Urinary biomarkers of exposure to 57 xenobiotics and its association with oxidative stress in a population in Jeddah, Saudi Arabia

Asimakopoulos, Alexandros G.; Xue, Jingchuan; Carvalho, Bruno Pereira De; Iyer, Archana; Abualnaja, Khalid Omer; Yaghmoor, Soonham; Kumosani, Taha; Kannan, Kurunthachalam

doi:10.1016/j.envres.2015.11.029

Cited by 227 publications

(115 citation statements)

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“…Oxidative stress is a purported factor of female reproductive disorders including endometriosis and polycystic ovary syndrome, which have implications for reduced fecundity (Agarwal et al 2012; Ruder et al 2008). In general, parabens have been correlated with the urinary biomarker of oxidative stress, 8-hydroxy-2´-deoxyguanosine, in humans (Asimakopoulos et al 2016), whereas MP and EP have are suspected of reacting with oxygen in the skin to produce a free radical or reactive oxygenated species (Nishizawa et al 2006). Also, higher concentrations of MP were measured in female than in male urine samples in the LIFE Study, which may reflect a greater use of personal care products among female partners (Manová et al 2013; Wu et al 2010), and may therefore partly explain our urinary MP and couple fecundity findings.…”

Section: Discussionmentioning

confidence: 99%

Urinary Concentrations of Parabens and Other Antimicrobial Chemicals and Their Association with Couples’ Fecundity

Smarr

Sundaram

Honda

et al. 2017

Environ Health Perspect

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112

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Background:Human exposure to parabens and other antimicrobial chemicals is continual and pervasive. The hormone-disrupting properties of these environmental chemicals may adversely affect human reproduction.Objective:We aimed to prospectively assess couples’ urinary concentrations of antimicrobial chemicals in the context of fecundity, measured as time to pregnancy (TTP).Methods:In a prospective cohort of 501 couples, we examined preconception urinary chemical concentrations of parabens, triclosan and triclorcarban in relation to TTP; chemical concentrations were modeled both continuously and in quartiles. Cox’s proportional odds models for discrete survival time were used to estimate fecundability odds ratios (FORs) and 95% confidence intervals (CIs) adjusting for a priori–defined confounders. In light of TTP being a couple-dependent outcome, both partner and couple-based exposure models were analyzed. In all models, FOR estimates < 1.0 denote diminished fecundity (longer TTP).Results:Overall, 347 (69%) couples became pregnant. The highest quartile of female urinary methyl paraben (MP) concentrations relative to the lowest reflected a 34% reduction in fecundity (aFOR = 0.66; 95% CI: 0.45, 0.97) and remained so when accounting for couples’ concentrations (aFOR = 0.63; 95% CI: 0.41, 0.96). Similar associations were observed between ethyl paraben (EP) and couple fecundity for both partner and couple-based models (p-trend = 0.02 and p-trend = 0.05, respectively). No associations were observed with couple fecundity when chemicals were modeled continuously.Conclusions:Higher quartiles of preconception urinary concentrations of MP and EP among female partners were associated with reduced couple fecundity in partner-specific and couple-based exposure models.Citation:Smarr MM, Sundaram R, Honda M, Kannan K, Buck Louis GM. 2016. Urinary concentrations of parabens and other antimicrobial chemicals and their association with couples’ fecundity. Environ Health Perspect 124:730–736; http://dx.doi.org/10.1289/EHP189

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Section: Discussionmentioning

confidence: 99%

Urinary Concentrations of Parabens and Other Antimicrobial Chemicals and Their Association with Couples’ Fecundity

Smarr

Sundaram

Honda

et al. 2017

Environ Health Perspect

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112

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“…Quantitative detection of phthalate metabolites was achieved utilizing a solid-phase extraction (SPE) method followed by enzymatic deconjugation of the glucuronidated phthalate monoesters coupled with high performance liquid chromatography electrospray ionization-tandem mass spectrometry (HPLC-ESI-MS/MS), as previously used (Asimakopoulos et al, 2016). Assay precision is improved by incorporating 13 C 4 - or 2 D 4 - isotopically-labeled internal standards for each of the phthalate metabolites.…”

Section: Methodsmentioning

confidence: 99%

Bisphenol and phthalate concentrations and its determinants among pregnant women in a population-based cohort in the Netherlands, 2004–5

Philips

Jaddoe²,

Asimakopoulos³

et al. 2018

Environmental Research

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132

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Background Exposure to bisphenols and phthalates in pregnancy may lead to adverse health effects in women themselves and their offspring. Objective To describe first trimester bisphenol and phthalate urine concentrations, including bisphenol and phthalate replacements, and determine nutritional, socio-demographic and lifestyle related determinants. Methods In a population-based prospective cohort of 1396 mothers, we measured first trimester bisphenol, phthalate and creatinine urine concentrations (samples collected in 2004–2005, median gestational age 12.9 weeks [inter-quartile range (IQR) 12.1–14.4]). We examined associations of potential determinants with log-transformed bisphenol and phthalate concentrations. Outcomes were back-transformed. Nutritional analyses were performed in a subgroup of 642 Dutch participants only, as the Food Frequency Questionnaire was aimed at Dutch food patterns. Results Bisphenol A, bisphenol S, and bisphenol F were detected in 79.2%, 67.8% and 40.2% of the population, respectively. Mono-n-butylphthalate, mono-(2-ethyl-5-hydroxyhexyl)phthalate and monobenzylphthalate were detected in > 90% of the population. Nutritional intake was not associated with bisphenol and phthalate concentrations after correction for multiple testing was applied. Obesity was associated with higher high-molecular-weight phthalate concentrations and the lack of folic acid supplement use with higher di-n-octylphthalate concentrations (respective mean differences were 46.73 nmol/l [95% CI 14.56–93.72] and 1.03 nmol/l [0.31–2.06]). Conclusion Bisphenol S and F exposure was highly prevalent in pregnant women in the Netherlands as early as 2004–5. Although associations of dietary and other key factors with bisphenol and phthalate concentrations were limited, adverse lifestyle factors including obesity and the lack of folic acid supplement use seem to be associated with higher phthalate concentrations in pregnant women. The major limitation was the availability of only one urine sample per participant. However, since phthalates are reported to be quite stable over time, results concerning determinants of phthalate concentrations are expected to be robust.

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“…Several studies examining individuals living in the US and other countries detected measureable amounts of these BPA-substitutes in urinary samples, but mixed results have been reported in maternal sera, and umbilical cord sera (Table 1) [41; 42; 43; 44; 45; 46; 47; 48; 49; 50; 51]. These other bisphenols induce a range of gene expression and morphological changes in in vitro cultures of human explants and cells lines, such as testis, red blood cells, blood mononuclear cells, preadipocytes, cancerous adrenal cortex cells, and osteosarcoma cells [52; 53; 54; 55; 56; 57; 58; 59; 60].…”

Section: Introductionmentioning

confidence: 99%

Neuroendocrine disruption in animal models due to exposure to bisphenol A analogues

Rosenfeld

2017

Frontiers in Neuroendocrinology

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Animal and human studies provide evidence that exposure to the endocrine disrupting chemical (EDC), bisphenol A (BPA), can lead to neurobehavioral disorders. Consequently, there is an impetus to identify safer alternatives to BPA. Three bisphenol compounds proposed as potential safer alternatives to BPA are bisphenol S (BPS), bisphenol F (BPF), and bisphenol AF (BPAF). However, it is not clear whether these other compounds are safer in terms of inducing less endocrine disrupting effects in animals and humans who are now increasingly coming into contact with these BPA-substitutes. In the past few years, several animal studies have shown exposure to these other bisphenols induce similar neurobehavioral disruption as BPA. We will explore in this review article the current studies suggesting these other bisphenols result in neuroendocrine disruptions that may be estrogen receptor-dependent. Current work may aide in designing future studies to test further whether these BPA-substitutes can act as neuroendocrine disruptors.

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Urinary biomarkers of exposure to 57 xenobiotics and its association with oxidative stress in a population in Jeddah, Saudi Arabia

Cited by 227 publications

References 44 publications

Urinary Concentrations of Parabens and Other Antimicrobial Chemicals and Their Association with Couples’ Fecundity

Urinary Concentrations of Parabens and Other Antimicrobial Chemicals and Their Association with Couples’ Fecundity

Bisphenol and phthalate concentrations and its determinants among pregnant women in a population-based cohort in the Netherlands, 2004–5

Neuroendocrine disruption in animal models due to exposure to bisphenol A analogues

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