Urinary albumin/creatinine ratio as an early predictor of outcome in critically-ill septic patients

Tayeh, Osama; Taema, Khaled; Eldesouky, Mohamed I.; A, Omara

doi:10.1016/j.ejccm.2016.03.002

Cited by 7 publications

(7 citation statements)

References 35 publications

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“…In a study of critically ill septic adults done by Tayeh et al, 14) it was found that ACR2 was significantly elevated in those who required mechanical ventilation and inotropic support (P= 0.01 and P=0.009). it was found that ACR2 had AUC of 0.88 for mortality with a cut off value of 110.5 mg/g with 100% sensitivity and 86% specificity.…”

Section: Discussionmentioning

confidence: 92%

Comparative validity of microalbuminuria versus clinical mortality scores to predict pediatric intensive care unit outcomes

et al. 2020

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Section: Discussionmentioning

confidence: 92%

Comparative validity of microalbuminuria versus clinical mortality scores to predict pediatric intensive care unit outcomes

et al. 2020

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“…Tayeh et al reported that ACR at 24 h of admission was higher in patients who were mechanically ventilated, those requiring inotropes. Increasing ACR was found to be a predictor of mortality [15].…”

Section: Discussionmentioning

confidence: 91%

Comparison of urine albumin creatinine ratio with the pediatric index of mortality 2 score for prediction of pediatric intensive care unit outcomes

et al. 2021

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Background Predicting morbidity and mortality in a pediatric intensive care unit (PICU) is of extreme importance to make precise decisions for better outcomes. Aim We compared the urine albumin creatinine ratio (ACR) with the established PICU score, pediatric index of mortality 2 (PIM 2) for predicting PICU outcomes. Methods This cross-sectional study enrolled 67 patients admitted to PICU with systemic inflammatory response syndrome. Urine ACR was estimated on admission, and PIM 2 score was calculated. ACR was compared with PIM 2 for PICU outcome measures: the need for inotropes, development of multiple organ dysfunction syndrome (MODS), duration of PICU stay, and survival. Results Microalbuminuria was found in 77.6% of patients with a median ACR of 80 mg/g. ACR showed a significant association with the need for inotropes (p < 0.001), MODS (p = 0.001), and significant correlation to PICU stay (p 0.001, rho = 0.361). The area under the receiver operating characteristic curve for ACR (0.798) was comparable to that of PIM 2 (0.896). The cutoff value of ACR derived to predict mortality was 110 mg/g. The study subjects were divided into 2 groups: below cutoff and above the cutoff. Outcome variables, inotrope use, MODS, mortality, and PICU stay compared between these subgroups, were statistically significant. Conclusion ACR is a good predictor of PICU outcomes and is comparable to PIM 2 for mortality prediction.

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“…This condition leads to organ dysfunction and death. 1,11,12 In sepsis, platelets and leukocytes play an important role in inflammation. Platelets and neutrophils interact during inflammation, with reactions occurring on the endothelial surface.…”

Section: Discussionmentioning

confidence: 99%

“…Platelets and neutrophils interact during inflammation, with reactions occurring on the endothelial surface. 12 Platelets directly activate neutrophils and monocytes to migrate to the site of tissue destruction (chemotaxis). Furthermore, platelets also indirectly activate the interaction between neutrophils and monocytes, through several mechanisms, including triggering of neutrophil TREM-1, which leads to various pro-inflammatory responses.…”

Section: Discussionmentioning

confidence: 99%

The Platelet-to-lymphocyte ratio, PELOD-2 score, and mortality rate in pediatric sepsis

Rampengan

Joey

Kurniawan

et al. 2021

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Background Sepsis is life-threatening organ dysfunction caused by a regulated immune response to infection. Sepsis remains the most common cause of death in infants and children worldwide. The Pediatric Logistic Organ Dysfunction (PELOD-2) score, one of the most widely used scoring systems in pediatric sepsis patients, has been shown to be accurate in predicting mortality. The platelet-to-lymphocyte ratio (PLR) is a new clinical indicator of inflammation in a variety of diseases including sepsis. Objective To investigate the relationship between PLR, PELOD-2 score, and clinical outcomes in pediatric patients with sepsis. Methods This retrospective cohort study was conducted in the Pediatric Intensive Care Unit (PICU), Prof R.D. Kandou Hospital, Manado, North Sulawesi, from February to August 2020. Subjects’ PELOD-2 score and PLR were recorded once within the first 24 hours of PICU admission. We analyzed patients’ PELOD-2 score, PLR, and mortality rate, with 95% confidence interval (CI) for each value. Results Of 96 children with sepsis admitted to the PICU during the study period, 87 patients (46 boys; 52.9%) met the inclusion criteria. In total, 50 (57.47%) patients were non-survivors. Mean PLR values among survivors [77.54 (SD 50.08)] was significantly lower compared to the values among non-survivors [157.13 (SD 67.38)]; as well as the PELOD-2 score in the survivors group [12 (SD 1.32)] was significantly lower than its value in the non-survivors [14.65 (SD 2.09)]. Spearman’s analysis showed a moderately positive correlation between PLR and PELOD-2 score (r=0.444; 95%CI 0.44 to 1; P<0.01). Biserial point correlation analysis revealed a significant association between PLR and mortality rate (rpb=0.566; P<0.0001),with elevated PLR related to an increased risk of mortality. Conclusion There are positive correlations between PLR, PELOD-2 score, and mortality rate in pediatric patients with sepsis. Higher PLR and PELOD-2 score are associated with higher mortality.

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Urinary albumin/creatinine ratio as an early predictor of outcome in critically-ill septic patients

Cited by 7 publications

References 35 publications

Comparative validity of microalbuminuria versus clinical mortality scores to predict pediatric intensive care unit outcomes

Comparative validity of microalbuminuria versus clinical mortality scores to predict pediatric intensive care unit outcomes

Comparison of urine albumin creatinine ratio with the pediatric index of mortality 2 score for prediction of pediatric intensive care unit outcomes

The Platelet-to-lymphocyte ratio, PELOD-2 score, and mortality rate in pediatric sepsis

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