Ürik Asidin Antioksidan ve Pro-Oksidan Özellikleri ile İlgili Kavram ve Tartışmalarının Derlemesi

Abstract

Uric acid, the end product of purine catabolism in humans and is known for its crystal deposition at higher concentrations (>7 mg/dl) in gout. Less is known about its antioxidant property and the beneficial effects in various diseases. It is thought that high concentration of uric acid in humans is an evolutionary advantage and it is also hypothesized that high concentration of uric acid is to compensate the antioxidant capacity of ascorbic acid which is lost in humans during the course of evolution. In the extracelluar environment, uric acid can scavenge free radicals like hydroxyl radical, singlet oxygen and peroxynitrite radical therefore, it is considered as a powerful antioxidant. On the other hand uric acid depending upon the chemical milieu, changing its property and at times it acts as pro oxidant and is associated with the pathobiochemistry in developing various diseases like hypertension, cardio vascular diseases, ischemia reperfusion injury, diabetes mellitus, non alcoholic fatty liver disorders etc. In this review, we tried to summarize the evolutionary advantages of hyperuricaemia, effects of both antioxidant property and pro-oxidant nature of uric acid in various disease conditions.

Simultaneous Analysis of Ascorbic Acid, Uric Acid, and Dopamine at Bare Polystyrene Thermoplastic Electrodes

“…These sensors therefore are good for detection of higher UA concentrations in the presence of AA and DA, however, for simultaneous analysis UA concentrations need to be diluted to ≤50 μM. Healthy uric acid levels in the body are 89–387 μM with levels exceeding that indicating hyperuricemia, [46] and uric acid is excreted in urine at ∼2 m m concentrations [42] …”

“…These sensors therefore are good for detection of higher UA concentrations in the presence of AA and DA, however, for simultaneous analysis UA concentrations need to be diluted to � 50 μM. Healthy uric acid levels in the body are 89-387 μM with levels exceeding that indicating hyperuricemia, [46] and uric acid is excreted in urine at ~2 mm concentrations. [42] From the single analyte calibration data, concentration ranges were chosen for simultaneous calibration where the signal response was linear and there was no noticeable interference between the three analytes.…”