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Fritz, Alfred Herbert; Schulze, Günter

doi:10.1007/978-3-642-12879-0_2

Cited by 4 publications

(5 citation statements)

References 3 publications

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“…76 These parameters can be used to reduce the impact of double-layer charging, thereby improve the current produced by oxidation/ reduction reaction of redox reporter, and make high signal-to-noise measurements with lower detection limits. 77 These extra functions makes pulsed voltammetric techniques better interrogation approaches for aptasensing of clinically relevant targets, which normally produce small changes in signal current as a result of charging currents. [78][79][80][81][82] Recent reports show that in vivo Kinetic Differential Measurements (KDM) of specific targets are possible with pulse techniques; [83][84][85] were the target bound receptors vs free receptors population are probed by tuning the waveform frequency and amplitude.…”

Section: Conventional Electrochemical Methods For Aptasensingmentioning

confidence: 99%

Review—Aptamer-Based Electrochemical Sensing Strategies for Breast Cancer

Sunday

Chowdhury

2021

J. Electrochem. Soc.

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The importance of developing molecular diagnostic aimed at detecting low concentrations of protein biomarkers, that are present in early stages of breast cancer cannot be over emphasised. This is driven in large part by the need to fabricate minimally- or non-invasive, portable, rapid and less expensive testing technologies. In this context, the capability of electrochemical methods combined with the customizability of aptamers to specifically bind various targets in complex biological fluids has realized significant impact. Aptamers are relatively less sensitive to temperature variations, and their small 3-dimensional nucleic acid structure supports specific binding with target molecules. Consequent upon these clinically favorable properties, different aptamer-based electrochemical sensing strategies have been fabricated over the decades, and various transducing techniques are classified based on the signals generated. Here we review the recent advances of these strategies for the next generation of breast cancer diagnostics, with emphasis on their challenges, possible solutions and diagnostic prospects.

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Section: Conventional Electrochemical Methods For Aptasensingmentioning

confidence: 99%

Review—Aptamer-Based Electrochemical Sensing Strategies for Breast Cancer

Sunday

Chowdhury

2021

J. Electrochem. Soc.

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“…The inert gas is used not only for the protection of the component and the electrode tip from atmospheric gases, but is also applied to achieve different weld seam geometries and penetration depths [22]. In this context, an important parameter is the heat conductivity of the shielding gas, which does not only affect the current density within the shielding gas during TIG, but also the resulting shape of the weld seam and the temperatures occurring in the work piece.…”

Section: Manipulation Of the Weld Pool Geometrymentioning

confidence: 99%

Laser Welding of Copper Using Multi Mode Fiber Lasers at Near Infrared Wavelength

et al. 2014

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Due to the increasing electrification of automotive drives and the expansion of decentralized renewable energy generation, the consumption of copper for the fabrication of electrical components such as electric motors or conducting paths increases. To join these components, laser welding is more frequently used since it represents a flexible and fully automatable joining process. Because of the high thermal conductivity, the low absorption coefficient for infrared wavelength of common laser beam sources and the resulting limited process efficiency, welding of copper alloys represents a major challenge for laser assisted processes. In this paper, experimental investigations are presented to identify arising process limits during laser welding of pure copper materials with multi-mode fiber lasers at near infrared wavelength depending on the applied laser power and welding velocity. In addition, a potential stabilization of the welding process by shielding gas support was examined. Further investigations were focused on the influence of shielding gas on the molten pool geometry.

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“…The resulting high-cutting temperatures lead to problems such as poor dimension accuracy [13], a high thermal strain on the workpiece surface that causes material structure changes as well as high tensile stresses [12], and a high wear rate of the grinding tool [13]. Four types of tool wear categories can occur during machining; tribochemical reactions (diffusion, oxidation), adhesion, abrasion, and crack formation [14]. Feng conducted micro grinding experiments to identify profile changes of diamond grits over the tool life cycle, by inspecting each grit at the bottom surface of MPGTs before and after machining a microchannel.…”

Section: Introductionmentioning

confidence: 99%

“…Cracks on cutting edges are usually the result of alternating loads during a cutting process that happens due to an interrupted cut. Adhesions occur for given cutting edge/workpiece pairings due to high process forces and high process temperatures [14]. Adhesions become a problem when they clog the abrasive layer of MPGTs or form buildup edges on abrasive grits.…”

Section: Introductionmentioning

confidence: 99%

“…Metalworking fluids (MWFs) have the task to dissipate heat, reduce friction, and support the transport of chips from the machining zone [17]. Using MWFs that are suitable for a given tool/workpiece pair, leads to better chip formation, lower cutting forces, better process stability, and improved surface quality for machined workpieces [14]; ultimately, they prevent or inhibit the aforementioned tool wear mechanisms.…”

Section: Introductionmentioning

confidence: 99%

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Submerged micro grinding: a metalworking fluid application study

Arrabiyeh

Heintz

Kieren-Ehses

et al. 2020

Int J Adv Manuf Technol

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Micro machining with micro pencil grinding tools (MPGTs) is an emerging technology that can be used to manufacture closed microchannel structures in hard and brittle materials as well as hardened steels like 16MnCr5. At their current operating conditions, these tools have a comparatively short tool life. In previous works, MPGTs in combination with a minimum quantity lubrication (MQL) system were used to manufacture microchannels in 16MnCr5 hardened steel. The study has shown that steel adhesions clog the abrasive layer of MPGTs, most likely resulting from insufficient lubrication. In this paper, a metalworking fluid (MWF) supply method was developed to improve the process: a submerged micro grinding process, in which machining takes place inside a pool of MWF. In this study, the effect of seven types of MWFs on material adhesions at the bottom surface of the tool is evaluated. Equivalent good MWFs are then compared in a micro pendulum grinding experiment till failure.

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Urformen

Cited by 4 publications

References 3 publications

Review—Aptamer-Based Electrochemical Sensing Strategies for Breast Cancer

Review—Aptamer-Based Electrochemical Sensing Strategies for Breast Cancer

Laser Welding of Copper Using Multi Mode Fiber Lasers at Near Infrared Wavelength

Submerged micro grinding: a metalworking fluid application study

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