Uric acid clearance in patients with gout and normal subjects.

Snaith, M L; Scott, J. T.

doi:10.1136/ard.30.3.285

Cited by 31 publications

(7 citation statements)

References 10 publications

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“…Overall, clearance of urate is impaired in patients with gout compared with normal people. In a series of cases in this country a mean urate clearance of 5-8 ml/min was found in normal subjects compared with 3-6 ml/min in gout patients (Snaith and Scott, 1971). To these quantitative variations in genetically determined metabolic and renal functions, the precise nature of which has yet to be elucidated, are added in many cases the effects of external agents, particularly food (with regard to both its purine and energy content), drugs (for example, diuretics), and alcoholic liquors.…”

Section: Primary and Secondary Goutmentioning

confidence: 87%

New knowledge of the pathogenesis of gout

Scott¹

1978

J Clin Pathol

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The clinical features of gout have been well-recognised since ancient times. Knowledge of its underlying metabolic causes began towards the end of the eighteenth century with the discovery of uric acid in urinary calculi and gouty tophi, and during the nineteenth century Sir Alfred Garrod showed that the blood of gouty subjects contained an excess of uric acid which became deposited in crystalline form in the joints. The later work of Emil Fischer, establishing that uric acid was a purine compound and thus potentially related to the nucleic acid constituents adenine and guanine, and the improved methodology of uric acid determination by Folin and Dennis completed this part of the story.Other developments during the twentieth century have included, firstly, the realisation that hyperuricaemia and gout have many different causes; secondly, a swift advance, gained by biochemical, isotope, and cell-culture techniques, in our knowledge of purine metabolism, including the discovery by Seegmiller and his colleagues in 1967 of the first specific enzymatic defect (HGPRT deficiency) responsible for one special type of gout; and, thirdly, from the therapeutic aspect, a remarkable facility to control both the acute gouty attack and the level of uric acid in the blood.People who develop gout have usually lived for many years, unknown to themselves, with a raised

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Section: Primary and Secondary Goutmentioning

confidence: 87%

New knowledge of the pathogenesis of gout

Scott¹

1978

J Clin Pathol

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“…Independent of age, normal values are above 0.8 mmoL/L in healthy subjects[ 28 ]. The normal value of FEUA is approximately 8%; values above 10% are considered to reflect a reabsorption defect[ 29 ]. Consequently, using as a reference the normal values as defined in healthy populations, the observation that nearly 30% of the naïve HBV-monoinfected population met the definition of SPT implies a link between SPT and HBV infection.…”

Section: Discussionmentioning

confidence: 99%

Subclinical proximal tubulopathy in hepatitis B: The roles of nucleot(s)ide analogue treatment and the hepatitis B virus

Brayette¹,

Essig²,

Carrier³

et al. 2020

WJH

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“…) Accepted for publication March 24, 1972. Based on a paper given to the Heberden Society on March 19, 1971 in gout patients than in control subjects (Snaith and Scott, 1971), but it was found that the gout patients as a group were heavier (and taller) than the controls (Table I). Both groups were classified with relation to body weight, also for the presence or absence of other factors, namely smoking, social class, and blood group.…”

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confidence: 99%

Plasma lipid levels in gout.

Darlington¹,

Scott²

1972

Annals of the Rheumatic Diseases

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A number of investigations have previously been carried out to examine inter-relationships between hypercuricaemia, gout, and levels of plasma lipids, usually with particular reference to glycerides and cholesterol. The present study was designed to compare the levels not only of glycerides and cholesterol, but also of phospholipids and free fatty acids, in gout patients with those in a group of very closely matched control subjects; and to determine, in the gout patients, whether there was any relationship between levels of these lipid fractions and the endogenous production of uric acid as measured by urinary levels of uric acid on a low-purine diet.Plan of study 27 British patients with primary gout (25 men and 2 women) participated in the study. Some of them were on urate-lowering treatment (allopurinol or uricosuric agents) at the time when blood was taken for lipid estimations, but plasma and urinary levels of uric acid had been estimated on a low-purine diet before treatment was started.A control group of 27 subjects was taken from hospital patients suffering from a wide variety of medical and surgical conditions. None had gout or hyperuricaemia; all were of reasonable social orientation, all were taking normal diets and none was grossly obese. Initial investigations in all subjects, gout and control, excluded predisposing causes for hyperlipidaemia. The control group was matched with gout patients for age, sex, blood pressure, alcohol intake, and the presence of ischaemic vascular disease. The two groups were also matched for ponderal index 13igh (in.) which tends to be lower \VYweight (lb.)

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Uric acid clearance in patients with gout and normal subjects.

Cited by 31 publications

References 10 publications

New knowledge of the pathogenesis of gout

New knowledge of the pathogenesis of gout

Subclinical proximal tubulopathy in hepatitis B: The roles of nucleot(s)ide analogue treatment and the hepatitis B virus

Plasma lipid levels in gout.

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