Urinary biomarkers for the non-invasive diagnosis of endometriosis

Liu, Emily; Nisenblat, Vicki; Farquhar, Cindy; Fraser, Ian S.; Bossuyt, Patrick M.; Johnson, Neil; Hull, M. Louise

doi:10.1002/14651858.cd012019

Cited by 53 publications

(46 citation statements)

References 67 publications

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“…To date, no single biomarker or combination of biomarkers (e.g. endometrial, blood‐based, or urinary) has emerged as the standard for diagnosis of endometriosis . The lack of a definitive biomarker is not an indictment of those that have been studied, rather it reflects the state of the available evidence, which is constrained by studies with small sample sizes and other methodological limitations.…”

Section: Recommendations For Reshaping the Diagnosis Of Endometriosismentioning

confidence: 99%

An evidence‐based approach to assessing surgical versus clinical diagnosis of symptomatic endometriosis

Taylor

Adamson

Diamond

et al. 2018

Intl J Gynecology & Obste

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Challenges intrinsic to the accurate diagnosis of endometriosis contribute to an extended delay between the onset of symptoms and clinical confirmation. Intraoperative visualization, preferably with histologic verification, is considered by many professional organizations to be the gold standard by which endometriosis is diagnosed. Clinical diagnosis of symptomatic endometriosis via patient history, physical examination, and noninvasive tests, though more easily executed, is generally viewed as less accurate than surgical diagnosis. Technological advances and increased understanding of the pathophysiology of endometriosis warrant continuing reevaluation of the standard method for diagnosing symptomatic disease. A review of the published literature was therefore performed with the goal of comparing the accuracy of clinical diagnostic measures with that of surgical diagnosis. The current body of evidence suggests that clinical diagnosis of symptomatic endometriosis is more reliable than previously recognized and that surgical diagnosis has limitations that could be underappreciated. Regardless of the methodology used, women with suspected symptomatic endometriosis would be well served by a diagnostic paradigm that is reliable, conveys minimal risk of under- or over-diagnosis, lessens the time from symptom development to diagnosis, and guides the appropriate use of medical and surgical management strategies.

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Section: Recommendations For Reshaping the Diagnosis Of Endometriosismentioning

confidence: 99%

An evidence‐based approach to assessing surgical versus clinical diagnosis of symptomatic endometriosis

Taylor

Adamson

Diamond

et al. 2018

Intl J Gynecology & Obste

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“…However, urine accumulates changes 55 of the body, which makes it a better early biomarker source [22,23] . Urinary proteomics has 56 become increasingly important in studies of quantitative changes in proteins resulting 57 from changes in disease states [24][25][26][27][28] ; moreover, numerous urinary protein biomarkers 58 have been reported in different diseases [29][30][31][32] . These findings suggest that urinary proteins 59 may serve as non-invasive biomarkers for diseases.…”

mentioning

confidence: 99%

Early urinary candidate biomarker discovery in a rat thioacetamide-induced liver fibrosis model

Zhang

Yuan

et al. 2017

Preprint

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Biomarker is the change associated with the disease. Blood is relatively stable because of the homeostatic mechanisms of the body. However, urine accumulates changes of the body, which makes it a better early biomarker source. Liver fibrosis, which results from the deposition of extracellular matrix (ECM) components, is a reversible pathological condition, whereas cirrhosis, the end-stage of liver fibrosis, is irreversible. Consequently, noninvasive early biomarkers for fibrosis are desperately needed. In this study, differential urinary proteins were identified in the thioacetamide (TAA) liver fibrosis rat model using tandem mass tagging and two-dimensional liquid chromatography tandem mass spectrometry (2DLC-MS/MS). A total of 766 urinary proteins were identified, 143 and 118 of which were significantly changed in the TAA 1-week and 3-week groups, respectively. Multiple reaction monitoring (MRM)-targeted proteomics was used to further validate the abundant differentially expressed proteins in the TAA 1-week, 3-week, 6-week and 8-week groups. A total of 40 urinary proteins were statistically significant (fold change >2 and p<0.05), 15 of which had been previously reported as biomarkers of liver fibrosis, cirrhosis or other related diseases and 10 of which had been reported to be associated with the pathology and mechanism of liver fibrosis. These differential proteins were detected in urine before the alanine aminotransferase (ALT) and aspartate transaminase (AST) changes in the serum and before fibrosis was observed upon hematoxylin and eosin (HE) and Masson’s staining.

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“…There are no pathognomonic laboratory findings for endometriosis. A number of urinary and endometrial biomarkers have been examined for noninvasive diagnosis of the disease, but none have been clinically useful (15). Although the role of serum CA 125 in primary diagnosis is not defined (5), it may be increased in women with endometriosis (for example more than 35 units/mL) (16,17).…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Performance of Neutrophil/Lymphocyte Ratio and Platelet/Lymphocyte Ratio in Endometrioma

Aydın¹

2019

Istanbul Med J

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Amaç: Nötrofil/lenfosit oranı (NLR) ve trombosit/ lenfosit oranının (PLR) kronik enflamatuvar bir hastalık olan endometriomada tanı değerinin olup olmadığını değerlendirmektir. Yöntemler: Bu retrospektif, karşılaştırmalı olgu serisine adneksiyel kitle nedeniyle opere edilip patoloji sonucu endometrioma gelen 97 hasta ile kontrol grubu olarak patoloji sonucu benign kist (korpus luteum, seröz kist ya da fonksiyonel kistler) olan 90 hasta dahil edildi. Hastaların preoperatif dönemde hemogram parametrelerinden elde edilen NLR ve PLR değerleri iki grup arasında karşılaştırıldı. Bulgular: Endometrioma ve benign kist grubu yaş ortalamalarında istatistiksel anlamlı fark yoktu (sırasıyla 34,8±8,93 ve 34±8,59, p=0,88). Endometriomaların %14,4'ü (n=14) bilateraldi. Ortalama endometrioma boyutu 6±2,74 cm olarak belirlendi, %27,8'inin (n=27) 5 cm'den daha küçük olduğu saptandı. Endometrioma ile benign kist grubu arasında ortanca NLR değerleri açısından anlamlı bir fark saptanmadı (sırasıyla 1,848 ve 1,635, p=0,124). PLR ortanca değerleri endometriomada benign kiste göre anlamlı yüksek saptandı (sırasıyla; 128,77 ve 114,69, p=0,015). Bilateral endometriomalarda unilaterallere göre NLR oranının istatistiksel olarak anlamlı yüksek olduğu görüldü. Sonuç: NLR'nin endometrioma olgularında yüksek saptanmasa da bilateral olma durumundan etkilendiği görüldü. PLR'nin ise endometriomalı hastalarda yüksek olduğu ve hastalığın evresinden etkilenmediği tespit edildi.

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Urinary biomarkers for the non-invasive diagnosis of endometriosis

Cited by 53 publications

References 67 publications

An evidence‐based approach to assessing surgical versus clinical diagnosis of symptomatic endometriosis

An evidence‐based approach to assessing surgical versus clinical diagnosis of symptomatic endometriosis

Early urinary candidate biomarker discovery in a rat thioacetamide-induced liver fibrosis model

Diagnostic Performance of Neutrophil/Lymphocyte Ratio and Platelet/Lymphocyte Ratio in Endometrioma

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