Urinary 6-Sulphatoxymelatonin Levels and Sleep Disorders in Children With Migraine

Abstract

We conducted the present study to assess melatonin secretion in a sample of children with migraine, to describe their sleep patterns and problems, and to examine the impact of sleep problems on migraine disability. The parents of 18 children with migraine completed the Children's Sleep Habits Questionnaire and Pediatric Migraine Disability Assessment Score in Arabic. The parents of 18 healthy controls also completed the Children's Sleep Habits Questionnaire. Urinary 6-sulphatoxymelatonin levels were determined with the enzyme-linked immunosorbent assay method. There was no significant difference in urinary 6-sulphatoxymelatonin between the migraine and control groups (Z = -0.127, P = .889). There were no significant differences between groups in Children's Sleep Habits Questionnaire subscales or total scores. There were significant correlations between bedtime resistance, parasomnias subscales, and migraine disability. Our findings indicate that nocturnal production of melatonin is not reduced in children with migraine, and sleep disturbances impact the degree of migraine disability.

How to Assess the Headache—Sleep Disorders Comorbidity in Children and Adolescents

“…None of the manuscripts mentioned the diagnostic criteria of the International Classification of Sleep Disorders (ICSD). However, different studies used validated questionnaires, including the Children's Sleep Habits Questionnaire (CSHQ) [10,26], Sleep Disturbances Scale for Children (SDSC) [24,28], Pediatric Daytime Sleepiness Scale (PDSS) [28], BEARS Sleep Screening Tool [21], and Sleep Hygiene Inventory for Pediatrics (SHIP) [22,23]. In some studies, other questionnaires, including the Patient-Reported Outcomes Measurement Information System (PROMIS) [19], general lifestyle questionnaire [20], and National Comorbidity Survey-Adolescent (NCS-A) [13], were used (Table 3).…”

Preliminary Evidence that Melatonin Is not a Biomarker in Children and Adolescents With Episodic Migraine

“…However, as children and adolescents are still undergoing neurodevelopment and neurohormonal development, it is important to study these age groups specifically as findings may differ from those of adults. Existing work indicates that salivary melatonin does not differ in children with episodic tension‐type headache nor does urinary melatonin differ in children with migraine …”

Wenig chronische Clusterkopfschmerz-Patienten in China

“…Auch in diesen Studien zeigte sich kein signifikanter Unterschied im Melatoninspiegel im Vergleich zu gesunden Kontrollpatienten [ 8 , 9 ]. Dies unterscheidet sich von den Studien zu Erwachsenen die einen Unterschied zwischen dem Melatoninhormonspiegel in Patienten mit Migräne im Vergleich zu Kontrollprobanden feststellen konnten [ 10 ]. In dieser Studie fehlt die Standardisierung der Schlafumgebung, da die Kinder und Jugendlichen in ihrem eigenen Bett zu Haue schlafen konnten.…”