URINARY 3-HYDROXYBENZO[<i>A</i>]PYRENE AS A BIOMARKER OF EXPOSURE TO POLYCYCLIC AROMATIC HYDROCARBONS: AN APPROACH FOR DETERMINING A BIOLOGICAL LIMIT VALUE

Lafontaine, Michel; Gendre, Catherine; Delsaut, P.; Simon, P.

doi:10.1080/10406630490471447

Cited by 35 publications

(29 citation statements)

References 15 publications

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“…A study by Lafontaine et al 23 by the INRS laboratory assessed 3OH-BaP exposure of workers in aluminium factories, an artificial shooting target plant, carbon brake disk factories, an electrometallurgy plant and a creosoting plant using the method of Simon et al 12 They detected 3OH-BaP concentrations in a range of 0.3 ng/g crea (creosoting plant) to 83 ng/g crea (carbon brake disk factory). Those results are in the same range as ours, with maximum concentrations of 20 ng/g crea, even though there are differences in the sampling time between the studies.…”

Section: Resultsmentioning

confidence: 99%

3-Hydroxybenzo[a]pyrene in the urine of workers with occupational exposure to polycyclic aromatic hydrocarbons in different industries

et al. 2007

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3OH-BaP as a metabolite of the carcinogenic BaP could be shown to be a diagnostically specific and sensitive biomarker for determining the internal exposure of workers in different industries. Using this method, the estimation of health risks for workers can be fundamentally improved, because the 3OH-BaP represents the group of carcinogenic PAHs. The procedure for analysing 3OH-BaP is complex, but it is robust and produces reliable results.

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Section: Resultsmentioning

confidence: 99%

3-Hydroxybenzo[a]pyrene in the urine of workers with occupational exposure to polycyclic aromatic hydrocarbons in different industries

et al. 2007

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“…Urinary 3-OHBaP has already been measured in diff erent populations exposed to PAH occupationally (Forster et al, 2008;Gendre et al, 2002Gendre et al, , 2004Lafontaine et al, 2004) or non-occupationally (Fan et al, 2006;Godschalk et al, 1998;Lafontaine et al, 2006;Wang et al, 2005). However, a good correlation between BaP atmospheric concentrations and 3-OHBaP urinary concentrations is not always found, due in part to the use of individual protective devices (Maître et al, 2008) but also to the sampling time (Forster et al, 2008).…”

Section: Introductionmentioning

confidence: 93%

A toxicokinetic study to elucidate 3‐hydroxybenzo(a)pyrene atypical urinary excretion profile following intravenous injection of benzo(a)pyrene in rats

Marie

Bouchard

Heredia-Ortiz

et al. 2010

J of Applied Toxicology

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The toxicokinetics of benzo(a)pyrene (BaP) and 3-hydroxybenzo(a)pyrene (3-OHBaP) were assessed in 36 male Sprague-Dawley rats injected intravenously with 40 micromol kg(1) of BaP to explain the reported atypical urinary excretion profile of 3-OHBaP. Blood, liver, kidney, lung, adipose tissue, skin, urine and feces were collected at t = 2, 4, 8, 16, 24, 33, 48, 72 h post-dosing. BaP and 3-OHBaP were measured by high-performance liquid chromatography/fluorescence. A biexponential elimination of BaP was observed in blood, liver, skin and kidney (t((1/2)) of 4.2-6.1 h and 12.3-14.9 h for initial and terminal phases, respectively), while a monoexponential elimination was found in adipose tissue and lung (t((1/2)) of 31.2 and 31.5 h, respectively). A biexponential elimination of 3-OHBaP was apparent in blood, liver and skin (t((1/2)) of 7.3-11.7 h and 15.6-17.8 h for initial and terminal phases, respectively), contrary to adipose tissue, lung and kidney. In adipose tissue and lung, a monophasic elimination of 3-OHBaP was observed (t((1/2)) of 27.0 h and 24.1 h, respectively). In kidney, 3-OHBaP kinetics showed a distinct pattern with an initial buildup during the first 8 h post-dosing followed by a gradual elimination (t((1/2)) of 15.6 h). In the 72-h post-treatment, 0.21 +/- 0.09% (mean +/- SD) of dose was excreted as 3-OHBaP in urine and 12.9 +/- 1.0% in feces while total BaP in feces represented 0.40 +/- 0.16% of dose. This study allowed the identification of the kidney as a retention compartment governing 3-OHBaP atypical urinary excretion.

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“…This subject smoked 0.5-1 pack of cigarettes per day. The urinary excretion for 3-OHBaP in nurse A (figure 1) was somewhat higher than the level that is normally seen in smokers (26), but well below the biological limit value of 0.45 nmol/mol creatinine proposed by Lafontaine et al (10). The highest value at 4 hours prior to the application of CTO and the gradually decreasing pattern of values suggests an uptake of BaP on the previous day.…”

Section: Scheepers Et Almentioning

confidence: 83%

“…Pyrene and Scheepers et al 1-OHP, although not mutagenic, can be used as markers for total poorly volatile (particulate) PAH exposure and as indicators for systemic exposure to mutagenic PAH (9). Also benzo [a]pyrene (BaP) and 3-hydroxybenzo(a)pyrene (3-OHBaP) have been proposed as markers for external and internal exposure to carcinogenic (high molecular weight) PAH, respectively (10).…”

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confidence: 99%

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The occupational exposure of dermatology nurses to polycyclic aromatic hydrocarbons – evaluating the effectiveness of better skin protection

Scheepers¹,

Houtum²,

Anzion³

et al. 2009

Scand J Work Environ Health

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URINARY 3-HYDROXYBENZO[A]PYRENE AS A BIOMARKER OF EXPOSURE TO POLYCYCLIC AROMATIC HYDROCARBONS: AN APPROACH FOR DETERMINING A BIOLOGICAL LIMIT VALUE

Cited by 35 publications

References 15 publications

3-Hydroxybenzo[a]pyrene in the urine of workers with occupational exposure to polycyclic aromatic hydrocarbons in different industries

3-Hydroxybenzo[a]pyrene in the urine of workers with occupational exposure to polycyclic aromatic hydrocarbons in different industries

A toxicokinetic study to elucidate 3‐hydroxybenzo(a)pyrene atypical urinary excretion profile following intravenous injection of benzo(a)pyrene in rats

The occupational exposure of dermatology nurses to polycyclic aromatic hydrocarbons – evaluating the effectiveness of better skin protection

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