Urinary 5–HIAA in Migraine: Evidence of Lowered Excretion in Young Adult Females

Bousser, Marie‐Germaine; Elghozi, Jean‐Luc; Laude, Dominique; Soisson, Thierry

doi:10.1046/j.1468-2982.1986.0604205.x

Cited by 20 publications

(16 citation statements)

References 16 publications

(26 reference statements)

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“…3 It has also been reported that urinary 5-HIAA excretion is decreased in both migraine types. 16 Our present data do not indicate any impairment of the degradation activity of serotonin in migraine with aura, since the levels of serotonin and 5-HIAA were strongly intercorrelated in a pattern similar to that of the controls. In migraine without aura and tension headache, however, no such significant correlation was observed, which may suggest some anomaly in serotonin catabolism.…”

Section: Commentssupporting

confidence: 49%

Metabolism and Menstrual Cycle Rhythmicity of Serotonin in Primary Headaches

et al. 1995

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We investigated the platelet and plasma levels of serotonin and its metabolite, 5-hydroxyindoleacetic acid, in patients suffering from episodic tension-type headache and migraine with and without aura, during a headache-free period. In female subjects, blood samples were drawn during the follicular, ovulatory, and late luteal phases of the menstrual cycle. In tension headache and migraine with aura, the group mean values of serotonin and 5-hydroxyindoleacetic acid in platelets and plasma were significantly increased, but migraine without aura patients' levels were normal. The pattern of menstrual cycle-related fluctuations in platelet serotonin levels were similar in female patients with tension headache and in controls, with a maximum value in the follicular phase. In both migraine groups, in contrast, the peak occurred in the ovulatory phase. The results are discussed in view of whether these aberrations in peripheral markers of the metabolism and menstrual cycle-related rhythmicity of serotonin may reflect similar alterations in the central nervous system.

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Section: Commentssupporting

confidence: 49%

Metabolism and Menstrual Cycle Rhythmicity of Serotonin in Primary Headaches

et al. 1995

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“…As discussed previously, there is experimental evidence to show that jaw-opening and closing reflexes are modulated by central serotonin In particular, it has been shown in the cat that stimulation of the raphe magnus inhibits the jaw-opening reflex evoked by tooth pulp stimulation (17). Modifications of serotonin metabolism have been reported in menstrual migraine (8,22), which has been ascribed to the physiological withdrawal of oestrogen during the premenstrual phase of the cycle (23). Several other neurochemical modifications have been observed during the premenstrual phase not only in women complaining of menstrual migraine, but also in those presenting with the premenstrual syndrome.…”

Section: Table 1 Temporalis Es2 (Mean ± Sem) At 01 and 2 Hz In The mentioning

confidence: 95%

Exteroceptive Silent Period of Temporalis Muscle in Menstrual Headaches

et al. 1991

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The second exteroceptive silent period (ES2) of temporalis muscle was recorded on days 1 and 15 of the menstrual cycle in 17 women, 9 of whom suffered regularly from tension-type headaches during menstruation. Mean duration of temporalis ES2 was significantly shorter on day 1 of the cycle than on day 15. This difference was due to a marked menstrual reduction of ES2 in the headache subgroup. A positive correlation was found between ES2 durations and oestradiol/progesterone ratios. We hypothesize that the variations of ES2 during the ovarian cycle result from the modulatory effects of oestrogens on descending aminergic pathways that control excitability of inhibitory brainstem interneurons mediating exteroceptive suppression of jaw-closing motoneurons.

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“…Two other studies found a declining tendency in urinary excretion of 5‐HIAA. Bousser et al presented evidence that urine 5‐HIAA excretion was significantly reduced in 35 adult young female migraineurs between migraine attacks. Milovanovic et al demonstrated the similar tendency of reduced urinary 5‐HIAA with a small sample (18 migraines).…”

Section: Neurotransmitters and Receptorsmentioning

confidence: 86%

The exploration of mechanisms of comorbidity between migraine and depression

Zhang

Shao

Jiang

et al. 2019

J Cellular Molecular Medi

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Migraine comorbid with depression is common and is often encountered in clinical practice. The comorbidity may lead to more serious conditions with other symptoms and a longer duration of treatment and it may impose heavy economic and social burdens, directly or indirectly, on patients and their families. Numerous studies have been published on the association of migraine with depression. Numerous literature have showed that the comorbidity may have a common complicated pathogenic mechanism involving biopsychosocial characteristics, including abnormal brain development and shared genetic basis, as well as neurotransmitters, sex hormones and stress. In addition, some studies have identified the multiple, bidirectional relationship between migraine and depressive disorder. We searched the literature for the possible common mechanisms between migraine and depression and classified the research results.

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Urinary 5–HIAA in Migraine: Evidence of Lowered Excretion in Young Adult Females

Cited by 20 publications

References 16 publications

Metabolism and Menstrual Cycle Rhythmicity of Serotonin in Primary Headaches

Metabolism and Menstrual Cycle Rhythmicity of Serotonin in Primary Headaches

Exteroceptive Silent Period of Temporalis Muscle in Menstrual Headaches

The exploration of mechanisms of comorbidity between migraine and depression

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