Urinary 3-phenoxybenzoic acid (3-PBA) levels and changes in hematological parameters in Korean adult population: A Korean National Environmental Health Survey (KoNEHS) 2012–2014 analysis

Choi, Yun-Hee; Lee, Ju-Yeon; Huh, Da An; Moon, Kyong Whan

doi:10.1016/j.ijheh.2022.113988

Cited by 6 publications

(2 citation statements)

References 43 publications

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“…Nevertheless, no clear differences in pyrethroid-related risk are observed between the EU and the included non-EU populations. As expected, exposure may be different in other jurisdictions, and, in fact, other studies have reported exposure levels in America and Asia above those from HBM4EU-aligned studies [56][57][58]. A more common finding is that exposure levels and the risk for children are higher than those for adults, suggesting to perform further studies in this sensitive population group.…”

Section: Overall Discussion Uncertainty Assessment and Final Risk Cha...mentioning

confidence: 67%

“…For example, the reported 95th percentiles for urinary 3-PBA in children ranged between 0.253 and 18.8 µg/L in Spain [54] and between 1.9 and 20.6 µg/L in the US [55]. The levels in adults are below those reported for US [56], Korea [57], or China [58]. Despite the large number of studies measuring urinary 3-PBA and, at a lesser extent, 4-FPBA concentrations, most of them do not report the 95th percentiles which is the level of exposure selected for our population risk assessment in order to cover the highest exposed group.…”

Section: Screening and Refined Assessments Based On Common Metabolitesmentioning

confidence: 88%

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A Tiered Approach for Assessing Individual and Combined Risk of Pyrethroids Using Human Biomonitoring Data

Tarazona

Cattaneo

Niemann

et al. 2022

Toxics

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Pyrethroids are a major insecticide class, suitable for biomonitoring in humans. Due to similarities in structure and metabolic pathways, urinary metabolites are common to various active substances. A tiered approach is proposed for risk assessment. Tier I was a conservative screening for overall pyrethroid exposure, based on phenoxybenzoic acid metabolites. Subsequently, probabilistic approaches and more specific metabolites were used for refining the risk estimates. Exposure was based on 95th percentiles from HBM4EU aligned studies (2014–2021) covering children in Belgium, Cyprus, France, Israel, Slovenia, and The Netherlands and adults in France, Germany, Israel, and Switzerland. In all children populations, the 95th percentiles for 3-phenoxybenzoic acid (3-PBA) exceeded the screening value. The probabilistic refinement quantified the risk level of the most exposed population (Belgium) at 2% or between 1–0.1% depending on the assumptions. In the substance specific assessments, the 95th percentiles of urinary concentrations in the aligned studies were well below the respective human biomonitoring guidance values (HBM-GVs). Both information sets were combined for refining the combined risk. Overall, the HBM data suggest a low health concern, at population level, related to pyrethroid exposure for the populations covered by the studies, even though a potential risk for highly exposed children cannot be completely excluded. The proposed tiered approach, including a screening step and several refinement options, seems to be a promising tool of scientific and regulatory value in future.

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Section: Overall Discussion Uncertainty Assessment and Final Risk Cha...mentioning

confidence: 67%

Section: Screening and Refined Assessments Based On Common Metabolitesmentioning

confidence: 88%

A Tiered Approach for Assessing Individual and Combined Risk of Pyrethroids Using Human Biomonitoring Data

Tarazona

Cattaneo

Niemann

et al. 2022

Toxics

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Study of pesticide transformation processes in different wheat varieties and their effects on plant metabolism

Pszczolińska,

Płonka,

Perkons

et al. 2024

Pest Management Science

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BACKGROUNDThis study aims to obtain systematic understanding of the way by which pesticides are metabolized in plants and the influence of this process on plants' metabolism as this process has a key impact on plant‐based food safety and quality. The research was conducted under field conditions, which enabled to capture metabolic processes taking place in plants grown under multihectare cultivation conditions.RESULTSResearch was conducted on three wheat varieties cultivated under field conditions and treated by commercially available preparations (fungicides, herbicides, insecticides, and growth regulator). Plant tissues with distinctions in roots, green parts, and ears were collected periodically during spring–summer vegetation period, harvested grains were also investigated. Sample extracts were examined by chromatographic techniques coupled with tandem mass spectrometry for: dissipation kinetics study, identification of pesticide metabolites, and fingerprint‐based assessment of metabolic changes.CONCLUSIONTissue type and wheat varieties influenced pesticide dissipation kinetics and resulting metabolites. Metabolic changes of plants were influenced by type of applied pesticide and its concentration in plants tissues. Despite differences in plant metabolic response to pesticide stress during cultivation, grain metabolomes of all investigated wheat varieties were statistically similar. 4‐[cyclopropyl(hydroxy)methylidene]‐3,5‐dioxocyclo‐hexanecarboxylic acid and trans‐chrysantemic acid – metabolites of crop‐applied trinexapac‐ethyl and lambda‐cyhalothrin, respectively, were identified in cereal grains. These compounds were not considered to be present in cereal grains up to now. The research was conducted under field conditions, enabling the measurement of metabolic processes taking place in plants grown under large‐scale management conditions. © 2024 Society of Chemical Industry.

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Exposure to biocides and their potential exposure sources among adults: A nationwide population-based study in South Korea

Choi,

Moon

2024

Chemosphere

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Urinary 3-phenoxybenzoic acid (3-PBA) levels and changes in hematological parameters in Korean adult population: A Korean National Environmental Health Survey (KoNEHS) 2012–2014 analysis

Cited by 6 publications

References 43 publications

A Tiered Approach for Assessing Individual and Combined Risk of Pyrethroids Using Human Biomonitoring Data

A Tiered Approach for Assessing Individual and Combined Risk of Pyrethroids Using Human Biomonitoring Data

Study of pesticide transformation processes in different wheat varieties and their effects on plant metabolism

Exposure to biocides and their potential exposure sources among adults: A nationwide population-based study in South Korea

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