Uricaemia and left ventricular mass in hypertensive patients

Catena, Cristiana; Colussi, GianLuca; Capobianco, Frine; Brosolo, Gabriele; Sechi, Leonardo A.

doi:10.1111/eci.12331

Cited by 23 publications

(15 citation statements)

References 39 publications

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“…Signi cantly higher uric acid levels were found in hypertensives with LVH when compared to hypertensives without LVH. This is in agreement with previous studies which have shown that hypertensives with LVH have higher uric acid levels [86][87][88][89][90]. A large prospective population-based study in Italy found that hyperuricemia is a predictor of LVH [91].…”

Section: Discussionsupporting

confidence: 92%

Association between insulin resistance and left ventricular hypertrophy in sub-saharan hypertensive black patients with preserved ejection fraction: A case control study

Phanzu

Aliocha

Eleuthère

et al. 2020

Preprint

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Background:Conflicting information exists regarding the association between insulin resistance (IR) and left ventricular hypertrophy (LVH).We described the associations between parameters of obesity, fasting insulinemia, HOMAIR with LVH in black patients with essential hypertension.Materials and Methods:A case-control study was conducted at the Centre Médical de Kinshasa (CMK), the Democratic Republic of the Congo, between January and December 2019. Cases and controls were hypertensive patients with and without LVH, respectively. The relationship between obesity indices, physical inactivity, parameters of glucose metabolisme and lipid disorders and LVH were assessed using linear and logistic regression analyses in simple and univariate exploratory analysis, respectively. When differences were observed between LVH and the independent variables, the effect of potential confounders was studied by adjustment in multiple linear regression and in conditional logistic regression in multivariate analysis. The coefficients of determinations (R2), the adjusted ORs and their 95% CI were calculated to determine the association between the LVH and the independent variablesResults:Eighty-eight cases (52 men) were compared to 132 controls (81 men). Nineteen percent of left ventricular mass (LVM) variation (19%) was predicted by age, 31.3% by the duration of hypertension, 44.4% by BMI, 42.5% by WC, 20% by glycemia, 44.8% by insulinemia and 43.7% by HOMAIR. In multiple linear regression analysis, duration of hypertension, Body Mass Index (BMI), insulinemia and HOMAIR explained 68.3% of the variability in the increase in LVM. In the logisitic model obesity multiplied the risk of LVH by 3 (aOR: 2.8, 95% CI (1.06-7.4), p = 0.038), IR by 8 (aOR: 8.4, 95: (3.7-15.7), p <0.001).Conclusion:Obesity and IR appear to be the main predictors of LVH. The comprehensive management of cardiovascular risk factors should be emphasized with particular attention to obesity and insulin resistance. A prospective black sub-saharan population based study with serial imaging remain essential to better understand subclinical LV deterioration over time and to confirm the role of insulin resistance in black sub-saharan hypertensives.

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Section: Discussionsupporting

confidence: 92%

Association between insulin resistance and left ventricular hypertrophy in sub-saharan hypertensive black patients with preserved ejection fraction: A case control study

Phanzu

Aliocha

Eleuthère

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Signi cantly higher uric acid levels were found in hypertensives with LVH than in those without LVH. This is in agreement with previous studies which have shown that hypertensives with LVH have higher uric acid levels [82]. A causal link was suggested since normalization of uric acid levels using hypouricaemic treatment led to a reduction in the LVM [83,84].…”

Section: Discussionsupporting

confidence: 92%

Association between insulin resistance and left ventricular hypertrophy in asymptomatic Black sub-Saharan African hypertensive patients: A case-control study

Phanzu

Aliocha

Eleuthère

et al. 2020

Preprint

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Background: Conflicting information exists regarding the association between insulin resistance (IR) and left ventricular hypertrophy (LVH). Here, we described the associations between parameters of obesity, fasting insulinaemia, homeostasis model assessment of insulin resistance (HOMA-IR) and LVH in Black patients with essential hypertension. Methods: A case-control study was conducted at the Centre Médical de Kinshasa (CMK), the Democratic Republic of the Congo, between January and December 2019. Cases and controls were hypertensive patients with and without LVH, respectively. The relationships between obesity indices, physical inactivity, parameters of glucose metabolism and lipid disorders and LVH were assessed using linear and logistic regression analyses in simple and univariate exploratory analyses, respectively. When differences were observed between LVH and the independent variables, the effect of potential confounders was studied by adjustment in multiple linear regression and conditional logistic regression in multivariate analysis. The coefficients of determination (R2), the adjusted ORs and their 95% CIs were calculated to determine the association between LVH and the independent variables. Results: Eighty-eight cases (52 men) were compared to 132 controls (81 men). Nineteen percent (19%) of left ventricular mass (LVM) variation was predicted by age; 31.3%, by the duration of hypertension; 44.4%, by body mass index (BMI); 42.5%, by waist circumference (WC); 20%, by glycaemia; 44.8%, by insulinaemia; and 43.7%, by HOMA-IR. In multiple linear regression analysis, duration of hypertension, BMI, insulinaemia and HOMA-IR explained 68.3% of the variability in the increase in LVM. In the logistic model, obesity multiplied the risk of LVH by 3 (aOR: 2.8, 95% CI (1.06-7.4), p = 0.038) and IR by 8 (aOR: 8.4, 95: (3.7-15.7), p <0.001). Conclusions: Obesity and IR appear to be the main predictors of LVH in Black sub-Saharan African hypertensive patients. The comprehensive management of cardiovascular risk factors should be emphasized with particular attention to obesity and IR. A prospective Black sub-Saharan population-based study with serial imaging remains essential to better understand subclinical LV deterioration over time and to confirm the role of IR in Black sub-Saharan individuals with hypertension.

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“…Hence, Catena et al have suggested that SUA may play only an independent role in a specific population, such as women patients of hypertension. In that study, the multivariate regression analysis showed that the association between SUA and LVH was independent from components of the metabolic syndrome and renal function in women, but not in men [9]. Similarly, Yu et al also found out that higher SUA level was significantly an independent risk factor for LVH in postmenopausal women (OR = 1.367; 95% CI 1.026–1.821), but not in premenopausal women (OR = 1.690; 95% CI 0.669–2.486) [10].…”

Section: Discussionmentioning

confidence: 99%

Increased Serum Uric Acid Level Is a Risk Factor for Left Ventricular Hypertrophy but Not Independent of eGFR in Patients with Type 2 Diabetic Kidney Disease

Zeng

Cheng

Sheng

et al. 2017

Journal of Diabetes Research

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Background Although the relation between serum uric acid (SUA) and left ventricular hypertrophy (LVH) has been studied for decades, however, their association remains debatable. Methods This is a retrospective study in which a total of 435 hospitalized Chinese patients with type 2 DKD were enrolled. The subjects were stratified into quartiles according to SUA level. LVH was assessed by two-dimensional guided M-mode echocardiography. Results There was a significant increase in the prevalence of LVH in patients with type 2 DKD across SUA quartiles (28.9, 26.5, 36.1, and 49.5%; p < 0.001). The Spearman analysis indicated that SUA was positively correlated to LVMI and negatively correlated to eGFR. The logistic regression analysis revealed that the odd ratio for LVH in the highest SUA quartile was 2.439 (95% CI 1.265–4.699; p = 0.008; model 1) or 2.576 (95% CI 1.150–5.768; p = 0.021; model 2) compared with that in the lowest SUA quartile. However, there was no significant increased risk of LVH in the subjects with the highest SUA quartile after adjusting the eGFR (OR = 1.750; 95% CI 0.685–4.470; p = 0.242; model 3). Conclusions In selected population, such as type 2 DKD, the elevated SUA level is positively linked with the increased risk of LVH, but this relationship is not independent of eGFR.

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Uricaemia and left ventricular mass in hypertensive patients

Abstract: Elevated uric acid levels are independently related to the left ventricular mass in hypertensive women without the metabolic syndrome. In these patients with a low cardiovascular risk profile, uric acid might contribute to the development of subclinical cardiac damage.

Cited by 23 publications

References 39 publications

Association between insulin resistance and left ventricular hypertrophy in sub-saharan hypertensive black patients with preserved ejection fraction: A case control study

Association between insulin resistance and left ventricular hypertrophy in sub-saharan hypertensive black patients with preserved ejection fraction: A case control study

Association between insulin resistance and left ventricular hypertrophy in asymptomatic Black sub-Saharan African hypertensive patients: A case-control study

Increased Serum Uric Acid Level Is a Risk Factor for Left Ventricular Hypertrophy but Not Independent of eGFR in Patients with Type 2 Diabetic Kidney Disease

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