Urinary 8-hydroxy-2'-deoxyguanosine excretion as a biomarker for estimating DNA oxidation in patients undergoing external radiotherapy and/or brachytherapy

Yamazaki, Hideya; Inoue, Takehiro; Koike, Masahiko; Tanaka, Eiichi; Yoshioka, Yasuo; Nakamura, Hajime; Xing, Shuo; Inoue, Toshihiko

doi:10.3892/or.13.5.847

Cited by 6 publications

(19 citation statements)

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“…Woo et al [58] compared urine samples from 10 breast, 9 ovarian and 12 cervical cancer patients as well as 22 normal controls, identifying 5-hydroxymethyl-2-deoxyuridine and 8-hydroxy-2-deoxyguanosine as biomarkers for BC. These markers had been suggested before as biomarkers for estimating DNA oxidation [60]. This signature is also similar to that observed by Henneges [54].…”

Section: Resultssupporting

confidence: 73%

Metabolomics Biomarkers for Breast Cancer

Günther

2015

Pathobiology

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Metabolomics represents a more recent addition to the range of omics tools, which are increasingly used in clinical applications. By measuring the composition of small molecules in tissues, blood or urine, it provides a sensitive molecular readout often associated with disease and its states, especially in cancer. Changes in metabolism related to cancer are increasingly well understood and are seen as a major hallmark of cancer. This review covers metabolomics used in human breast cancers, with a focus on its application in clinical diagnostics. There are clear indications that metabolomics could be a useful addition to currently established clinical diagnostic tools for breast cancer, including the possibility to detect cancer and to predict treatment responses and survival rates from blood and tissue samples.

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Section: Resultssupporting

confidence: 73%

Metabolomics Biomarkers for Breast Cancer

Günther

2015

Pathobiology

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“…Different results have been obtained in studies on the effects of radio/chemotherapy on 8-OHdG levels, 14,15,[20][21][22] which is why we did not include these groups in our study.…”

Section: Discussionmentioning

confidence: 91%

Measuring Oxidative DNA Damage With 8-Hydroxy-2’-Deoxyguanosine Levels in Patients With Laryngeal Cancer

Mazlumoglu¹,

Özkan

Hakan

et al. 2016

Ann Otol Rhinol Laryngol

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“…PTM peptide enrichment can employ either affinity 105 or chemical methods. 12,[106][107][108][109][110] During the MS analysis, multi-stage MS techniques that further fragment suspected PTM peptides 111 can improved confidence in peptide identification. Identification of PTMs commonly requires specialized bioinformatics tools, the validation of results by replicate analyses [42][43][44][45][46][47] and follow-up biological experiments.…”

Section: Methods For Ptm Discovery and Analysis Mass-spectrometry-basmentioning

confidence: 99%

Protein Modifications as Potential Biomarkers in Breast Cancer

Jin

Zangar

2009

Biomark�Insights

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A variety of post-translational protein modifications (PTMs) are known to be altered as a result of cancer development. Thus, these PTMs are potentially useful biomarkers for breast cancer. Mass spectrometry, antibody microarrays and immunohistochemistry techniques have shown promise for identifying changes in PTMs. In this review, we summarize the current literature on PTMs identified in the plasma and tumor tissue of breast-cancer patients or in breast cell lines. We also discuss some of the analytical techniques currently being used to evaluate PTMs.

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Urinary 8-hydroxy-2'-deoxyguanosine excretion as a biomarker for estimating DNA oxidation in patients undergoing external radiotherapy and/or brachytherapy

Cited by 6 publications

References 0 publications

Metabolomics Biomarkers for Breast Cancer

Metabolomics Biomarkers for Breast Cancer

Measuring Oxidative DNA Damage With 8-Hydroxy-2’-Deoxyguanosine Levels in Patients With Laryngeal Cancer

Protein Modifications as Potential Biomarkers in Breast Cancer

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