Uridine adenosine tetraphosphate acts as an autocrine hormone affecting glomerular filtration rate

Jankowski, Vera; Patzak, Andreas; Herget–Rosenthal, Stefan; Tran, Thi Nguyet Anh; Lai, En Yin; Günthner, Thomas; Buschmann, Ivo; Zidek, Walter; Jankowski, Joachim

doi:10.1007/s00109-008-0306-6

Cited by 28 publications

(43 citation statements)

References 21 publications

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“…Up4A is a recently-identified, nonpeptide, endothelium-derived vasoconstrictor (1,2). Up4A is likely associated with blood pressure regulation, because its levels in plasma are elevated in hypertensive subjects (3) and it causes vasoconstriction in deoxycorticosterone acetate-salt hypertensive rats (4) and type 2 diabetic rats (5).…”

mentioning

confidence: 99%

Uridine adenosine tetraphosphate is a novel neurogenic P2Y1 receptor activator in the gut

Durnin

Hwang

Kurahashi

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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confidence: 99%

Uridine adenosine tetraphosphate is a novel neurogenic P2Y1 receptor activator in the gut

Durnin

Hwang

Kurahashi

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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“…ATP can also relax glomeruli via P2Y receptors on endothelial cells resulting in release of nitric oxide (NO), supporting the notion that P2 receptors influence glomerular filtration rate (GFR) [166]. Uridine adenosine tetraphosphate may also act as an autocrine hormone affecting glomerular filtration rate [170]. Tubular sodium transport systems are more sensitive to diadenosine tetraphosphate (Ap 4 A) than systems involved in glomerular filtration rates [167].…”

Section: Glomerulus and The Renal Vasculaturementioning

confidence: 92%

Purinergic signalling in the kidney in health and disease

Burnstock

Evans

Bailey

2013

Purinergic Signalling

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The involvement of purinergic signalling in kidney physiology and pathophysiology is rapidly gaining recognition and this is a comprehensive review of early and recent publications in the field. Purinergic signalling involvement is described in several important intrarenal regulatory mechanisms, including tuboglomerular feedback, the autoregulatory response of the glomerular and extraglomerular microcirculation and the control of renin release. Furthermore, purinergic signalling influences water and electrolyte transport in all segments of the renal tubule. Reports about purine-and pyrimidine-mediated actions in diseases of the kidney, including polycystic kidney disease, nephritis, diabetes, hypertension and nephrotoxicant injury are covered and possible purinergic therapeutic strategies discussed.

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“…Subsequently, Up 4 A was found to be released by cultivated renal proximal tubule cells (22). It remains unknown whether Up 4 A is also released by cells of the gastrointestinal system.…”

Section: Discussionmentioning

confidence: 99%

Uridine adenosine tetraphosphate induces contraction of circular and longitudinal gastric smooth muscle by distinct signaling pathways

Yuan

Wang

et al. 2013

IUBMB Life

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Extracellular nucleotides uridine-5 0 -triphosphate (UTP) and adenosine-5 0 -triphosphate (ATP) induce contraction of gastric smooth muscle (SM). The dinucleotide uridine adenosine tetraphosphate (Up 4 A), an endothelium-derived contraction factor, induces vascular SM contraction. Its effect on gastric SM contractions, however, is unknown. We addressed the hypothesis that Up 4 A induces gastric SM contraction via a mechanism that may differ between circular and longitudinal muscle (CM and LM, respectively). CM and LM were isolated from rat gastric fundus for the measurement of isometric tension. Up 4 A induced transient contractile responses in both CM and LM, which were similar to those induced by ATP and UTP. Up 4 A failed to induce contraction of either LM or CM in the absence of extracellular Ca 21 or in the presence of nimodipine, an inhibitor of voltagegated Ca 21 channels. P2X1, 2, 4, 5 and 7 and P2Y1, 2, 4 and 6 receptor expression was detected in gastric SM by reverse transcription-polymerase chain reaction. IP 5 I (a P2X receptor antagonist) and a,b-methylene-ATP (a P2X receptor agonist) had no effect on Up 4 Ainduced contractions of either LM or CM, and a,b-methylene-ATP alone failed to induce a contractile response in either tissue. Suramin (a P2Y receptor antagonist), on the other hand, significantly inhibited Up 4 A-induced contraction of CM, but not LM. Up 4 Ainduced contraction of CM, but not LM, was also inhibited by pretreatment with Y-27632, an inhibitor of Rho-associated kinase. We conclude that Up 4 A induces extracellular Ca 21 -dependent contractions of rat gastric LM and CM, and Up 4 A-induced contraction of CM is mediated by suramin-sensitive P2Y receptors and subsequent activation of the Rho-associated kinase pathway. V C 2013 IUBMB Life, 65(7): [623][624][625][626][627][628][629][630][631][632] 2013

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Uridine adenosine tetraphosphate acts as an autocrine hormone affecting glomerular filtration rate

Cited by 28 publications

References 21 publications

Uridine adenosine tetraphosphate is a novel neurogenic P2Y1 receptor activator in the gut

Uridine adenosine tetraphosphate is a novel neurogenic P2Y1 receptor activator in the gut

Purinergic signalling in the kidney in health and disease

Uridine adenosine tetraphosphate induces contraction of circular and longitudinal gastric smooth muscle by distinct signaling pathways

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