Uric acid and cardiovascular disease

Ndrepepa, Gjin

doi:10.1016/j.cca.2018.05.046

Cited by 358 publications

(282 citation statements)

References 201 publications

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“…Incidence of cardiovascular events was found to be higher in the hyperuricemic group and, particularly, in the higher tertile when the patients were divided by SUA levels. This is in agreement with many previously reported findings . Interestingly, our correlation analysis revealed that SUA level was associated with increased CVD incidence only when there was abnormal eGFR levels.…”

Section: Discussionsupporting

confidence: 93%

“…This is in agreement with many previously reported findings. 23,24 Interestingly, our correlation analysis revealed that SUA level was associated with increased CVD incidence only when there was abnormal eGFR levels. In patients with normal eGFR level, there was no relationship between SUA level and CVD incidence.…”

Section: Ta B L E 1 Clinical and Biochemical Parameters Of Patients Wmentioning

confidence: 77%

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Association between serum uric acid levels and metabolic markers in patients with type 2 diabetes from a community with high diabetes prevalence

2019

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Background The importance of uric acid has been increasingly appreciated because of its association with the development of diabetes mellitus and related diseases. Objective This study was undertaken to evaluate the association of serum uric acid (SUA) level with different clinical and biochemical parameters in patients with type 2 diabetes from Saudi Arabia. Methods Clinical and biochemical data from the patients were obtained and assessed in a cross‐sectional design. Relationships between SUA level and various clinical and biochemical parameters were analysed. Results SUA level was positively associated with increased incidence of cardiovascular diseases (CVD) in patients with abnormal eGFR (<90 mL/min/1.73 m2). HbA1c was found to be inversely associated with hyperuricemia in patients with normal eGFR level (≥90 mL/min/1.73 m2). Incidence of metabolic syndrome did not show any relationship with SUA level. However, the incidence of hypertension, a component of metabolic syndrome, was significantly higher among patients with hyperuricemia. Waist circumference and serum triglycerides were higher, whereas serum high‐density lipoprotein level was lower in patients with higher SUA level. Patients with hyperuricemia had higher incidence of CVDs than those of the normouricemic group. Conclusion SUA level was positively associated with incidence of cardiovascular diseases CVD in patients with abnormal eGFR. HbA1c correlated significantly with SUA level in patients with normal eGFR. Incidence of metabolic syndrome did not show any association with SUA level. Incidence of hypertension, waist circumference and serum triglycerides were significantly higher and serum high‐density lipoprotein level was lower in patients with higher SUA level.

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Section: Discussionsupporting

confidence: 93%

Section: Ta B L E 1 Clinical and Biochemical Parameters Of Patients Wmentioning

confidence: 77%

Association between serum uric acid levels and metabolic markers in patients with type 2 diabetes from a community with high diabetes prevalence

2019

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“…This is because the protease yielded by SCFP was higher than AOFP and protease improved the protein utilization of the host, thereby decreasing the UA content in the blood. UA is a metabolite of protein that has an antioxidant function but is converted to a pro-oxidant in the cell or cytoplasm, and may be associated with cardiovascular disease when the concentration increases [25]. In addition, UA also promotes inflammation and is associated with insulin resistance and metabolic disorders [25].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Combined Use of Saccharomyces Cerevisiae and Aspergillus Oryzae with Phytase Fermentation Products on Growth, Inflammatory, and Intestinal Morphology in Broilers

Chuang

Lin

Hsieh

et al. 2019

Animals

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Simple Summary: The stress and anti-nutrient effect caused by environmental problems and animal feed is an urgent problem in poultry production. As ancient probiotics, Aspergillus oryzae and Saccharomyces cerevisiae can effectively improve the immunity of animals. Furthermore, the anti-nutrient object, phytate, reduces nutrition absorption. Therefore, S. cerevisiae or A. oryzae with phytase co-fermentation may help solve these problems. Results show that the addition of a fermentation product can effectively reduce the inflammatory response and drop the number of harmful bacteria in the ileum of broilers. Among them, A. oryzae fermentation product has a better effect than S. cerevisiae fermentation product.Abstract: Saccharomyces cerevisiae and Aspergillus oryzae are both ancient probiotic species traditionally used as microbes for brewing beer and soy sauce, respectively. This study investigated the effect of adding these two probiotics with phytase fermentation products to the broilers diet. Fermented products possess protease and cellulase, and the activities were 777.1 and 189.5 U/g dry matter (DM) on S. cerevisiae fermented products (SCFP) and 190 and 213.4 U/g DM on A. oryzae fermented products (AOFP), respectively. Liposaccharides stimulated PBMCs to produce nitric oxide to 120 µmol. Both SCFP and AOFP reduced lipopolysaccharides stimulated peripheral blood mononuclear cells (PBMCs) nitric oxide release to 40 and 60 µmol, respectively. Nevertheless, in an MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay, SCFP and AOFP also increased the survival rate of lipopolysaccharides stimulated PBMCs by almost two-fold compared to the negative control. A total of 240 broilers were divided into four groups as Control, SCFP 0.1% (SCFP), SCFP 0.05% + AOFP 0.05% (SAFP), and AOFP 0.1% (AOFP) groups, respectively. Each group had 20 broilers, and three replicate pens. The results showed that the addition of SCFP, SAFP, and AOFP groups did not affect the growth performances, but increased the jejunum value of villus height and villus: crypt ratio on SAFP and AOFP groups compared to the control and SCFP groups. Furthermore, adding SCFP, SAFP, and AOFP significantly reduced the number of Clostridium perfringens in ileum chyme. SCFP, SAFP, and AOFP significantly reduced the amount of interleukin-1β, inducible nitric oxide synthases, interferon-γ, and nuclear factor kappa B mRNA expression in PBMCs, especially in the AOFP group. In summary, all the SCFP, SAFP, and AOFP groups can be suggested as a functional feed additive since they enhanced villus: crypt ratio and decreased inflammation-related mRNA expression, especially for AOFP group in broilers.

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“…The persistently high level of serum uric acid can cause several adverse health consequences such as gout, nephrolithiasis and urate nephropathy. It is also closely associated with metabolic syndrome and cardiovascular diseases via the interaction with its associated conditions, such as insulin resistance, hypertension, dyslipidemia and central obesity . The prevalence of hyperuricemia varies in regions of the world, and is as high as 18% in some populations…”

Section: Introductionmentioning

confidence: 99%

“…It is also closely associated with metabolic syndrome and cardiovascular diseases via the interaction with its associated conditions, such as insulin resistance, hypertension, dyslipidemia and central obesity. 5,6 The prevalence of hyperuricemia varies in regions of the world, and is as high as 18% in some populations. 7 Several epidemiological studies have suggested the relationship between PHPT and hyperuricemia although the results were not consistent across all studies.…”

Section: Introductionmentioning

confidence: 99%

Primary hyperparathyroidism is associated with a higher level of serum uric acid: A systematic review and meta‐analysis

2019

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Objectives Studies have suggested that primary hyperparathyroidism could be a risk factor for hyperuricemia although the results were not consistent across the studies. This systematic review and meta‐analysis was performed in order to identify all available studies and summarize their results together. Methods A systematic review was performed using EMBASE and MEDLINE from inception to August 2018 to identify all cohort studies that consisted of 2 cohorts, a cohort of patients with primary hyperparathyroidism and a cohort of individuals without hyperparathyroidism. Eligible studies had to provide data on mean serum uric acid level and standard deviation of both cohorts, which would be extracted to calculate mean difference (MD). Pooled MD was then calculated by combining MDs of each study using a random‐effects model. Funnel plot was used for evaluation for publication bias. Results A total of 9 cohort studies met the inclusion criteria and were included into the meta‐analysis. The pooled analysis found that patients with primary hyperparathyroidism had a significantly higher level of serum uric acid than individuals without hyperparathyroidism with the pooled MD of 65.00 μmol/L (95% CI 37.74‐92.25). The statistical heterogeneity was high with I2 of 90%. The funnel plot was relatively symmetric and did not provide evidence for publication bias. Conclusion Patients with primary hyperparathyroidism had a significantly higher level of serum uric acid compared to individuals without hyperparathyroidism.

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Uric acid and cardiovascular disease

Cited by 358 publications

References 201 publications

Association between serum uric acid levels and metabolic markers in patients with type 2 diabetes from a community with high diabetes prevalence

Association between serum uric acid levels and metabolic markers in patients with type 2 diabetes from a community with high diabetes prevalence

Evaluation of the Combined Use of Saccharomyces Cerevisiae and Aspergillus Oryzae with Phytase Fermentation Products on Growth, Inflammatory, and Intestinal Morphology in Broilers

Primary hyperparathyroidism is associated with a higher level of serum uric acid: A systematic review and meta‐analysis

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