Urgotul^®: a novel non-adherent lipidocolloid dressing

Abstract

Urgotul belongs to a new class of non-adherent dressings: the lipidocolloid dressings. It is composed of an open weave polyester mesh impregnated with hydrocolloid polymers dispersed within petrolatum. The first clinical trial data are presented. Efficacy and safety were evaluated in a multicentre non-comparative trial involving 92 patients treated to healing or up to 4 weeks. Adult outpatients with acute wounds (n = 34), leg ulcers (n = 24), other chronic wounds (n = 14) or with second-degree burns (n = 20) were included. Results showed 32.4% (n = 11) of the acute wounds, 12.5% (n = 3) of the leg ulcers and 14.3% (n = 2) of the other chronic wounds completely healed before 4 weeks. Surface areas decreased on average by 76.4%, 63.5% and 44.2% at study endpoint respectively. For burns, 19 patients healed (95%) within 5-19 days. A total of 771 dressing changes were performed during the course of the study. Dressing application was considered as easy or very easy in 90% or more of the changes and there was no difficulty in removing the dressing in about 95% of the cases. Safety was good with five reports of a transitory local adverse event, probably dressing-related, being observed, two patients (2.2%) prematurely stopped treatment because of moderate periwound erythema. Urgotul is a highly promising new dressing which is currently undergoing further comparative clinical evaluation.

A general overview of burn care

“…A large number of newer dressings have become available, most of them based on the principles of moist wound healing (116,117,(133)(134)(135)(136) which prevents the wound from desiccation and prevents gauze-type adherence and tissue ingrowth. Some modern gauzebased dressings have been shown not to be adherent (137,138) and, therefore, might be indicated as well. Most moisture retentive, non adherent dressings also help reducing pain (139).…”

A randomised, controlled, non‐inferiority trial comparing the performance of a soft silicone‐coated wound contact layer (Mepitel One) with a lipidocolloid wound contact layer (UrgoTul) in the treatment of acute wounds

“…This RCT, conducted in usual care settings by a group of GPs, is the first to compare a WCL dressing coated with a micro‐perforated soft silicone layer (Mepitel One) to a WCL dressing type impregnated with a lipidocolloid mixture (UrgoTul). Both studied WCL dressings are largely used to manage uncomplicated and slightly exudating acute wounds as well as chronic wounds at the proliferative stage of healing . The primary objective of this trial was to confirm that Mepitel One is, at worst, not inferior to UrgoTul in terms of pain induced by dressing removal in order to conclude that both dressing types can be considered therapeutically equivalent.…”

“…Both studied WCL dressings are largely used to manage uncomplicated and slightly exudating acute wounds as well as chronic wounds at the proliferative stage of healing. 5,6,8,10,24 The primary objective of this trial was to confirm that Mepitel One is, at worst, not inferior to UrgoTul in terms of pain induced by dressing removal in order to conclude that both dressing types can be considered therapeutically equivalent. However, based on the PP population, significantly fewer patients experienced pain severity ≥30 mm on VAS at first dressing removal with Mepitel One compared with UrgoTul.…”

“…The first approach involves the use of a mixture of carboxymethylcellulose (CMC) particles combined with lipidic particles. This mixture, when applied on the wound bed, forms a gel that facilitates atraumatic removal and enhances fluid management . This technology is commercially available in the form of the UrgoTul dressing, supplied by Urgo Medical.…”

“…This mixture, when applied on the wound bed, forms a gel that facilitates atraumatic removal and enhances fluid management. 5,6 This technology is commercially available in the form of the UrgoTul dressing, supplied by Urgo Medical. The second approach is based on the concept of covering a polyester or nylon mesh with a very thin micro-perforated layer of silicone, a gentle pressure-sensitive adhesive.…”