Urinary and Serum Titanium: Assessment as an Indicator of Exposure to Ammonium Citratoperoxotitanate (IV) and Its Influence on Renal Function

Nakasuji, Kazuo; Usuda, Kan; Kawasaki, Takashi; Dote, Emi; Hayashi, Satsuki; Mitsui, Go; Adachi, Kazuya; Fujihara, Michiko; Shimbo, Yukari; Kono, Koichi

doi:10.1385/bter:110:2:119

Cited by 7 publications

(2 citation statements)

References 30 publications

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“…As described in a previous study by our group [17] and in other publications [1,2,[18][19][20], ICP-AES has been widely used for the determination of trace element concentrations, including REEs in a variety of samples [21][22][23].…”

Section: Discussionmentioning

confidence: 99%

Distribution, Elimination, and Renal Effects of Single Oral Doses of Europium in Rats

Ohnishi

Usuda

Nakayama

et al. 2011

Biol Trace Elem Res

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Single doses of europium (III) chloride hexahydrate were orally administered to several groups of rats. Cumulative urine samples were taken at 0-24 h, and blood samples were drawn after 24-h administration. The europium concentration was determined in these samples by inductively coupled plasma atomic emission spectroscopy. The volume, creatinine, ß-2-microglobulin, and N-acetyl-ß-D-glucosaminidase were measured in the urine samples to evaluate possible europium-induced renal effects. The blood samples showed low europium distribution, with an average of 77.5 μg/L for all groups. Although the urinary concentration and excretion showed dose-dependent increases, the percentage of europium excreted showed a dose-dependent decrease, with an average of 0.31% in all groups. The administration of europium resulted in a significant decrease of creatinine and a significant increase of urinary volume, N-acetyl-ß-D-glucosaminidase, and ß-2-microglobulin. Rare earth elements, including europium, are believed to form colloidal conjugates that deposit in the reticuloendothelial system and glomeruli. This specific reaction may contribute to low europium bioavailability and renal function disturbances. Despite low bioavailability, the high performance of the analytical method for determination of europium makes the blood and urine sampling suitable tools for monitoring of exposure to this element. The results presented in this study will be of great importance in future studies on the health impacts of rare earth elements.

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Section: Discussionmentioning

confidence: 99%

Distribution, Elimination, and Renal Effects of Single Oral Doses of Europium in Rats

Ohnishi

Usuda

Nakayama

et al. 2011

Biol Trace Elem Res

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“…Previous studies have shown that titanium and vanadium are excreted mainly through urine, and urinary concentrations of titanium and vanadium are good indicators for the exposure of the corresponding compounds (14,15). The present study evaluated the associations of urinary levels of titanium and vanadium with breast cancer risk in an ongoing case-control study carried out in Guangzhou, China.…”

Section: Introductionmentioning

confidence: 98%

Urinary Titanium and Vanadium and Breast Cancer: A Case-Control Study

Tang¹,

Su²,

He³

et al. 2012

Nutrition and Cancer

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Titanium and vanadium are essential trace elements. This study examined the associations of urinary titanium and vanadium with breast cancer risk in a hospital-based case-control study comprising 240 women with incident breast cancer, and 246 cancer-free and age-matched controls who attended health screening assessments in 2 affiliated hospitals of Sun Yat-sen University in Guangzhou between October 2009 and July 2010. Survey data and urine specimens were collected before treatment for the patients and after interview for the controls. The urinary concentrations of titanium and vanadium were measured by inductively coupled plasma mass spectrometry. Women in the second and the highest tertile of vanadium showed 64% and 40% decreased risk of breast cancer, respectively, when compared with those in the lowest tertile after adjustment for established risk factors of breast cancer (ORs [95%CI]: 0.36 [0.21-0.60] and 0.60 [0.37-0.97], respectively). In contrast, urinary titanium was not significantly related to a decreased risk of breast cancer. These results have potentially significant implications on nutritional chemoprevention of breast cancer and the development of new anticancer drugs. Further replications of the study are recommended, and the biological mechanisms warrant clarification.

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Urinary Monitoring of Exposure to Yttrium, Scandium, and Europium in Male Wistar Rats

Kitamura

Usuda

Shimizu

et al. 2012

Biol Trace Elem Res

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On the assumption that rare earth elements (REEs) are nontoxic, they are being utilized as replacements of toxic heavy metals in novel technological applications. However, REEs are not entirely innocuous, and their impact on health is still uncertain. In the past decade, our laboratory has studied the urinary excretion of REEs in male Wistar rats given chlorides of europium, scandium, and yttrium solutions by one-shot intraperitoneal injection or oral dose. The present paper describes three experiments for the suitability and appropriateness of a method to use urine for biological monitoring of exposure to these REEs. The concentrations of REEs were determined in cumulative urine samples taken at 0-24 h by inductively coupled plasma atomic emission spectroscopy, showing that the urinary excretion of REEs is <2 %. Rare earth elements form colloidal conjugates in the bloodstream, which make high REEs accumulation in the reticuloendothelial system and glomeruli and low urinary excretion. The high sensitivity of inductively coupled plasma-argon emission spectrometry analytical methods, with detection limits of <2 μg/L, makes urine a comprehensive assessment tool that reflects REE exposure. The analytical method and animal experimental model described in this study will be of great importance and encourage further discussion for future studies.

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Urinary and Serum Titanium: Assessment as an Indicator of Exposure to Ammonium Citratoperoxotitanate (IV) and Its Influence on Renal Function

Cited by 7 publications

References 30 publications

Distribution, Elimination, and Renal Effects of Single Oral Doses of Europium in Rats

Distribution, Elimination, and Renal Effects of Single Oral Doses of Europium in Rats

Urinary Titanium and Vanadium and Breast Cancer: A Case-Control Study

Urinary Monitoring of Exposure to Yttrium, Scandium, and Europium in Male Wistar Rats

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