Uric Acid and NT-proBNP as Biomarkers of Cardiovascular Dysfunction in Hyperthyroidism and Hypothyroidism

Cozma, Laurette; Szalontay, Andreea Silvana; Cozma, Sebastian; Dascălu, Cristina Gena; Cojocaru, Doina-Clementina; Mitu, Florin; Bitere, Oana; Ghiciuc, Cristina Mihaela

doi:10.37358/rc.17.12.6016

Rev. Chim.

2018

DOI: 10.37358/rc.17.12.6016

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Uric Acid and NT-proBNP as Biomarkers of Cardiovascular Dysfunction in Hyperthyroidism and Hypothyroidism

Laurette Cozma¹,

Andreea Silvana Szalontay²,

Sebastian Cozma³

et al.

Abstract: The various thyroid axis dysfunctions have cardiovascular consequences both in hyperthyroidism and in hypothyroidism. This cross-sectional study included hyperthyroid and hypothyroid female patients in whom uric acid and NT-proBNP were determined in relation to changes in clinical findings and some echocardiographic parameters. The results of our study suggest that NT-proBNP is a better predictor than uric acid, correlating with left ventricular diastolic dysfunction and systolic blood pressure variations.

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2023

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Effect of thyroid dysfunction on N-terminal pro-B-type natriuretic peptide levels: A systematic review and meta-analysis

Zhang

et al. 2023

Front. Endocrinol.

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PurposeThyroid hormones (THs) significantly affect the cardiovascular system. N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a useful biomarker for diagnosing, evaluating, and predicting outcomes in heart failure (HF). This comprehensive review and meta-analysis aimed to investigate the effects of thyroid dysfunction (hypothyroidism and hyperthyroidism) on NT-proBNP levels.MethodsTwo investigators independently searched PubMed, Embase, Cochrane Library, and Web of Science databases for studies published from inception to July 31, 2022, without any restrictions on language.Results21 studies were included. In participants without HF, NT-proBNP levels may be elevated in those with overt hyperthyroidism (standardized mean difference [SMD] 2.38, 95% confidence interval [CI]:1.0-3.76). Notably, among patients with preexisting HF, significantly higher NT-proBNP levels were found in patients with overt hyperthyroidism, overt hypothyroidism, or subclinical hypothyroidism than in euthyroid subjects (SMD [95%CI] = 0.31[0.01, 0.62], 0.32[0.08, 0.56], and 0.33[0.21, 0.46], respectively). Seven trials compared NT-proBNP levels in patients with thyroid dysfunction before and after therapy, and significant drops in NT-proBNP levels were observed in patients with hyperthyroidism (SMD [95%CI] = -1.53[-2.50, -0.55]) upon achieving a euthyroid state. In contrast, increased NT-proBNP levels were observed in hypothyroid patients after treatment (SMD [95%CI] = 1.07[0.28, 1.85]).ConclusionThyroid dysfunction can significantly affect NT-proBNP levels, which may change upon achieving a euthyroid state. Notably, the effect of thyroid dysfunction on cardiac function may depend on the underlying cardiac status. Thus, timely recognition and effective treatment of cardiac symptoms in patients with thyroid dysfunction are mandatory because the prognosis of HF may be improved with appropriate treatment of thyroid dysfunction.Systematic review registrationhttps://www.crd.york.ac.uk/prospero, identifier CRD42022353700.

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Effect of thyroid dysfunction on N-terminal pro-B-type natriuretic peptide levels: A systematic review and meta-analysis

Zhang

et al. 2023

Front. Endocrinol.

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Uric Acid and NT-proBNP as Biomarkers of Cardiovascular Dysfunction in Hyperthyroidism and Hypothyroidism

Cited by 1 publication

References 15 publications

Effect of thyroid dysfunction on N-terminal pro-B-type natriuretic peptide levels: A systematic review and meta-analysis

Effect of thyroid dysfunction on N-terminal pro-B-type natriuretic peptide levels: A systematic review and meta-analysis

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