistry, with an emphasis on the insights that have been gleaned into the structural features that contribute to high and promising levels of anti-urease activity.

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Urease inhibitory activities of ZnBr2 and ZnI2 complexes of terpyridine derivatives: Systematic investigation of aryl substituents on urease inhibitory activities

Cited by 16 publications

References 28 publications

Synthesis and characterization of novel coumarin-based terpyridine ligands and their Zn(II) complexes

Synthesis and characterization of novel coumarin-based terpyridine ligands and their Zn(II) complexes

Crystal structure of [2-({4-[2,6-bis(pyridin-2-yl)pyridin-4-yl]phenyl}(methyl)amino)ethanol-κ³N,N′,N′′]bis(thiocyanato-κN)zincN,N-dimethylformamide monosolvate

Structurally Diversified Heterocycles and Related Privileged Scaffolds as Potential Urease Inhibitors: A Brief Overview

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Urease inhibitory activities of ZnBr2 and ZnI2 complexes of terpyridine derivatives: Systematic investigation of aryl substituents on urease inhibitory activities

Cited by 16 publications

References 28 publications

Synthesis and characterization of novel coumarin-based terpyridine ligands and their Zn(II) complexes

Synthesis and characterization of novel coumarin-based terpyridine ligands and their Zn(II) complexes

Crystal structure of [2-({4-[2,6-bis(pyridin-2-yl)pyridin-4-yl]phenyl}(methyl)amino)ethanol-κ3N,N′,N′′]bis(thiocyanato-κN)zincN,N-dimethylformamide monosolvate

Structurally Diversified Heterocycles and Related Privileged Scaffolds as Potential Urease Inhibitors: A Brief Overview

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Crystal structure of [2-({4-[2,6-bis(pyridin-2-yl)pyridin-4-yl]phenyl}(methyl)amino)ethanol-κ³N,N′,N′′]bis(thiocyanato-κN)zincN,N-dimethylformamide monosolvate