Urinary albumin excretion and transcapillary escape rate of albumin in malignancies

Lm, Pedersen; Terslev, Lene; Sørensen, PG; Kh, Stokholm

doi:10.1007/bf02796206

Cited by 12 publications

(10 citation statements)

References 26 publications

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“…An elevated urinary albumin excretion in patients with malignancies has been reported previously. 19 Interestingly, although the precise underlying mechanism is unknown, it has been speculated that in this type of patient, the increased urinary albumin loss appears to be more of an isolated renal phenomenon than to be related to endothelial dysfunction, because a normal endothelial function was observed, as demonstrated by the transcapillary escape rate of albumin, which suggests an overall unaffected capillary permeability. The present study adds considerable data to the available information on urinary albumin excretion as a vascular risk factor because we have used the full range of UAC in studying the relationship with mortality and did not cluster UAC levels into several categories.…”

Section: Hillege Et Al Urinary Albumin Concentration and Mortalitymentioning

confidence: 81%

Urinary Albumin Excretion Predicts Cardiovascular and Noncardiovascular Mortality in General Population

et al. 2002

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Background-For the general population, the clinical relevance of an increased urinary albumin excretion rate is still debated. Therefore, we examined the relationship between urinary albumin excretion and all-cause mortality and mortality caused by cardiovascular (CV) disease and non-CV disease in the general population. Methods and Results-In the period 1997 to 1998, all inhabitants of the city of Groningen, the Netherlands, aged between 28 and 75 years (nϭ85 421) were sent a postal questionnaire collecting information about risk factors for CV disease and CV morbidity and a vial to collect an early morning urine sample for measurement of urinary albumin concentration (UAC). The vital status of the cohort was subsequently obtained from the municipal register, and the cause of death was obtained from the Central Bureau of Statistics. Of these 85 421 subjects, 40 856 (47.8%) responded, and 40 548 could be included in the analysis. During a median follow-up period of 961 days (maximum 1139 days), 516 deaths with known cause were recorded. We found a positive dose-response relationship between increasing UAC and mortality. A higher UAC increased the risk of both CV and non-CV death after adjustment for other well-recognized CV risk factors, with the increase being significantly higher for CV mortality than for non-CV mortality (Pϭ0.014). A 2-fold increase in UAC was associated with a relative risk of 1.29 for CV mortality (95% CI 1.18 to 1.40) and 1.12 (95% CI 1.04 to 1.21) for non-CV mortality. Conclusions-Urinary albumin excretion is a predictor of all-cause mortality in the general population. The excess risk was more attributable to death from CV causes, independent of the effects of other CV risk factors, and the relationship was already apparent at levels of albuminuria currently considered to be normal.

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Section: Hillege Et Al Urinary Albumin Concentration and Mortalitymentioning

confidence: 81%

Urinary Albumin Excretion Predicts Cardiovascular and Noncardiovascular Mortality in General Population

et al. 2002

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“…Some studies have indicated that the extent of albuminuria reflects disease severity, showing high levels in patients with metastatic disease and large tumor burden. Therefore, albuminuria has been suggested as a nonspecific malignancy marker, reflecting microvascular responses and altered glomerular permeability in response to malignant cell products such as cytokines 8,20. However, studies assessing the relationship between proteinuria and all-cause mortality in patients with colorectal cancer are scarce.…”

Section: Introductionmentioning

confidence: 99%

Proteinuria as a Risk Factor for Mortality in Patients with Colorectal Cancer

et al. 2013

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PurposeWe investigated the effects of proteinuria and renal insufficiency on all-cause mortality in patients with colorectal cancer, with special emphasis on cancer staging and cancer-related deaths.Materials and MethodsWe retrospectively studied a cohort of patients with colorectal cancer. In protocol 1, patients were classified into four groups based on the operability of cancer and proteinuria: group 1, early-stage cancer patients (colorectal cancer stage ≤3) without proteinuria; group 2, early-stage cancer patients with proteinuria; group 3, advanced-stage cancer patients without proteinuria (colorectal cancer stage=4); and group 4, advanced-stage cancer patients with proteinuria. In protocol 2, patients were classified into four similar groups based on cancer staging and renal insufficiency (eGFR <60 mL/min/1.73 m2). Between January 1, 1998 and December 31, 2009, 3379 patients were enrolled in this cohort and followed until May 1, 2012 or until death.ResultsThe number of patients with proteinuria was 495 (14.6%). The prevalence of proteinuria was higher in advanced-stage cancer (n=151, 22.3%) than in early-stage cancer patients (n=344, 12.7%). After adjusting for age, gender and other clinical variables, the proteinuric, early-stage cancer group was shown to be associated with an adjusted hazard ratio of 1.67 and a 95% confidence interval of 1.38-2.01, compared with non-proteinuric early-stage cancer patients. However, renal insufficiency was not associated with colorectal cancer mortality.ConclusionProteinuria is an important risk factor for cancer mortality, especially in relatively early colorectal cancer.

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“…Several studies observed that serum albumin is a prognostic factor of survival in various cancer entities, but also in sarcomas . Lower levels of serum albumin are believed to be indicative of an ongoing systemic response to tumor cell products and inflammatory cytokines …”

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confidence: 99%

Serum creatinine and albumin predict sarcoma‐specific survival in patients with myofibroblastic and fibroblastic sarcomas

Willegger

Posch

Schieder

et al. 2017

Journal Orthopaedic Research

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Recent evidence suggests that common prognostic factors predicting disease progression and survival in soft tissue sarcomas (STS) are not applicable to all STS entities, indicating the need for histotype specific evaluation of new prognosticators. This study aimed at evaluating preoperative serum creatinine, albumin, and the albumin-creatinine ratio (ACR) as markers for survival in patients with malignant fibroblastic and myofibroblastic sarcomas. One hundred and thirty-two patients who underwent sarcoma resection have been included. Statistical analysis comprised uni- and multivariable Cox proportional hazard models, competing risk analysis and Kaplan-Meier estimates. The 5-year overall survival (OS) was estimated at 64.1% (95%CI: 53.7-72.8) and the 5-year sarcoma-specific mortality was 19.9% (95%CI: 12.8-28.1). Elevated serum creatinine levels were significantly associated with an impaired sarcoma-specific survival (SSS) adjusted for tumor stage (subdistribution hazard ratio (SHR) per 1 mg/dl increase: 3.27; 95%CI: 1.87-5.73; p < 0.0001). Low serum albumin levels were associated with a shorter recurrence-free survival (RFS) experience (HR per 10 g/L increase: 0.62; 95%CI: 0.41-0.94; p = 0.024). The ACR emerged as an AJCC-stage-independent prognosticator of SSS (SHR per 1 unit increase: 0.94; 95%CI: 0.90-0.98; p = 0.003). In conclusion, serum albumin and creatinine have been confirmed as predictive biomarkers for disease-specific outcomes in myofibroblastic and fibroblastic sarcomas. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:2815-2824, 2017.

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Urinary albumin excretion and transcapillary escape rate of albumin in malignancies

Cited by 12 publications

References 26 publications

Urinary Albumin Excretion Predicts Cardiovascular and Noncardiovascular Mortality in General Population

Urinary Albumin Excretion Predicts Cardiovascular and Noncardiovascular Mortality in General Population

Proteinuria as a Risk Factor for Mortality in Patients with Colorectal Cancer

Serum creatinine and albumin predict sarcoma‐specific survival in patients with myofibroblastic and fibroblastic sarcomas

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