Uric acid versus metabolic syndrome as markers of fatty liver disease in young people with overweight/obesity

Bonito, Procolo Di; Valerio, Giuliana; Licenziati, Maria Rosaria; Sessa, Anna Di; Giudice, Emanuele Miraglia del; Morandi, Anita; Maffeis, Claudio; Baroni, Marco Giorgio; Chiesa, Claudio; Pacifico, Lucia; Manco, Melania

doi:10.1002/dmrr.3559

Cited by 16 publications

(6 citation statements)

References 45 publications

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“…Again, obese children with MetS were found to have significantly higher urinary BPA levels than obese children without MetS and in both obese groups levels were higher than in healthy controls [ 66 ]. Bisphenols may also affect uric acid metabolism, and this aspect is of concern, as a potential relationship between hyperuricemia and hypertension, MetS, fatty liver disease, and cardiovascular disease in pediatric populations has been identified [ 67 , 68 , 69 ]. The associations between BPA, bisphenol S (BPS), and bisphenol F (BPF) exposure and serum uric acid concentrations were evaluated in the Environment and Development of Children cohort study, encompassing 489 six-year-old Korean children.…”

Section: Resultsmentioning

confidence: 99%

Skeptical Look at the Clinical Implication of Metabolic Syndrome in Childhood Obesity

et al. 2023

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Metabolic syndrome (MetS) is defined by a cluster of several cardio-metabolic risk factors, specifically visceral obesity, hypertension, dyslipidemia, and impaired glucose metabolism, which together increase risks of developing future cardiovascular disease (CVD) and type 2 diabetes mellitus (T2D). This article is a narrative review of the literature and a summary of the main observations, conclusions, and perspectives raised in the literature and the study projects of the Working Group of Childhood Obesity (WGChO) of the Italian Society of Paediatric Endocrinology and Diabetology (ISPED) on MetS in childhood obesity. Although there is an agreement on the distinctive features of MetS, no international diagnostic criteria in a pediatric population exist. Moreover, to date, the prevalence of MetS in childhood is not certain and thus the true value of diagnosis of MetS in youth as well as its clinical implications, is unclear. The aim of this narrative review is to summarize the pathogenesis and current role of MetS in children and adolescents with particular reference to applicability in clinical practice in childhood obesity.

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Section: Resultsmentioning

confidence: 99%

Skeptical Look at the Clinical Implication of Metabolic Syndrome in Childhood Obesity

et al. 2023

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“…Civantos Modino S (29) discovered that overweight and obese children had higher average SUA levels, and this group had a higher probability of having metabolic syndrome. It is worth mentioning that SUA, as a marker for predicting fatty liver risk in adolescents, is more discriminative than metabolic syndrome (30) In a retrospective study, the risk of dyslipidemia increased by 27% for each 1-SD increase in SUA in children with adenoid or tonsil hypertrophy. There was a signi cant positive association between SUA and HTG (31)…”

Section: Discussionmentioning

confidence: 96%

Association of serum uric acid with hypertriglyceridemia in children and adolescents: a cross-sectional study

Si,

Chen,

Zhang

2023

Preprint

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Background: Uric acid (UA), a liver-derived metabolite, is intimately tied to metabolic disorders. Although ample research underscores its connection with hypertriglyceridemia (HTG), studies focusing on adolescents remain limited. This investigation delves into the correlation between uric acid levels and HTG among American adolescents. Methods: This cross-sectional study utilized data on 4,435 adolescents from the NHANES database spanning 2011 to 2020. The exposure variable was serum uric acid (SUA), the outcome variable was HTG, and the covariates encompassed demographics, questionnaire, physical examination and laboratory indicators. We utilized weighted logistic regression and meticulous subgroup evaluations to discern the intrinsic link between SUA and HTG. Stratified analyses augmented the validation of this association, while smooth curve fitting probed for potential non-linear correlations. Results: The study included 4,435 participants. Male adolescents might exhibit elevated SUA levels. After adjusting for all variables, the weighted multiple logistic regression model revealed that SUA had a positive correlation with HTG risk. This relationship was consistent across tertiles. Stratified analyses confirmed that the positive correlation between SUA and HTG risk was significant, irrespective of sex, age and race. Conclusions: In American children and adolescents aged 12 to 18 years, there's a pronounced affiliation between SUA and HTG. SUA could serve as a risk indicator for HTG. Regular monitoring of serum triglycerides is recommended to prevent HTG during childhood.

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“…Civantos Modino S [ 39 ] reported that overweight and obese children exhibited elevated average SUA levels, which significantly increased their likelihood of developing metabolic syndrome. Notably, SUA serves as a superior marker for predicting fatty liver risk in adolescents compared to metabolic syndrome itself [ 40 ]. In a retrospective analysis of 4,922 children diagnosed with adenoid or tonsil hypertrophy, a one standard deviation increase in serum uric acid (SUA) was associated with a 27% increased risk of dyslipidemia, with an OR of 1.270 and a 95% CI ranging from 1.185 to 1.361.…”

Section: Discussionmentioning

confidence: 99%

Association of serum uric acid with hypertriglyceridemia in children and adolescents: a cross-sectional study

Si,

Chen,

Zhang

2024

Lipids Health Dis

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Background Uric acid (UA), a liver-derived metabolite, is intimately tied to metabolic disorders. Although ample research underscores its connection with hypertriglyceridemia (HTG), studies focusing on adolescents remain limited. To fill the gaps in epidemiology,this study focused on analyzing the relationship between the levels of uric acid and HTG in a demographic sample comprising adolescents from the United States. Methods In this study, a total of 4,435 participants through the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2020. The exposure variable was serum uric acid (SUA), the effect variable was HTG, and the covariates included demographic, questionnaire, physical examination and laboratory indicators. We utilized weighted logistic regression and meticulous subgroup evaluations to discern the intrinsic link between SUA and HTG. Stratified analyses augmented the validation of this association, while smooth curve fitting probed for potential nonlinear correlations. Results The study included 4,435 participants. Male adolescents exhibit elevated SUA levels. After adjusting for all variables, the weighted multiple logistic regression model revealed that SUA was positively correlated with HTG risk (OR = 1.006, 95% CI: 1.005–1.007). This relationship was consistent across the three tertiles group of SUA (T1: OR = 1.006 [95% CI: 1.005–1.007]; T2: OR = 1.006 [95% CI: 1.005–1.007]; T3: OR = 1.004 [95% CI: 1.003–1.006]; P for trend < 0.001). Stratified analyses confirmed that the positive correlation between SUA and HTG risk was significant, irrespective of sex, age or race. Conclusions In American children and adolescents aged 12 to 18 years, there was a pronounced association between SUA and HTG. SUA could serve as a risk indicator for HTG. It is recommended that children diagnosed with HTG should be regularly tested for SUA levels. In addition, it is recommended that SUA be included in the comprehensive care of children diagnosed with HTG.

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Uric acid versus metabolic syndrome as markers of fatty liver disease in young people with overweight/obesity

Cited by 16 publications

References 45 publications

Skeptical Look at the Clinical Implication of Metabolic Syndrome in Childhood Obesity

Skeptical Look at the Clinical Implication of Metabolic Syndrome in Childhood Obesity

Association of serum uric acid with hypertriglyceridemia in children and adolescents: a cross-sectional study

Association of serum uric acid with hypertriglyceridemia in children and adolescents: a cross-sectional study

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