Urinary 1-naphthol excretion in the assessment of exposure to creosote in an impregnation facility

Heikkilä, Pirjo; Luotamo, Marita; Riihimäki, Vesa

doi:10.5271/sjweh.199

Cited by 22 publications

(17 citation statements)

References 16 publications

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“…The adjusted geometric mean of urinary 1-hydroxypyrene in the Special Operations Command group was 159 ng/L or 0.72 µmol/mol creatinine. This value is similar to median values in another firefighter study (Caux et al 2002), much less than mean values seen in other occupational studies (Heikkila et al 1997;Van Schooten et al 1995;VanRooij et al 1992;Venier et al 1985), and similar to reported levels in firefighters during a training exercise (Feunekes et al 1997 Abbreviations: CI, confidence interval; HCDBF, heptachlorodibenzofuran. Listed chemicals in this table were initially significant at p < 0.05 for differences between any of the six exposure groups using the chi-square test.…”

Section: Discussionsupporting

confidence: 84%

Biomonitoring of chemical exposure among New York City firefighters responding to the World Trade Center fire and collapse.

Edelman

Osterloh

Pirkle

et al. 2003

Environ Health Perspect

119

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The collapse of the World Trade Center (WTC) on 11 September 2001 exposed New York City firefighters to smoke and dust of unprecedented magnitude and duration. The chemicals and the concentrations produced from any fire are difficult to predict, but estimates of internal dose exposures can be assessed by the biological monitoring of blood and urine. We analyzed blood and urine specimens obtained from 321 firefighters responding to the WTC fires and collapse for 110 potentially fire-related chemicals. Controls consisted of 47 firefighters not present at the WTC. Sampling occurred 3 weeks after 11 September, while fires were still burning. When reference or background ranges were available, most chemical concentrations were found to be generally low and not outside these ranges. Compared with controls, the exposed firefighters showed significant differences in adjusted geometric means for six of the chemicals and significantly greater detection rates for an additional three. Arrival time was a significant predictor variable for four chemicals. Special Operations Command firefighters (n = 95), compared with other responding WTC firefighters (n = 226), had differences in concentrations or detection rate for 14 of the chemicals. Values for the Special Operations Command firefighters were also significantly different from the control group values for these same chemicals and for two additional chemicals. Generally, the chemical concentrations in the other firefighter group were not different from those of controls. Biomonitoring was used to characterize firefighter exposure at the WTC disaster. Although some of the chemicals analyzed showed statistically significant differences, these differences were generally small.

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Section: Discussionsupporting

confidence: 84%

Biomonitoring of chemical exposure among New York City firefighters responding to the World Trade Center fire and collapse.

Edelman

Osterloh

Pirkle

et al. 2003

Environ Health Perspect

119

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“…Inhalable pyrene and benzo(a)pyrene have shown correlations as good as r=0.97 (n=45) in the personal air samples of cokery workers (Kuljukka et al 1996). Urinary 1-naphthol (but not 1-OHP) is a valid index for the body dose of inhaled naphthalene and possible other gaseous PAHs too (Heikkila¨et al 1997;Elovaara et al 1995).…”

Section: Introductionmentioning

confidence: 96%

“…Naphthalene, phenanthrene, and pyrene are dominant constituents in PAH mixtures, Fig. 1 Heikkila¨et al 1997). Monohydroxylated metabolites (OH-metabolites) of these hydrocarbons are used as biomarkers of internal dose, and are determined in urine by various methods.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous analysis of naphthols, phenanthrols, and 1-hydroxypyrene in urine as biomarkers of polycyclic aromatic hydrocarbon exposure: intraindividual variance in the urinary metabolite excretion profiles caused by intervention with β-naphthoflavone induction in the rat

2003

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Two fluorimetric HPLC methods are described for the quantification of naphthols, phenanthrols and 1-hydroxypyrene (1-OHP) in urine specimens obtained from male Wistar rats exposed to naphthalene, phenanthrene and pyrene. The polycyclic aromatic hydrocarbons (PAHs) were given intraperitoneally, either alone (1.0 mmol/kg body weight) or as an equimolar mixture (0.33 mmol/kg), using the same dosages for repeated treatments on week 1 and week 2. Between these treatments, PAH-metabolizing activities encoded by aryl hydrocarbon (Ah) receptor-controlled genes were induced in the rats with beta-naphthoflavone (betaNF). Chromatographic separation of five phenanthrols (1-, 2-, 3-, 4-, and 9-isomers) was accomplished using two different RP C-18 columns. Despite selective detection (programmable wavelengths), the quantification limits in the urine ranged widely: 1-OHP (0.18 microg/l)

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“…Creosote impregnation plants are known sources of airborne polycyclic aromatic hydrocarbons (PAHs) in the environment (Elovaara et al 1995;HeikkilaÈ et al 1997). Owing to the carcinogenic potential of several individual PAH compounds and PAH mixtures (IARC 1984(IARC , 1985(IARC , 1987, these contaminants are considered as priority pollutants in Canada (Meek et al 1994).…”

Section: Introductionmentioning

confidence: 98%

Biological monitoring of environmental exposure to polycyclic aromatic hydrocarbons in subjects living in the vicinity of a creosote impregnation plant

Bouchard¹,

Pinsonneault²,

Tremblay³

et al. 2001

International Archives of Occupational and Environmental Health

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Urinary 1-naphthol excretion in the assessment of exposure to creosote in an impregnation facility

Cited by 22 publications

References 16 publications

Biomonitoring of chemical exposure among New York City firefighters responding to the World Trade Center fire and collapse.

Biomonitoring of chemical exposure among New York City firefighters responding to the World Trade Center fire and collapse.

Simultaneous analysis of naphthols, phenanthrols, and 1-hydroxypyrene in urine as biomarkers of polycyclic aromatic hydrocarbon exposure: intraindividual variance in the urinary metabolite excretion profiles caused by intervention with β-naphthoflavone induction in the rat

Biological monitoring of environmental exposure to polycyclic aromatic hydrocarbons in subjects living in the vicinity of a creosote impregnation plant

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