Urinary Bile Acids

Back, Peter

doi:10.1007/978-1-4613-0901-7_11

Cited by 6 publications

(2 citation statements)

References 125 publications

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“…No attempt was made to separately analyze the individual bile acids with respect to their conjugation state other than to determine, by HPLC, the principal amidated bile acids. Previous studies of the bile of cystic fibrotic patients with liver disease (29) and serum of patients with PBC (30) have indicated that sulphated or glucuronidated bile acids are of minor quantitative importance (29); this is explained by the efficient renal excretion of these more polar conjugates (31). Furthermore, endogenous bile acids, including UDCA, were also measured in serum using precise and accurate techniques of .…”

Section: Discussionmentioning

confidence: 99%

Changes in bile acid composition in patients with primary biliary cirrhosis induced by ursodeoxycholic acid administration

et al. 1991

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We describe a detailed study of the effects of ursodeoxycholic acid administration on bile acid composition of the serum and bile of patients with primary biliary cirrhosis. Gas chromatography-mass spectrometry was used to analyze bile acids from 10 patients with primary biliary cirrhosis before and during ursodeoxycholic acid administration (500 mg/day, corresponding to approximately 8 mg/kg body wt), after group separation of the unconjugated and conjugated fractions by lipophilic anion exchange chromatography. These studies were directed at assessing whether the beneficial role of ursodeoxycholic acid in primary biliary cirrhosis was the consequence of a shift in the hydrophobic/hydrophilic balance of the bile acid pool and whether the hypercholeresis might result from the cholehepatic circulation of unconjugated ursodeoxycholic acid in bile. In basal conditions, the unconjugated bile acids accounted for only 5.5% and 2.5%, respectively, of the total bile acids of serum and bile; cholic acid was the major component of the conjugated fraction of serum and bile (56.0% +/- 4.0%, mean +/- S.E.M.), and ursodeoxycholic acid was present in only trace amounts. The conjugated fraction contained many unusual bile acids (representing 16.5% +/- 1.3% of total) including C25 bile acids, iso-chenodeoxycholic acid and several oxo-bile acids. After ursodeoxycholic acid administration biochemical indices of liver function all improved, but the proportions of the unconjugated bile acids in serum and bile did not significantly change.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionmentioning

confidence: 99%

Changes in bile acid composition in patients with primary biliary cirrhosis induced by ursodeoxycholic acid administration

et al. 1991

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“…Plasma levels are low (<10 M) because of effi cient hepatic extraction as well as dilution. Urinary levels are also low (<10 M) because only a fraction of plasma bile acids enter the glomerular fi ltrate, as bile acids are bound to plasma proteins, mostly to albumin ( 293 ). Moreover, much of the fraction of bile acids that enters the glomerular fi ltrate is reabsorbed in the proximal tubules via ASBT and OST ␣ / ␤ .…”

Section: Imaging Of Bile Acid Transport An 11mentioning

confidence: 99%

Key discoveries in bile acid chemistry and biology and their clinical applications: history of the last eight decades

Hofmann

Hagey

2014

Journal of Lipid Research

305

284

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conceptions are rare, and provocative judgments stand the test of time. Let us also hope that this effort will be both useful and entertaining. Each of the topics discussed merits at least a full length article, so there will be, of necessity in many instances, consideration of only what we perceive to be the highlights. THE EBB AND FLOW OF MEDICAL INTEREST IN BILE ACIDSAfter the elucidation of the true chemical structure of bile acids in 1932 (see below), there was little interest in bile acids in the Western world. One exception to this statement was the laboratory of Siegfried Thannhauser, who wrote the fi rst textbook of metabolic biochemistry in Germany. He studied cholesterol and bile acid balance in the biliary fi stula dog ( 1 ). During this time, bile acids were sold as liver tonics and laxatives, but there were no placebo-controlled studies showing effi cacy. Indeed, bile acids were considered by the medical profession to have no useful therapeutic properties. The tri-oxo derivative of cholic acid (called "dehydrocholic acid") was known to induce bile fl ow in animals ( 2 ), and was occasionally used to stimulate bile fl ow in patients; but again there were no controlled studies showing effi cacy in hepatobiliary disease.

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A novel enzyme system for the reduction of 3-oxo bile acids in human red blood cells

Goto¹,

Miura²,

Ando³

et al. 1996

Steroids

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Urinary Bile Acids

Cited by 6 publications

References 125 publications

Changes in bile acid composition in patients with primary biliary cirrhosis induced by ursodeoxycholic acid administration

Changes in bile acid composition in patients with primary biliary cirrhosis induced by ursodeoxycholic acid administration

Key discoveries in bile acid chemistry and biology and their clinical applications: history of the last eight decades

A novel enzyme system for the reduction of 3-oxo bile acids in human red blood cells

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