Urinary and Pancreatic Juice Neopterin Excretion After Combined Pancreas-Kidney Transplantation

Tilg, Herbert; Königsrainer, Alfred; Krausler, R.; Aulitzky, W. E.; Margreiter, R; Reibnegger, Gilbert; Wachter, H; Huber, Christoph

doi:10.1097/00007890-199204000-00020

Cited by 6 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Extreme increases in the NEOP levels, however, occurred exclusively during cytomegalovirus diseases. The high diagnostic value of NEOP in the detection of viral infections corresponds to the findings of other groups [3,26]. In summary, SAA was the rejection marker with the highest diagnostic performance in the detection of pancreas rejections in this study.…”

Section: Discussionsupporting

confidence: 87%

Pancreas-specific protein (PASP), serum amyloid A [SAA), and neopterin (NEOP) in the diagnosis of rejection after simultaneous pancreas and kidney transplantation

Müller¹,

Trösch

Ebel

et al. 1997

Transplant Int

View full text Add to dashboard Cite

A reliable, noninvasive indicator of pancreatic allograft rejection is urgently needed. In this study, serum (S), plasma (P), and urine (U) levels of pancreas-specific protein (P-PASP, U-PASP), neopterin (S-NEOP, U-NEOP), amylase (U-AMYL), and amyloid A (SAA) were measured daily in ten type I diabetic patients following simultaneous pancreas and kidney transplantation (SPK). Rejection episodes occurred in three isolated pancreas, nine isolated kidney, and five simultaneous pancreas and kidney transplants. In the case of the eight pancreas rejections, SAA was the rejection marker with the highest diagnostic accuracy (94%). Using P-PASP and U-PASP, an accuracy of 81% and 79%, respectively, was achieved. During viral infections, U-NEOP levels increased to a maximum level of 1904 mumol/mol creatinine, whereas during bacterial infections, SAA levels increased to a maximum value of 43 mg/dl. SAA, measured for the first time in SPK, appears to be a valuable rejection parameter. In combination with U-NEOP and U-AMYL, a differential diagnosis between rejection, bacterial infection, and viral infection was possible. Neither U-PASP nor P-PASP monitoring led to a significant improvement in the results.

show abstract

Section: Discussionsupporting

confidence: 87%

Pancreas-specific protein (PASP), serum amyloid A [SAA), and neopterin (NEOP) in the diagnosis of rejection after simultaneous pancreas and kidney transplantation

Müller¹,

Trösch

Ebel

et al. 1997

Transplant Int

View full text Add to dashboard Cite

show abstract

“…Within the scope of our study, the concentrations of neopterin were also detected. Neopterin levels were determined in biological fluids, including blood, urine, cerebrospinal fluid (Molero‐Luis et al, 2020), tears (Baydar et al, 2016), synovial fluid (Zhou et al, 2013), pancreatic juice (Tilg et al, 1992), saliva (Mahendra et al, 2014), ascites (Haeger et al, 1996), and breast milk (Plata‐Nazar et al, 2015). Immediately after birth, the blood concentration of neopterin rises, similar to that observed in the third trimester, and then, it gradually decreases to pre‐pregnancy levels at about the 6th week.…”

Section: Discussionmentioning

confidence: 99%

Verification studies of tryptophan and kynurenine determination using HPLC and evaluation of the kynurenine pathway and neopterin levels in human colostrum samples

Girgin,

Sanajou,

Meric‐Deliveli

et al. 2023

Biomedical Chromatography

View full text Add to dashboard Cite

Colostrum, the first breast fluid produced by mammals after giving birth, is followed by breast milk, which serves as the sole source of nutrients for breastfed newborns and infants. Tryptophan, an essential amino acid, plays a crucial role in the development and maturation of the central nervous system in infants. Tryptophan is primarily degraded through the kynurenine pathway. Owing to its sensitivity to dietary intake, immune‐mediated tryptophan degradation is assessed by the kynurenine‐to‐tryptophan ratio, with a focus on one of the rate‐limiting enzymes in the pathway. This study involved the validation of the simultaneous determination of tryptophan and kynurenine using HPLC. The validated method was then used to detect levels of tryptophan and kynurenine, as well as to calculate the kynurenine‐to‐tryptophan ratio in colostrum samples. Simultaneously, these results were compared with colostrum neopterin levels measured using commercial enzyme‐linked immunosorbent assay kits. The mean levels for tryptophan, kynurenine, and neopterin were 17.3 ± 62.4 μM, 0.45 ± 0.03 μM, and 28.9 ± 2.6 nM, respectively. This study is among the few that have evaluated these parameters in colostrum samples. Neopterin levels secreted by the mammary gland were found not to be correlated with tryptophan degradation, a process influenced by the mother’s nutritional status.

show abstract

“…74 Multiple initial studies demonstrated success using this molecule to differentiate between liver allograft rejection and viral infections. 75,76 However, a 2015 study demonstrated that early post-LT measurements of serum neopterin were significantly correlated with 1-y survival in LT recipients. 77 Despite this, the pleiotropic actions of neopterin make achieving diagnostic specificity difficult.…”

Section: Introductionmentioning

confidence: 99%

New Approaches to the Diagnosis of Rejection and Prediction of Tolerance in Liver Transplantation

et al. 2022

View full text Add to dashboard Cite

show abstract

Urinary and Pancreatic Juice Neopterin Excretion After Combined Pancreas-Kidney Transplantation

Cited by 6 publications

References 0 publications

Pancreas-specific protein (PASP), serum amyloid A [SAA), and neopterin (NEOP) in the diagnosis of rejection after simultaneous pancreas and kidney transplantation

Pancreas-specific protein (PASP), serum amyloid A [SAA), and neopterin (NEOP) in the diagnosis of rejection after simultaneous pancreas and kidney transplantation

Verification studies of tryptophan and kynurenine determination using HPLC and evaluation of the kynurenine pathway and neopterin levels in human colostrum samples

New Approaches to the Diagnosis of Rejection and Prediction of Tolerance in Liver Transplantation

Contact Info

Product

Resources

About