Uremia causes premature ageing of the T cell compartment in end-stage renal disease patients

Abstract

BackgroundEnd-stage renal disease (ESRD) patients treated with renal replacement therapy (RRT) have premature immunologically aged T cells which may underlie uremia-associated immune dysfunction. The aim of this study was to investigate whether uremia was able to induce premature ageing of the T cell compartment. For this purpose, we examined the degree of premature immunological T cell ageing by examining the T cell differentiation status, thymic output via T cell receptor excision circle (TREC) content and proliferative history via relative telomere length in ESRD patients not on RRT.ResultsCompared to healthy controls, these patients already had a lower TREC content and an increased T cell differentiation accompanied by shorter telomeres. RRT was able to enhance CD8+ T cell differentiation and to reduce CD8+ T cell telomere length in young dialysis patients. An increased differentiation status of memory CD4+ T cells was also noted in young dialysis patients.ConclusionBased on these results we can conclude that uremia already causes premature immunological ageing of the T cell system and RRT further increases immunological ageing of the CD8+ T cell compartment in particular in young ESRD patients.

Factors Related to the Development of CMV-Specific CD8+ T cell Response in CMV-Seropositive Solid Organ Transplant Candidates

“…CD57 þ CD28null CD8þ effector-memory T cells have been reported to have a high IFNg production in healthy young and middle-aged CMV-seropositive individuals (16). Dialysis (hemodialysis or peritoneal dialysis) further increases immunological aging of the CD8þ T cell compartment in younger patients (33)(34)(35). In this study, we have also observed an association between the months in dialysis (hemodialysis or peritoneal dialysis) and IFNg production by CMV-specific CD8þ T cells.…”

Type 2 Diabetes Mellitus Associated with Premature Aging

“…Betjes et al reported that younger patients (25 to 45 years old) with ESRD resembled older healthy controls (60 to 80 years old), as they had a significant loss of naive T-cells and a relative increase in memory T-cells showing progressive terminal differentiation (26). In accordance with the previous studies, Meijers et al revealed that uremia caused premature immune aging of the T-cell system in the patients group, compared to the healthy controls (27). The effects of aging on the immune system are widespread.…”

Lymphocyte depletion and subset alteration correlate to renal function in chronic kidney disease patients

“…22,23 Besides age, several researches also reported a lymphocyte fluctuation in CKD though most evidences were based on ESRD patients. 12,[24][25][26][27][28] Bunch of studies also indicated that both hemodialysis and uremic status can affect immune system and this disturbed immune system undoubtedly contributed to the infection susceptibility and CVD morbidity in these patients. [29][30][31][32] B lymphocytes have long been known as the unique cell type in humoral immunity through the production of antibodies.…”