Urethritis caused by Neisseria meningitidis serogroup C

Nebreda, Teresa; Campos, A; Merino, F.

doi:10.1111/j.1469-0691.1999.tb00101.x

Cited by 10 publications

(7 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Occasional reports of N. meningitidis urethritis, and even small clusters of N. meningitidis urethritis, in the United States date back to the 1940s [ 2 , 4 ]. Reported cases have been attributed to diverse lineages [ 31 ], many of which are commonly associated with invasive meningococcal disease.…”

Section: Discussionmentioning

confidence: 99%

Expansion of a urethritis-associated Neisseria meningitidis clade in the United States with concurrent acquisition of N. gonorrhoeae alleles

et al. 2018

View full text Add to dashboard Cite

BackgroundIncreased reports of Neisseria meningitidis urethritis in multiple U.S. cities during 2015 have been attributed to the emergence of a novel clade of nongroupable N. meningitidis within the ST-11 clonal complex, the “U.S. NmNG urethritis clade”. Genetic recombination with N. gonorrhoeae has been proposed to enable efficient sexual transmission by this clade. To understand the evolutionary origin and diversification of the U.S. NmNG urethritis clade, whole-genome phylogenetic analysis was performed to identify its members among the N. meningitidis strain collection from the Centers for Disease Control and Prevention, including 209 urogenital and rectal N. meningitidis isolates submitted by U.S. public health departments in eleven states starting in 2015.ResultsThe earliest representatives of the U.S. NmNG urethritis clade were identified from cases of invasive disease that occurred in 2013. Among 209 urogenital and rectal isolates submitted from January 2015 to September 2016, the clade accounted for 189/198 male urogenital isolates, 3/4 female urogenital isolates, and 1/7 rectal isolates. In total, members of the clade were isolated in thirteen states between 2013 and 2016, which evolved from a common ancestor that likely existed during 2011. The ancestor contained N. gonorrhoeae-like alleles in three regions of its genome, two of which may facilitate nitrite-dependent anaerobic growth during colonization of urogenital sites. Additional gonococcal-like alleles were acquired as the clade diversified. Notably, one isolate contained a sequence associated with azithromycin resistance in N. gonorrhoeae, but no other gonococcal antimicrobial resistance determinants were detected.ConclusionsInterspecies genetic recombination contributed to the early evolution and subsequent diversification of the U.S. NmNG urethritis clade. Ongoing acquisition of N. gonorrhoeae alleles by the U.S. NmNG urethritis clade may facilitate the expansion of its ecological niche while also increasing the frequency with which it causes urethritis.Electronic supplementary materialThe online version of this article (10.1186/s12864-018-4560-x) contains supplementary material, which is available to authorized users.

show abstract

Section: Discussionmentioning

confidence: 99%

Expansion of a urethritis-associated Neisseria meningitidis clade in the United States with concurrent acquisition of N. gonorrhoeae alleles

et al. 2018

View full text Add to dashboard Cite

show abstract

“…meningitidis has been isolated previously from anogenital sites and has been documented as a cause of anogenital infection in many publications (3)(4)(5)(6)(7)(8)(9)(10). The first report of genital meningococcal infection was published in 1942, when Carpenter and Charles (3) described the recovery of 7 isolates of N. meningitidis among 103 urogenital isolates of Neisseria species from patients with clinical symptoms of gonococcal infection.…”

Section: Discussionmentioning

confidence: 95%

“…been reported with increasing frequency as a presumed causative agent of urethritis and proctitis (4)(5)(6)9,10). Anal infections with N. meningitidis are reported to be more prevalent in homosexual than heterosexual men, probably as a consequence of the organism's preference for the rectal mucosa and of sexual behaviors that may be practiced more commonly in the homosexual population (5).…”

Section: Is Neisseria Meningitidis a New Cause Of Sexually Transmittementioning

confidence: 98%

“…As sexual habits change, the anatomic niches for the two species and the infections they cause may occasionally overlap (2)(3)(4)(5)(6)(7)(8)(9)(10). N. meningitidis can colonize the anogenital tract in men and women, causing urethritis, proctitis, and cervicitis (3)(4)(5)(6)(7)(8)(9)(10), whereas N. gonorrhoeae has been reported to cause meningitis and pharyngitis (2). We report two cases of anogenital infection caused by N. meningitidis: one case involves a homosexual male with proctitis, and the second case involves a patient with urethritis.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Is Neisseria meningitidis a New Cause of Sexually Transmitted Disease?

Nickmans

Beenhouwer

Vernelen

et al. 2014

Clinical Microbiology Newsletter

View full text Add to dashboard Cite

“…Neisseria meningitidis (NM) is best known for its ability to invade and cause meningitis and septicemia, although these invasive infections are rare and asymptomatic nasopharyngeal NM colonization is more common [13,14]. NM has previously been associated with single cases and small clusters of urethritis cases [15][16][17][18][19][20][21][22], but none of these earlier outbreaks were sustained.…”

Section: Introductionmentioning

confidence: 99%

Development of a SimpleProbe real-Time PCR Assay for rapid detection and identification of the US novel urethrotropic clade of Neisseria meningitidis ST-11 (US_NmUC)

et al. 2020

View full text Add to dashboard Cite

Urethritis, or inflammation of the urethra, is one of the most common reasons men seek clinical care. Sexually transmitted pathogens including Neisseria gonorrhoeae are responsible for over half of the symptomatic urethritis cases in U.S. men. Recently, clinics in Indianapolis, Columbus, Atlanta, and other U.S. cities began to note increasing numbers of men presenting with urethritis and Gram-negative intracellular diplococci in their urethral smears who test negative for N. gonorrhoeae. Many of these discordant cases, which have periodically reached highs of more than 25% of presumed gonococcal cases in some sexually transmitted infection clinics in the U.S. Midwest, are infected with strains in a novel urethrotropic clade of Neisseria meningitidis ST-11 (US_NmUC). However, no cultivation-independent tests are available for the US_NmUC strains, and prior studies relied on microbial culture and genome sequencing to identify them. Here, we describe a PCR test that can identify the US_NmUC strains and distinguish them from commensal and invasive N. meningitidis strains as well as N. gonorrhoeae. Our SimpleProbe®-based real-time PCR assay targets a conserved nucleotide substitution in a horizontally acquired region of US_N-mUC strain genomes. We applied the assay to 241 urine specimens whose microbial compositions had previously been determined by deep shotgun metagenomic sequencing. The assay detected the single US_NmUC positive case in this cohort, with no false positives. Overall, our simple and readily adaptable assay could facilitate investigation of the pathogenesis and epidemiology of the US_NmUC clade.

show abstract

Urethritis caused by Neisseria meningitidis serogroup C

Cited by 10 publications

References 11 publications

Expansion of a urethritis-associated Neisseria meningitidis clade in the United States with concurrent acquisition of N. gonorrhoeae alleles

Expansion of a urethritis-associated Neisseria meningitidis clade in the United States with concurrent acquisition of N. gonorrhoeae alleles

Is Neisseria meningitidis a New Cause of Sexually Transmitted Disease?

Development of a SimpleProbe real-Time PCR Assay for rapid detection and identification of the US novel urethrotropic clade of Neisseria meningitidis ST-11 (US_NmUC)

Contact Info

Product

Resources

About