Urinary biomarkers for podocyte injury: Significance for evaluating the course and prognosis of chronic glomerulonephritis

Chebotareva, Natalia; Bobkova, Irina; Neprintseva, Natalia; Kozlovskaya, L V; Malkandueva, Z. T.

doi:10.17116/terarkh201587634-39

Cited by 9 publications

(3 citation statements)

References 18 publications

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“…In Russia, RBs were sometimes collected from patients with "inactive nephritic" or latent clinical forms of supposed Gn i.e. in caes of isolated proteinuria and/or hematuria (Chebotareva et al 2014;Ratner et al 1987aRatner et al , 1997Shilov et al 2002;Varshavskii et al 1992). At the same time, the classification of Gn has been different from that used internationally, which interfered with the implementation of recommendations from the international literature.…”

Section: Glomerulonephritis (Gn)mentioning

confidence: 99%

“…In conditions of insufficient quality of histological specimens, without silver impregnation and electron microscopy, such changes were sometimes overestimated and Gn overdiagnosed. As mentioned above, RBs were collected from patients with the "inactive nephritic" or latent clinical types of Gn i.e., minimal proteinuria and/or hematuria (Chebotareva et al 2014;Ratner et al 1987aRatner et al , 1997Shilov et al 2002;Varshavskii et al 1992). As a result of the histological overdiagnosis of Gn, some patients were treated by corticosteroids and/or cytotoxic drugs such as azathioprin, cyclophosphamide or chlorambucil (Krasnova et al 1991;Poliantseva et al 1990;Ratner et al 1979, 1987b, Serov et al 1992Tareeva et al 1989) without sufficient indications.…”

Section: Glomerulonephritis (Gn)mentioning

confidence: 99%

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Fascism in Medicine and Everyday Life

Jargin

2024

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Yudin SS. Metodika operacii pri ognestrelnyh perelomah bedra v usloviah sovremennoi voiny (Surgical methods for gunshot hip fractures in modern warfare). Moscow: Medgiz, 1943. Bronchial asthmaAnother method to be commented was the thoracic surgery with denervation of lungs as a treatment of bronchial asthma (Babichev et al. 1985;Gudovskii et al. 2002; Meshalkin and Alperin 1978; Smakov 1990) referred to as "the most accepted procedure" in the Instruction by the Health Ministry of RF (Health Ministry 1988). Among others, the "skeletonization" of pulmonary roots, auto-transplantation of lungs (complete removal with immediate reimplantation) (Meshalkin 1968; Meshalkin and Alperin 1978) or cross-section of trachea with

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Section: Glomerulonephritis (Gn)mentioning

confidence: 99%

Section: Glomerulonephritis (Gn)mentioning

confidence: 99%

Fascism in Medicine and Everyday Life

Jargin

2024

Preprint

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“…Chronic glomerulonephritis (CGN), the most common form of glomerular disease, accounts for ~20% of chronic kidney disease cases in many countries ( 1 , 2 ). CGN is associated with immune-mediated inflammatory diseases and is characterized by proteinuria, edema, hematuria and hypertension, which are accompanied by renal dysfunction which is a primary cause of end-stage of renal disease (ESRD) ( 3 , 4 ). Numerous pathogenic factors may promote the development of this disease; however, the molecular mechanisms remain unknown ( 5 , 6 ).…”

Section: Introductionmentioning

confidence: 99%

In�vitro and in�vivo study of the expression of the Syk/Ras/c‑Fos pathway in chronic glomerulonephritis

et al. 2018

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Chronic glomerulonephritis (CGN) is the most common form of glomerular disease; however, its associated molecular mechanisms remain unclear. Spleen tyrosine kinase (Syk) is a key mediator of B-receptor signaling on the surface of inflammatory cells. The primary target for R406 is Syk. The aim of the present study was to investigate the molecular mechanisms involved in a rat model of CGN induced by adriamycin (ADR) and in the rat glomerular mesangial cell line, HBZY-1, stimulated by lipopolysaccharide (LPS). CGN was induced in the rat models by two intravenous injections of ADR into the tail: 3.5 mg/kg ADR was given on the first day and 3.0 mg/kg on the fourteenth day. HBZY-1 cells were incubated with 0.5 µg/ml LPS for 48 h. The pathological alterations in the kidney tissues were observed by hematoxylin and eosin staining. The 24 h urinary protein, blood urea nitrogen (BUN) and creatinine levels were measured using an automatic biochemistry analyzer. The mRNA expression levels of Syk, Ras, mitogen activated protein kinase kinase (MEK), extracellular signal regulated kinase (ERK)1/2 and c-Fos was measured by reverse transcription-quantitative polymerase chain reaction. Subsequently, the protein levels of phosphorylated (p)-Syk, Ras, p-MEK1/2, p-ERK1/2 and c-Fos were measured by western blot analysis. In the model group, 24 h urinary protein, BUN and creatinine levels were increased when compared with the normal group (P<0.05). In addition, compared with the normal group, the mRNA and protein levels of the Syk/Ras/c-Fos pathway components in vitro and in vivo were markedly increased, inhibiting the abnormal cell viability of mesangial cells. In conclusion, the results of the present study suggested a potential role for the Syk/Ras/c-Fos signaling pathway in CGN, which indicated the necessity for further investigation at the clinical level.

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