Uremic Pruritus; Its Prevalence, Pathophysiology and Management

Aramwit, Pornanong; Supasyndh, Ouppatham

doi:10.5772/59352

Cited by 11 publications

(11 citation statements)

References 118 publications

(160 reference statements)

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“…Dry skin in hemodialysis patients can be due to the atrophy of sweat glands and dehydration of the stratum corneum layer of the skin (Aramwit & Supasyndh, 2015). Although dry skin is common in HD patients (Almutary et al, 2016), its prevalence and symptom severity were found to be low in our study.…”

Section: Discussioncontrasting

confidence: 55%

Does Adequate Hemodialysis Prevent Symptoms?: A National Cross-Sectional Survey

Özen

Cepken²,

Sousa

2020

Clin Nurs Res

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The aim of this study was to identify the relationship between dialysis adequacy and the incidence of symptoms in subjects treated with HD. This descriptive and cross-sectional study was conducted at two HD centers. The data were collected with the ‘Descriptive Characteristics Form of the Participants’ and the ‘Dialysis Symptom Index (DSI)’. The study was reported according to the STROBE Declaration. The study was completed with 120 patients. The most common symptom reported was feeling tired or decreased energy and the least common was difficulty concentrating. No statistically significant relationship was found between DSI results and the Kt/V or urea reduction rate levels used to evaluate dialysis adequacy. Dialysis-related symptoms can also be seen in patients with adequate dialysis levels. It is therefore necessary to query the symptoms experienced by the patients at regular intervals.

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Section: Discussioncontrasting

confidence: 55%

Does Adequate Hemodialysis Prevent Symptoms?: A National Cross-Sectional Survey

Özen

Cepken²,

Sousa

2020

Clin Nurs Res

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“…Dry skin, caused by sweat gland atrophy and dehydration of the stratum corneum layer, is thought to play a role in the development of UP. Dry skin has previously been suggested as a potential causative factor for UP [ 7 ]. Kiliç Akça and Taşci [ 25 ] reported that the incidence of UP in patients with dry skin is 3.9 times higher than in those without dry skin.…”

Section: Discussionmentioning

confidence: 99%

“…Although the pathophysiology of UP is not completely understood, several factors are thought to be involved in its development [ 7 ]. These predisposing risk factors include increased blood urea nitrogen (BUN), calcium, phosphorus and β 2 -microglobulin [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…Dry skin is caused by sweat gland atrophy and dehydration of the skin’s stratum corneum layer. These factors are also reported to play a role in UP development [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…Pruritus also contributes to the development of skin and soft tissue lesions and/or infections [ 10 ]. UP affects close to 90% of dialysis patients, and corresponds to increased morbidity and mortality [ 7 ]. The mortality risk of UP was found to be > 17% based on 18,000 HD patients in the International Dialysis Outcomes and Practice Patterns Study (DOPPS) [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

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Uremic pruritus and associated factors in hemodialysis patients: A multi-center study

Özen

Çınar

Askin

et al. 2018

Kidney Res Clin Pract.

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BackgroundUremic pruritus is a common and disturbing problem in hemodialysis patients. Although its pathogenesis is not completely understood, it is thought to be multifactorial. The aim of this study was to identify risk factors of uremic pruritus in hemodialysis patients.MethodsA total of 249 patients from four dialysis centers were included in this study. Data were collected using a questionnaire, the visual analogue scale, and the Hospital Anxiety and Depression Scale. We investigated whether socio-demographic and biochemical parameters were correlated to uremic pruritus.ResultsPruritus was present in 53.4% of the hemodialysis patients. The mean visual analogue scale severity was 6.47 ± 1.56. Patients with white blood cell (WBC) counts > 6.7 × 103/μL had 1.73 times (95% confidence interval [CI], 1.360–2.888; P = 0.036) more pruritus than did those with WBC counts < 6.7 × 103/μL. Patients with dry skin were 0.2 times (95% CI, 0.070–0.182; P = 0.028) more likely to suffer from very severe pruritus than were those with normal skin.ConclusionUremic pruritus remains a serious problem in dialysis patients. The WBC level and presence of dry skin are thought to be among its causes. Therefore, data regarding the possible risk factors of uremic pruritus must be followed closely in patients at risk.

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