2015
DOI: 10.1111/trf.13211
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Uric acid variation among regular blood donors is indicative of red blood cell susceptibility to storage lesion markers: A new hypothesis tested

Abstract: UA exhibits a storability biomarker potential. Intrinsic variability in plasma UA levels might be related to the interdonor variability observed in the storage capacity of RBCs. A model for the antioxidant effect of UA during the RBC storage is currently proposed.

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Cited by 48 publications
(64 citation statements)
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“…Recent studies have suggested that UA and the purine salvage metabolic pathway play a role in the progression of the RBC storage lesion . In support of these findings, our results underline the importance of donor‐related serum UA levels in respect to the antioxidant activity of RBCs and highlight the probable role of UA in the performance of RBCs under storage in nonleukoreduced CPDA‐1 units.…”
Section: Discussionsupporting
confidence: 87%
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“…Recent studies have suggested that UA and the purine salvage metabolic pathway play a role in the progression of the RBC storage lesion . In support of these findings, our results underline the importance of donor‐related serum UA levels in respect to the antioxidant activity of RBCs and highlight the probable role of UA in the performance of RBCs under storage in nonleukoreduced CPDA‐1 units.…”
Section: Discussionsupporting
confidence: 87%
“…Moreover, the UA‐AC levels of each unit at every time point of the storage period were strongly correlated with the values at any previous storage time, highlighting the universality of variation in UA‐AC in RBCs. Finally, previous works on different storage systems, along with works on young female donors (manuscript in preparation), who exhibit lower absolute extracellular antioxidant capacity compared to young male donors, also suggested that the storage profile, at least in terms of UA‐AC, clearly follows the interdonor differences in the prestorage levels. Consequently, along with other antioxidant variables, such as GSH and RBC physiologic properties, such as the osmotic fragility, this study suggests that UA‐AC can be safely considered a donor‐associated and in vivo measurable feature with the potential to reveal qualitative characteristics of the stored RBC units.…”
Section: Discussionmentioning
confidence: 74%
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