Uremic Acquired Renal Cystic Disease

Ishikawa, Isao

doi:10.1159/000186434

Cited by 101 publications

(30 citation statements)

References 46 publications

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“…Although acquired renal cystic disease has been recently examined [3], few studies on acquired renal cystic disease in patients with predialysis end-stage renal disease have been reported. Whether or not mild renal impairment causes acquired cysts has not been determined.…”

Section: Discussionmentioning

confidence: 99%

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Incidence of Acquired Renal Cysts in Biopsy Specimens

Liu

Ishikawa

Horiguchi

2000

Nephron

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Aims: This study investigated whether or not acquired renal cysts develop in patients with mild chronic renal failure. Methods: A retrospective study was carried out using renal biopsy specimens from 720 patients. A renal cyst was defined as a tubule dilated >200 µm. Results: Renal cysts were found in 21 of 720 renal biopsy specimens. Serum creatinine of 21 patients with renal cysts was significantly higher than that of 699 patients without cysts (2.59 ± 2.64 vs. 1.09 ± 0.79 mg/dl) (p < 0.0001). Poor renal function (serum creatinine >1.6 mg/dl) reveals more cyst formation on biopsy specimens than good renal function (serum creatinine <1.5 mg/dl). Cysts were observed in 11 of 607 (1.8%) patients less than 50 years of age and in 10 of 113 (8.8%) patients over 51 years. To exclude simple cysts which are commonly observed in older subjects, 11 patients under 50 years of age were extensively examined. Mean serum creatinine was 2.98 ± 3.06 mg/dl (0.7–10.4 mg/dl). These 11 patients revealed low creatinine clearance of 47.5 ± 25.6 ml/min (5–71 ml/min). Creatinine clearances in 7 patients were 52–71 ml/min (serum creatinine 0.7–2.0 mg/ dl). One of 11 biopsy specimens with cysts was examined by immunohistochemistry on lectin. This specimen was positive for tetragonolobus lectin and negative for peanut lectin, suggesting that the epithelial cells lining the cyst were derived from proximal tubules, unlike those of simple cysts. Conclusion: These results suggest that low normal renal function such as creatinine clearances 52–71 ml/min due to nephron loss is sufficient to induce acquired cyst development in various renal diseases.

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Section: Discussionmentioning

confidence: 99%

“…Since the first description by Dunnill et al [1], acquired renal cystic disease has been an important complication of long-term dialysis [2, 3]. Acquired renal cystic disease may affect the prognosis of dialysis patients if acquired renal cystic disease is complicated by renal cell carcinoma or retroperitoneal bleeding [1, 4].…”

Section: Introductionmentioning

confidence: 99%

Incidence of Acquired Renal Cysts in Biopsy Specimens

Liu

Ishikawa

Horiguchi

2000

Nephron

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“…We know that renal cysts are present prior to hemodialysis treatment in approximately one third of all patients. The prevalence of ACKD described in hemodialysis patients lies between 35 and 79% (Ishikawa, 1991). So far the literature offers only few data to clarify whether hypertension is also a possible complication of ACKD.…”

Section: Wwwintechopencommentioning

confidence: 99%

Blood Pressure and Hemodialysis

Ekart¹,

Bevc²,

Hojs³

2011

Special Problems in Hemodialysis Patients

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“…Dear Sir, Amyloidosis and vesicoureteral reflux (VUR) are well known causes of end-stage renal disease (ESRD) [1,2] and ESRD may be complicated by acquired cystic renal dis ease (ACRD) and soft tissue calcification such as kidney, lung and heart [3,4], The coexistence of amyloidosis, VUR, ACRD and intrarenal calcification is rare but here such a patient with amyloidosis. VUR, ACRD and diffuse intrarenal calcification is presented.…”

Section: A Patient With Amyloidosis Vesicoureteral Reflux and Renal mentioning

confidence: 99%