Urgent needs of caregiving in ageing populations with Alzheimer’s disease and other chronic conditions: Support our loved ones

Culberson, John; Kopel, Jonathan; Sehar, Ujala; Reddy, P. Hemachandra

doi:10.1016/j.arr.2023.102001

Cited by 16 publications

(2 citation statements)

References 224 publications

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“…As populations are aging, the global numbers of people with PD are increasing, placing a heavy financial and emotional burden on individuals, families, and society at large ( 30 , 31 ). L-DOPA is currently recognized as a drug that offers good symptom control in patients with PD, but most patients will develop LID after long-term application, with mechanisms that are complex and not yet understood.…”

Section: Overview Of Lidmentioning

confidence: 99%

Levodopa-induced dyskinesia: interplay between the N-methyl-D-aspartic acid receptor and neuroinflammation

Zhang,

Liu,

Tuo

et al. 2023

Front. Immunol.

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Parkinson’s disease (PD) is a common neurodegenerative disorder of middle-aged and elderly people, clinically characterized by resting tremor, myotonia, reduced movement, and impaired postural balance. Clinically, patients with PD are often administered levodopa (L-DOPA) to improve their symptoms. However, after years of L-DOPA treatment, most patients experience complications of varying severity, including the “on-off phenomenon”, decreased efficacy, and levodopa-induced dyskinesia (LID). The development of LID can seriously affect the quality of life of patients, but its pathogenesis is unclear and effective treatments are lacking. Glutamic acid (Glu)-mediated changes in synaptic plasticity play a major role in LID. The N-methyl-D-aspartic acid receptor (NMDAR), an ionotropic glutamate receptor, is closely associated with synaptic plasticity, and neuroinflammation can modulate NMDAR activation or expression; in addition, neuroinflammation may be involved in the development of LID. However, it is not clear whether NMDA receptors are co-regulated with neuroinflammation during LID formation. Here we review how neuroinflammation mediates the development of LID through the regulation of NMDA receptors, and assess whether common anti-inflammatory drugs and NMDA receptor antagonists may be able to mitigate the development of LID through the regulation of central neuroinflammation, thereby providing a new theoretical basis for finding new therapeutic targets for LID.

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Section: Overview Of Lidmentioning

confidence: 99%

Levodopa-induced dyskinesia: interplay between the N-methyl-D-aspartic acid receptor and neuroinflammation

Zhang,

Liu,

Tuo

et al. 2023

Front. Immunol.

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“…The demand for palliative care is growing as the population ages and the prevalence of chronic illnesses rises. 3 …”

Section: Introductionmentioning

confidence: 99%

A content analysis of YouTube videos on palliative care: understanding the quality and availability of online resources

Almobarak

2024

Palliat�Care

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Background: Improvement in quality care is an important aspect of palliative care for individuals with serious illnesses. Palliative care is a multidisciplinary strategy that addresses the physical, emotional, social, and spiritual needs of patients and their families. As technology advances, digital media – especially YouTube – has come to serve as a virtual educational platform, offering resources for health-related information, including information about palliative care. Objectives: In this research, the main goal was to evaluate the quality and availability of online resources related to palliative care. Design: Two theoretical frameworks were used: the Health Communication Model and the Information Quality Framework. These frameworks offer a way to understand how YouTube videos contribute to palliative care information and assess the quality of that information. Methods: This study utilizes a quantitative analysis approach to assess the quality and accessibility of YouTube videos on palliative care. Specifically, a random sample of 300 YouTube videos addressing palliative care was examined. Descriptive statistics were used to analyze the data, including the frequency and distribution of the different types of content, sources, and quality indicators. Chi-square tests were done to compare the quality of information provided by different sources and types of content. Results: The results showed a variety of video types, with educational videos being the most common (40%), followed by personal stories (26.7%) and promotional videos (16.7%). We found that healthcare organizations (30%) and individual content creators (46.7%) were the sources for these videos. Conclusion: There were varying scores in terms of accuracy, completeness, and relevance when it came to quality assessment. While many videos received excellent ratings, some received poor ratings. Additionally, this analysis revealed that the majority of these videos were in English (83.3%), which poses a limitation for non-English speakers who may have difficulty understanding them.

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A Resource-Efficient Approach of GNSS Activation for Pedestrian Monitoring

Junior,

Díez,

Bahillo

et al. 2024

Lecture Notes of the Institute for Computer Sciences, Social Informatics and Telecommunications Engineering

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Urgent needs of caregiving in ageing populations with Alzheimer’s disease and other chronic conditions: Support our loved ones

Cited by 16 publications

References 224 publications

Levodopa-induced dyskinesia: interplay between the N-methyl-D-aspartic acid receptor and neuroinflammation

Levodopa-induced dyskinesia: interplay between the N-methyl-D-aspartic acid receptor and neuroinflammation

A content analysis of YouTube videos on palliative care: understanding the quality and availability of online resources

A Resource-Efficient Approach of GNSS Activation for Pedestrian Monitoring

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