Urinary Angiotensinogen in Patients With Type 1 Diabetes With Microalbuminuria: Gender Differences and Effect of Intensive Insulin Therapy

Navarro, Jordan; Sánchez, Alejandro; Aqeel, Sheeba Habeeb Ba; Ye, Minghao; Rehman, Mohammed Z.; Wysocki, Jan; Rademaker, Alfred; Molitch, Mark E.; Batlle, Daniel

doi:10.1016/j.ekir.2022.09.010

Cited by 2 publications

(1 citation statement)

References 67 publications

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“…Such a connection was not confirmed by the results of the study International Diabetic Nephropathy Study (IDNS), where 243 young patients with diabetes found that total time is important for the development of diabetic nephropathy duration of diabetes (and not only the post-puberty period). In the available literature, studies have found in which the cumulative frequency of microalbuminuria in DM type 1 was 12% over a period of 7 years of follow-up [14,15]. When it comes to DM type 2 patients, the frequency of microalbuminuria is 2% per year, and after 10 years of disease duration, the prevalence of microalbuminuria is 25% [16].…”

Section: Discussionmentioning

confidence: 99%

Correlation between diabetic nephropathy and diabetic retinopathy as a long term complications of diabetes mellitus

Dervišević,

Rebić,

Dervišević

2023

Acta Marisiensis - Seria Medica

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Background/aim: Diabetes mellitus is a metabolic disorder of multiple etiologies characterized by a lack of insulin, with a consequent disordered metabolism of glucose, fats, and proteins. A number of complications, such as diabetic nephropathy and retinopathy, may develop as a result of long-term diabetes. The aim of this study aimed to determine the correlation between diabetic nephropathy and diabetic retinopathy as long-term complications of diabetes mellitus. Materials and methods: Retrospective, descriptive, and analytical research was conducted at the department of Endocrinology, Clinical Center, University of Sarajevo. The study included 158 patients hospitalized in time between 1st of January and 31st of December 2012. Results: New-onset diabetes was found in 38%, and diabetes type 2 patients 132 (83.5%), female 105 (66.5%) while older than 60 years were 100 (63.3%). Upon discharge from hospital 83,7% of patients were discharged with glycemia <10 mmol / l. We found that 47,5% of patients had HbA1c> 10%. Reduced kidney function, different degrees of failure was at 66.5%. More than half (62.7%) patients had proteinuria as a sign of diabetic nephropathy. Diabetic retinopathy was diagnosed with different types in 54.4%. Conclusion: Diabetes leads to an increase in nitrogen compounds, and the development of diabetic nephropathy manifests as various degrees of renal insufficiency. The duration of diabetes and occurrence of diabetic retinopathy were significantly interrelated. The correlation between the degree of renal failure and changes in the ocular fundus has not been proven, but more severe renal insufficiency is associated with a higher incidence of diabetic retinopathy compared to patients with less impaired renal function.

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Section: Discussionmentioning

confidence: 99%

Correlation between diabetic nephropathy and diabetic retinopathy as a long term complications of diabetes mellitus

Dervišević,

Rebić,

Dervišević

2023

Acta Marisiensis - Seria Medica

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Overview of the renin-angiotensin system in diabetic nephropathy

Karimi,

Maleki,

Movahedpour

et al. 2024

J Renin Angiotensin Aldosterone Syst

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Diabetes mellitus is a multifactorial hyperglycemic condition characterized by biochemical, molecular, and genetic variables, and leads to kidney dysfunction. Diabetic nephropathy (DN), referred to as diabetic kidney disease, is one of the major microvascular complications of diabetes, which is a major cause of end-stage renal disease and, consequently, high mortality. When DN occurs, it stimulates the renin-angiotensin system (RAS), one of the most significant indicators of developing renal impairment. Intrarenal RAS elements are upregulated in patients with DN, whereas systemic RAS elements are downregulated. Therefore, it is well accepted that the intra-renal RAS plays a key role in the onset of DN, characterized by the presence of protein in the urine and progressive decline in kidney function. RAS has two axes: 1- the renin, angiotensin-converting enzyme (ACE), angiotensin II (Ang II), and Ang II type 1 receptor (AT1R), 2- (ACE2, Ang 1-7, Ang 1-9, AT 2 receptor (AT2R), and Mas receptor (MasR). Blocking RAS with ACE inhibitors (ACEIs) and Ang II receptor blockers (ARBs) is currently a conventional therapy to protect the kidneys and inhibit DN progression and development in people with type 1 and type 2 diabetes.

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Urinary Angiotensinogen in Patients With Type 1 Diabetes With Microalbuminuria: Gender Differences and Effect of Intensive Insulin Therapy

Cited by 2 publications

References 67 publications

Correlation between diabetic nephropathy and diabetic retinopathy as a long term complications of diabetes mellitus

Correlation between diabetic nephropathy and diabetic retinopathy as a long term complications of diabetes mellitus

Overview of the renin-angiotensin system in diabetic nephropathy

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