Uric Acid-to-Albumin Ratio: A Novel Marker for the Extent of Coronary Artery Disease in Patients with Non-ST-Elevated Myocardial Infarction

Çakmak, Ender Özgün; Bayam, Emrah; Çelık, Mehmet; Kahyaoğlu, Muzaffer; Eren, Kıvanç; Imanov, Elmin; Karagöz, Ali; İzgi, İbrahim Akın

doi:10.1159/000514533

Cited by 22 publications

(45 citation statements)

References 35 publications

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“…In a study evaluating UAR in non-STEMI patients and including 402 patients, the UAR value was associated with a high SYNTAX score and the prevalence of CAD. 13 In our study, the UAR was an important predictor of mortality in STEMI patients and increased UAR values were directly proportional to the risk of mortality when evaluated both continuously and categorically (Figures 2 and 3). The risk prediction of UAR for mortality risk in STEMI patients can be explained by the relationship of high UA with inflammatory process/oxidative risk and low SA with increased inflammation and catabolic process.…”

Section: Discussionsupporting

confidence: 50%

Section: Introductionmentioning

confidence: 99%

“…12 The uric acid/albumin ratio (UAR), which includes both of the mentioned parameters, may be related to the increased risk of mortality in patients with ACS, and also, a study showed that high UAR values were associated with an increased SYNTAX score. 13 Early risk stratification and evaluation of mortality markers in STEMI patients are critical in determining patient follow-up and treatment strategies. It has been shown that STEMI-related mortality can be high even without established correctable risk factors HT, diabetes mellitus (DM) hyperlipidemia (HL), or smoking.…”

Section: Introductionmentioning

confidence: 99%

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A New Predictor of Mortality in ST-Elevation Myocardial Infarction: The Uric Acid Albumin Ratio

et al. 2022

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Several studies have shown that high uric acid (UA) and low serum albumin (SA) values increase the risk of cardiovascular disease and mortality in ST-elevation myocardial infarction (STEMI). We determined whether the uric acid/albumin ratio (UAR) is a predictor of mortality in STEMI patients. All patients who presented at our center with a diagnosis of STEMI and underwent percutaneous intervention from 2015 to 2020 were screened consecutively; 4599 patients were included. A Cox proportional hazards model was used to evaluate UAR, and adjusted predictors obtained from laboratory findings and clinical characteristics contributed to mortality. Also, a regression model was presented with a directed acyclic graph (DAG). The median age of the patients was 58 years (IQR [interquartile range]: 50–67); 3581 patients (77.9%) were male. The incidence of mortality in the entire patient group was 11.9%. Median follow-up duration of all groups was 42 months. Multivariate Cox proportional regression (model-1) analysis showed age (increase 50 to 67 years; HR [hazard ratio]: 1.34, 95% CI 1.18–1.52) and UAR (increase 1.15–1.73; HR: 1.33, 95% CI 1.16–1.52) were associated with mortality. UAR may be a prognostic factor for mortality in STEMI patients and an easily accessible parameter to identify high-risk patients.

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Section: Discussionsupporting

confidence: 50%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A New Predictor of Mortality in ST-Elevation Myocardial Infarction: The Uric Acid Albumin Ratio

et al. 2022

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“…Çakmak reported that UAR was an independent predictor of the severity of coronary artery disease but did not assess type A AAD speci cally [14]. In this study, we focused on patients diagnosed with type A AAD and treated with surgery.…”

Section: Discussionmentioning

confidence: 99%

“…Heng Gao (  gaoheng19820109@163.com ) Shaanxi Provincial People's Hospital cerebrovascular disease and other cardiovascular diseases [11][12][13].Çakmak reported that the uric acid-toalbumin ratio (UAR) is a novel in ammatory marker that independently provides better predictive ability for outcomes than the C-reactive protein-to-albumin ratio; thus, UAR might be useful for predicting the extent of in on-ST-elevation myocardial infarction NSTEMI patients [14]. However, no studies have been conducted on the effect of UAR on the prognosis of patients with type A AAD, and whether the predictive value of UAR for prognosis differs from SA level or uric acid level.…”

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confidence: 99%

Preoperative Uric Acid-to-albumin Ratio as a New Indicator for Predicting Long-term Prognosis in Patients With Acute Type a Aortic Dissection

Deng

Guo

Liu

et al. 2022

Preprint

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Objectives— We aimed to analyze the ability of the preoperative uric acid-to-albumin ratio (UAR) to predict the postoperative long-term mortality of patients with type A AAD.Methods —A total of 289 patients with type A AAD who were enrolled in this study. First, all patients were divided into two groups: UAR < 9.875 and UAR ≥ 9.875. Furthermore, according to whether death occurred after one year after surgery, the patients were divided into the non-survival and survival groups. Univariable and multivariable COX regression analyses were conducted to identify the independent risk factors for long-term death in patients with type A AAD. Receiver operating characteristic (ROC) curves were constructed to assess the values of these indices in predicting postoperative mortality. Results— Age, hypertension, albumin content, UAR, and D-dimer content were found to be independent risk factors for mortality. The area under the ROC curve (AUC) of UAR was 0.618(HR 1.904, 95% CI, 1.097 to 3.305; P< 0.05), the combination of UAR, age and D-dimer was best for predicting deaths,the area under the AUC of them was 0.751 [HR 1.904,95% CI,0.681 to 0.821; P< 0.05)].Conclusions—In patients with type A AAD, UAR may considered as a new independent risk factor for long-term mortality. a combination of UAR, age, and D-dimer content was a best predictor of deaths.

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Elevated uric acid/albumin ratio as a predictor of poor coronary collateral circulation development in patients with non‐ST segment elevation myocardial infarction

Yin,

Ye,

You

et al. 2024

Clinical Cardiology

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BackgroundUric acid/albumin ratio (UAR) is a novel composite biomarker with superior predictive value for cardiovascular disease.ObjectiveTo investigate the relationship between UAR and coronary collateral circulation (CCC) in patients with non‐ST segment elevation myocardial infarction (NSTEMI).MethodsA total of 205 NSTEMI patients who underwent coronary arteriography with at least one major coronary stenosis, 95% were included. Patients were divided into two groups according to CCC development: poorly‐developed CCC group (Rentrop 0–1) and well‐developed CCC (Rentrop 2–3). Univariate analysis and logistic regression analysis were utilized to investigate the factors influencing adverse CCC formation in NSTEMI patients. The receiver operating characteristic (ROC) curve was plotted to evaluate the predictive value of UAR, C‐reactive protein (CRP), uric acid, and albumin for patients with poorly developed CCC, and the area under the curve (AUC) was compared.ResultsThe UAR values of NSTEMI patients were significantly higher in the poorly developed CCC group than those in the well‐developed CCC group (10.19 [8.80–11.74] vs. 7.79 [6.28–9.55], p < .001). In the multiple logistic regression tests, UAR (odds ratio [OR]: 1.365, 95% confidence interval [CI]: 1.195–1.560, p < .001), CRP (OR: 1.149, 95% CI: 1.072–1.231, p < .001), and diabetes (OR: 2.924, 95% CI: 1.444–5.920, p = .003) were independent predictors of poorly developed CCC. The ROC curve analysis showed that the optimal cut‐off value of UAR was 8.78 in predicting poorly developed CCC with a sensitivity of 76.8% and specificity of 62.4%, with the AUC of 0.737 (95% Cl: 0.668–0.805, p < .001).ConclusionElevated UAR may be an independent and effective biomarker for predicting poorly‐developed CCC development in NSTEMI patients.

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Uric Acid-to-Albumin Ratio: A Novel Marker for the Extent of Coronary Artery Disease in Patients with Non-ST-Elevated Myocardial Infarction

Cited by 22 publications

References 35 publications

A New Predictor of Mortality in ST-Elevation Myocardial Infarction: The Uric Acid Albumin Ratio

A New Predictor of Mortality in ST-Elevation Myocardial Infarction: The Uric Acid Albumin Ratio

Preoperative Uric Acid-to-albumin Ratio as a New Indicator for Predicting Long-term Prognosis in Patients With Acute Type a Aortic Dissection

Elevated uric acid/albumin ratio as a predictor of poor coronary collateral circulation development in patients with non‐ST segment elevation myocardial infarction

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