Urinary angiogenic factors cluster hypertensive disorders and identify women with severe preeclampsia

Buhimschi, Catalin S.; Norwitz, Errol R.; Funai, Edmund F.; Richman, Susan; Guller, Seth; Lockwood, Charles J.; Buhimschi, Irina A.

doi:10.1016/j.ajog.2004.12.052

Cited by 138 publications

(82 citation statements)

References 28 publications

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“…In women with preeclampsia, concentrations of sFlt-1 are higher in those with early onset (Ͻ37 weeks), more severe disease (14,28,30,62 ), and SGA (small for gestational age) neonates (28,30,60 ). Urinary angiogenic markers have also been reported to be useful in the diagnosis of preeclampsia (63 ).…”

Section: Angiogenic Factors In the Diagnosis Of Preeclampsiamentioning

confidence: 99%

The Promise of Angiogenic Markers for the Early Diagnosis and Prediction of Preeclampsia

et al. 2012

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BACKGROUND An imbalance in circulating factors that regulate blood vessel formation and health, referred to as angiogenic factors, plays a central role in the pathogenesis of preeclampsia. CONTENT Several studies have demonstrated a strong association between altered circulating angiogenic factors and preeclampsia. These factors include circulating antiangiogenic proteins such as soluble fms-like tyrosine kinase 1 and soluble endoglin and proangiogenic protein such as placental growth factor. Abnormalities in these circulating angiogenic factors are not only present during clinical disease, but also antedate clinical signs and symptoms by several weeks. These alterations are particularly prominent in patients who present with preeclamptic signs and symptoms prematurely and/or in patients with severe preeclampsia. The availability of automated platforms for the rapid measurement of circulating angiogenic proteins in blood samples has now allowed researchers and clinicians to evaluate the utility of these assays in the diagnosis of the disease, in the stratification of patients in clinical trials, or in the monitoring of therapies. In this review we highlight the various studies that have been performed, with a focus on large validation studies. SUMMARY Measurement of circulating angiogenic proteins for the diagnosis and prediction of preeclampsia is still at an early stage but is rapidly evolving. Standardization across the various automated platforms and prospective studies that demonstrate clinical utility are needed.

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Section: Angiogenic Factors In the Diagnosis Of Preeclampsiamentioning

confidence: 99%

The Promise of Angiogenic Markers for the Early Diagnosis and Prediction of Preeclampsia

et al. 2012

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“…More recently, the excretion of anti-angiogenic proteins has been cited as a diagnostic feature of preeclampsia, 42 and in this issue, Garovic and colleagues introduce us to podocyturia. Podocyturia is the excretion of glomerular visceral epithelial cells or podocytes into the urine of preeclamptic women.…”

Section: Preeclampsia and Kidney Diseasesmentioning

confidence: 99%

Relationship between Urinary Podocytes and Kidney Diseases

Sun

Zhao

Li³

2012

Renal Failure

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Podocyte loss is an important component of disease progression in glomerular diseases. To some extent, the loss of podocytes can predict the degree of damage and the advancement of renal disease. Detecting the loss of podocytes in the urine could be a valuable, noninvasive method for obtaining information about the activity of the disease or the disease type, allowing the early diagnosis of glomerular diseases. One of the most robust markers that has been successfully used for urinary podocyte diagnostics is podocalyxin (PDX). PDX is a sialoprotein that is expressed on podocytes and on a variety of nonrenal cells as well as on glomerular endothelial and parietal epithelial cells. Therefore, podocyte loss can be detected by the amount of PDX in the urine. The relationship between urinary podocytes and renal diseases is supported by the detection of podocytes in patients with immunoglobulin A (IgA) nephropathy, HenochSchönlein purpura nephritis, lupus nephritis, diabetic nephropathy, and focal segmental glomerulosclerosis. The use of technology for detecting podocytes in the urine would have broad implications for the evaluation of disease activity, the degree of dedifferentiation, and the possibility of regeneration.

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“…A number of recent studies have suggested that circulating angiogenic factors in plasma or urine can be used to differentiate preeclampsia from other diseases that mimic preeclampsia such as chronic hypertension, gestational hypertension, lupus nephritis and gestational thrombocytopenia [47][48][49][50][51][52][53][54][55][56] . To demonstrate clinical utility, we prospectively studied the role of angiogenic biomarkers in the prediction of preeclampsia related adverse outcomes among women evaluated at our institution for suspected preeclampsia.…”

Section: Clinical Implications For Diagnosis and Treatment Of Preeclamentioning

confidence: 99%

New Developments in the Pathogenesis of Preeclampsia

Naljayan¹,

Karumanchi²

2013

Advances in Chronic Kidney Disease

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Preeclampsia affecting 3-5% of all pregnancies is a major cause of maternal and perinatal morbidity and mortality worldwide. This disorder is characterized by a constellation of signs and symptoms, most notably new onset hypertension and proteinuria during the last trimester of pregnancy. In this review, the molecular mechanisms of preeclampsia with an emphasis on the role of circulating anti-angiogenic proteins in the pathogenesis of preeclampsia and its complications will be discussed.

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Urinary angiogenic factors cluster hypertensive disorders and identify women with severe preeclampsia

Cited by 138 publications

References 28 publications

The Promise of Angiogenic Markers for the Early Diagnosis and Prediction of Preeclampsia

The Promise of Angiogenic Markers for the Early Diagnosis and Prediction of Preeclampsia

Relationship between Urinary Podocytes and Kidney Diseases

New Developments in the Pathogenesis of Preeclampsia

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